Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression.
DNA integrity
cancer stem cell
cell cycle
microenvironment
microinvasion
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Nov 2021
13 Nov 2021
Historique:
received:
23
09
2021
revised:
03
11
2021
accepted:
04
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Cyclin E1 (CCNE1) is a regulatory subunit of Cyclin-dependent kinase 2 (CDK2) and is thought to control the transition of quiescent cells into cell cycle progression. Recently, we identified CCNE1 and CDK2 as key factors for the initiation of hepatocellular carcinoma (HCC). In the present study, we dissected the contributions of CCNE1 and CDK2 for HCC progression in mice and patients. Therefore, we generated genetically modified mice allowing inducible deletion of
Identifiants
pubmed: 34830835
pii: cancers13225680
doi: 10.3390/cancers13225680
pmc: PMC8616292
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Grant LI1045/4-2
Organisme : Deutsche Forschungsgemeinschaft
ID : 331065168
Organisme : Faculty of Medicine at the RWTH Aachen University
ID : 118/19
Organisme : Faculty of Medicine at the RWTH Aachen University
ID : O3-2
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