Interventional Radiology Image-Guided Locoregional Therapies (LRTs) and Immunotherapy for the Treatment of HCC.
HCC
TACE
ablation
hepatocellular carcinoma
immunotherapy
interventional radiology
locoregional therapy
microwave ablation
radiofrequency
tumor immunology
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 Nov 2021
18 Nov 2021
Historique:
received:
08
10
2021
revised:
16
11
2021
accepted:
16
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Image-guided locoregional therapies (LRTs) are a crucial asset in the treatment of hepatocellular carcinoma (HCC), which has proven to be characterized by an impaired antitumor immune status. LRTs not only directly destroy tumor cells but also have an immunomodulating role, altering the tumor microenvironment with potential systemic effects. Nevertheless, the immune activation against HCC induced by LRTs is not strong enough on its own to generate a systemic significant antitumor response, and it is incapable of preventing tumor recurrence. Currently, there is great interest in the possibility of combining LRTs with immunotherapy for HCC, as this combination may result in a mutually beneficial and synergistic relationship. On the one hand, immunotherapy could amplify and prolong the antitumoral immune response of LRTs, reducing recurrence cases and improving outcome. On the other hand, LTRs counteract the typical immunosuppressive HCC microenvironment and status and could therefore enhance the efficacy of immunotherapy. Here, after reviewing the current therapeutic options for HCC, we focus on LRTs, describing for each of them the technique and data on its effect on the immune system. Then, we describe the current status of immunotherapy and finally report the recently published and ongoing clinical studies testing this combination.
Identifiants
pubmed: 34830949
pii: cancers13225797
doi: 10.3390/cancers13225797
pmc: PMC8616392
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Hepatol. 2013 Jan;58(1):58-64
pubmed: 22925812
Future Oncol. 2019 May;15(15):1791-1804
pubmed: 31044615
Ann Transl Med. 2016 Mar;4(6):118
pubmed: 27127771
Br J Cancer. 2005 Aug 22;93(4):435-40
pubmed: 16091763
Future Oncol. 2018 Dec;14(28):2957-2967
pubmed: 29712486
Radiology. 2017 Sep;284(3):877-886
pubmed: 28453431
J Vasc Interv Radiol. 2014 Jul;25(7):997-1011; quiz 1011
pubmed: 24656178
JAMA Oncol. 2017 Dec 1;3(12):1683-1691
pubmed: 28983565
Ultrasound Med Biol. 2004 Sep;30(9):1217-22
pubmed: 15550325
Cell Death Differ. 2006 May;13(5):785-97
pubmed: 16528384
Curr Opin Immunol. 2016 Apr;39:23-9
pubmed: 26724433
Gastroenterol Res Pract. 2016;2016:9251375
pubmed: 27051417
Int J Hyperthermia. 2017 Jun;33(4):435-439
pubmed: 28100078
J Acoust Soc Am. 2011 Oct;130(4):1888-98
pubmed: 21973343
J Vasc Interv Radiol. 2015 May;26(5):694-702
pubmed: 25812712
Int J Cancer. 2014 Jan 15;134(2):342-51
pubmed: 23825037
Immunol Rev. 2011 May;241(1):77-88
pubmed: 21488891
Acta Radiol. 2013 Oct;54(8):876-81
pubmed: 23761559
Liver Int. 2020 Oct;40(10):2544-2552
pubmed: 32563213
Biosci Trends. 2015 Oct;9(5):289-98
pubmed: 26559021
Am J Surg Pathol. 2012 Jul;36(7):980-6
pubmed: 22446942
Oncoimmunology. 2019 May 25;8(8):1615818
pubmed: 31413924
J Vasc Interv Radiol. 2020 Nov;31(11):1729-1738.e1
pubmed: 33012649
