Blood Cytokine Analysis Suggests That SARS-CoV-2 Infection Results in a Sustained Tumour Promoting Environment in Cancer Patients.
COVID-19
Th1
Th17
Th2
anti-inflammatory
haematological cancers
immune response
pro-inflammatory
solid cancers
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Nov 2021
15 Nov 2021
Historique:
received:
25
10
2021
revised:
08
11
2021
accepted:
10
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Cytokines, chemokines, and (angiogenic) growth factors (CCGs) have been shown to play an intricate role in the progression of both solid and haematological malignancies. Recent studies have shown that SARS-CoV-2 infection leads to a worse outcome in cancer patients, especially in haematological malignancy patients. Here, we investigated how SARS-CoV-2 infection impacts the already altered CCG levels in solid or haematological malignancies, specifically, whether there is a protective effect or rather a potentially higher risk for major COVID-19 complications in cancer patients due to elevated CCGs linked to cancer progression. Serially analysing immune responses with 55 CCGs in cancer patients under active treatment with or without SARS-CoV-2 infection, we first showed that cancer patients without SARS-CoV-2 infection (
Identifiants
pubmed: 34830872
pii: cancers13225718
doi: 10.3390/cancers13225718
pmc: PMC8616215
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Kom Op Tegen Kanker
ID : 000100470
Organisme : UZA Foundation grant
ID : 2020
Organisme : University of Antwerp
ID : 42839
Organisme : University of Antwerp
ID : s30729
Organisme : Innovative Medicines Initiative
ID : 115523 and 115737
Organisme : Horizon 2020
ID : Orchestra
Organisme : Research Foundation - Flanders
ID : FWO-SB151525 and FWO-1S93418N
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