Molecular Progression of Myeloproliferative and Myelodysplastic/Myeloproliferative Neoplasms: A Study on Sequential Bone Marrow Biopsies.
genetic testing
mutation analysis
myelodysplastic/myeloproliferative neoplasm
myeloproliferative neoplasm
risk stratification
secondary acute myeloid leukemia
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
09 Nov 2021
09 Nov 2021
Historique:
received:
07
09
2021
revised:
26
10
2021
accepted:
03
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Myeloproliferative neoplasms (MPN) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) both harbor the potential to undergo myelodysplastic progression or acceleration and can transform into blast-phase MPN or MDS/MPN, a form of secondary acute myeloid leukemia (AML). Although the initiating transforming events are yet to be determined, current concepts suggest a stepwise acquisition of (additional) somatic mutations-apart from the initial driver mutations-that trigger disease evolution. In this study we molecularly analyzed paired bone marrow samples of MPN and MDS/MPN patients with known progression and compared them to a control cohort of patients with stable disease course. Cases with progression displayed from the very beginning a higher number of mutations compared to stable ones, of which mutations in five (
Identifiants
pubmed: 34830756
pii: cancers13225605
doi: 10.3390/cancers13225605
pmc: PMC8615857
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swiss Life Jubiläumsstiftung
ID : n.a.
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