Anticancer Res. 2015 May;35(5):2961-7
pubmed: 25964582
Minim Invasive Ther Allied Technol. 2017 Dec;26(6):331-337
pubmed: 28417678
Curr Opin Biotechnol. 2020 Oct;65:60-64
pubmed: 32088576
Clin Gastroenterol Hepatol. 2007 Aug;5(8):938-45, 945.e1-4
pubmed: 17509946
Radiology. 2018 Sep;288(3):730-738
pubmed: 29737948
Ann Oncol. 2018 Oct 1;29(Suppl 4):iv238-iv255
pubmed: 30285213
Semin Intervent Radiol. 2014 Jun;31(2):149-56
pubmed: 25049444
Lancet. 2017 Jun 24;389(10088):2492-2502
pubmed: 28434648
Ultrasound Med Biol. 2016 Aug;42(8):1890-902
pubmed: 27140521
Radiol Med. 2007 Apr;112(3):377-93
pubmed: 17447018
Radiology. 2016 Aug;280(2):413-24
pubmed: 27429143
Cancer Lett. 2016 Jan 1;370(1):78-84
pubmed: 26472630
Cancer Res. 2003 Oct 1;63(19):6496-500
pubmed: 14559842
Lancet Oncol. 2018 Jul;19(7):940-952
pubmed: 29875066
Radiology. 2009 Apr;251(1):58-66
pubmed: 19251937
Int J Cancer. 2011 Jun 1;128(11):2653-62
pubmed: 20715115
Cardiovasc Intervent Radiol. 2017 Aug;40(8):1185-1195
pubmed: 28283704
Int Immunol. 2000 Nov;12(11):1539-46
pubmed: 11058573
J Hepatol. 2017 Mar;66(3):545-551
pubmed: 27816492
World J Gastroenterol. 2020 Jun 28;26(24):3421-3431
pubmed: 32655266
Hepatol Int. 2020 Mar;14(2):249-258
pubmed: 32072464
Immunity. 2014 Nov 20;41(5):843-52
pubmed: 25517616
Curr Probl Diagn Radiol. 2009 May-Jun;38(3):135-43
pubmed: 19298912
Lancet. 2018 Mar 31;391(10127):1301-1314
pubmed: 29307467
Asian Pac J Cancer Prev. 2014;15(6):2491-4
pubmed: 24761852
Hepatobiliary Pancreat Dis Int. 2021 Jun;20(3):240-250
pubmed: 33454220
Oncology. 2017;92 Suppl 1:40-49
pubmed: 27764823
Tumour Biol. 2012 Dec;33(6):2401-9
pubmed: 22965881
Surgery. 2012 Feb;151(2):213-22
pubmed: 21975289
Cytokine. 2013 Nov;64(2):516-22
pubmed: 24035756
PLoS One. 2015 Jul 08;10(7):e0128910
pubmed: 26154425
J Gastroenterol. 2010 Apr;45(4):451-8
pubmed: 19936602
J Cell Mol Med. 2017 Sep;21(9):1989-1999
pubmed: 28429395
Cryobiology. 2003 Jun;46(3):238-45
pubmed: 12818213
J Clin Oncol. 2005 Dec 1;23(34):8739-47
pubmed: 16314634
J Vasc Interv Radiol. 2015 Jul;26(7):1067-1075.e3
pubmed: 25952641
Cancer Res. 1996 Dec 1;56(23):5522-8
pubmed: 8968110
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Dig Dis Sci. 2013 Jun;58(6):1644-52
pubmed: 23361571
World J Gastroenterol. 2013 Jun 14;19(22):3473-80
pubmed: 23801841
Surgery. 2006 Jan;139(1):73-81
pubmed: 16364720
J Gastroenterol Hepatol. 2015 Mar;30(3):559-65
pubmed: 25251043
Oncoimmunology. 2012 Jan 1;1(1):48-55
pubmed: 22720211
Br J Cancer. 2006 Oct 9;95(7):896-905
pubmed: 16953240
Tech Vasc Interv Radiol. 2010 Jun;13(2):89-99
pubmed: 20540918
Int J Hyperthermia. 2003 Jan-Feb;19(1):89-101
pubmed: 12519714
Gastroenterology. 2010 May;138(5):1931-42
pubmed: 20060829
Eur J Cancer. 2018 Dec;105:1-9
pubmed: 30384012
J Surg Oncol. 2010 Oct 1;102(5):482-9
pubmed: 20872952
Hong Kong Med J. 2016 Aug;22(4):382-92
pubmed: 27380753
J Clin Oncol. 2020 Jan 20;38(3):193-202
pubmed: 31790344
Lasers Surg Med. 2004;35(4):284-92
pubmed: 15493028
J Hepatol. 2013 Nov;59(5):1007-13
pubmed: 23796475
Cancer Biomark. 2019;24(1):85-90
pubmed: 30347603
Oncotarget. 2017 May 11;8(47):81967-81977
pubmed: 29137237
Med Oncol. 2016 Dec;33(12):140
pubmed: 27837451
Annu Rev Immunol. 2013;31:51-72
pubmed: 23157435
Cell Stress Chaperones. 2011 Sep;16(5):495-504
pubmed: 21442384
Gut. 2019 Feb;68(2):335-346
pubmed: 29440463
World J Gastroenterol. 2014 Jun 28;20(24):7971-8
pubmed: 24976734
Hepatol Int. 2013 Jul;7(3):883-92
pubmed: 26201926
J Hepatol. 2019 May;70(5):999-1007
pubmed: 30738077
J Vasc Interv Radiol. 2014 Jan;25(1):112-8
pubmed: 24262034
Nucl Med Mol Imaging. 2019 Dec;53(6):367-373
pubmed: 31867071
Eur J Radiol. 2008 Aug;67(2):336-347
pubmed: 17765421
Nat Commun. 2019 Nov 28;10(1):5421
pubmed: 31780645
Oncology (Williston Park). 2005 Oct;19(11 Suppl 4):27-32
pubmed: 16366376
Curr Oncol. 2020 Nov;27(Suppl 3):S144-S151
pubmed: 33343208
Genet Mol Res. 2015 Aug 21;14(3):10015-25
pubmed: 26345938
Med Oncol. 2020 Apr 2;37(5):39
pubmed: 32239295
Hum Immunol. 2009 Jul;70(7):477-86
pubmed: 19332094
Minim Invasive Ther Allied Technol. 2017 Aug;26(4):207-211
pubmed: 28635405
Radiology. 2015 Jun;275(3):908-19
pubmed: 25688888
Front Oncol. 2020 Oct 29;10:519164
pubmed: 33194582
Biotechnol Biotechnol Equip. 2015 Jan 2;29(1):119-123
pubmed: 26019624
JAMA Oncol. 2017 Feb 01;3(2):235-243
pubmed: 27657674
Eur J Cancer. 2014 Mar;50(5):912-9
pubmed: 24411080
Br J Anaesth. 2014 Dec;113(6):985-92
pubmed: 25173767
Liver Int. 2015 May;35(5):1590-6
pubmed: 24836705
Radiology. 2005 Oct;237(1):366-70
pubmed: 16126920
Tech Vasc Interv Radiol. 2013 Dec;16(4):262-8
pubmed: 24238381
Int J Mol Sci. 2019 Dec 25;21(1):
pubmed: 31881671
Ann Surg Oncol. 2003 Apr;10(3):275-83
pubmed: 12679313
Radiology. 2015 Aug;276(2):426-32
pubmed: 26203709
Hum Immunol. 2010 Dec;71(12):1180-6
pubmed: 20870003
Med Oncol. 2012 Sep;29(3):1817-26
pubmed: 21678026
Int J Radiat Biol. 2019 Jul;95(7):936-939
pubmed: 31120369
N Engl J Med. 2020 May 14;382(20):1894-1905
pubmed: 32402160
Prostate. 2004 Feb 1;58(2):109-20
pubmed: 14716736
Radiographics. 2005 Oct;25 Suppl 1:S69-83
pubmed: 16227498
P T. 2017 Jul;42(7):452-463
pubmed: 28674473
J Vasc Interv Radiol. 2020 Mar;31(3):482-491.e4
pubmed: 31956003
Hepatology. 2011 Apr;53(4):1206-16
pubmed: 21480325
J Immunother Cancer. 2017 Oct 17;5(1):78
pubmed: 29037259
J Immunother Cancer. 2020 Jan;8(1):
pubmed: 31940590
Radiology. 2016 Apr;279(1):103-17
pubmed: 26418615
Gastroenterology. 2007 Jun;132(7):2328-39
pubmed: 17570208
World J Gastroenterol. 2004 Apr 15;10(8):1137-40
pubmed: 15069713
Nat Med. 2007 Sep;13(9):1050-9
pubmed: 17704786
J Clin Med. 2019 Mar 19;8(3):
pubmed: 30893948
J Clin Oncol. 2020 Sep 10;38(26):2960-2970
pubmed: 32716739
Ann Surg Oncol. 2010 Apr;17(4):1187-93
pubmed: 20033323
Cell Res. 2019 Oct;29(10):846-861
pubmed: 31481761
Cancer Immunol Immunother. 2018 May;67(5):843-853
pubmed: 29500633
J Surg Res. 2005 Aug;127(2):208-23
pubmed: 16083756
J Clin Oncol. 2009 Jun 1;27(16):2615-21
pubmed: 19332729
Am Surg. 2011 Nov;77(11):1496-501
pubmed: 22196664
Am Surg. 2019 Jan 1;85(1):103-110
pubmed: 30760354
Ultrasound Med Biol. 2008 Jan;34(1):81-7
pubmed: 17854983
Radiology. 2005 Mar;234(3):961-7
pubmed: 15665226
Clin Cancer Res. 2004 Jul 1;10(13):4332-41
pubmed: 15240519
J Vasc Interv Radiol. 2019 Jun;30(6):845-853.e6
pubmed: 31126596
Phys Med Biol. 1998 Dec;43(12):3535-47
pubmed: 9869030
J Surg Oncol. 2010 Jun 1;101(7):551-6
pubmed: 20461760
Cancer Res. 2012 Jan 15;72(2):430-9
pubmed: 22108823
J Vasc Interv Radiol. 2013 Aug;24(8):1105-12
pubmed: 23582441
Int J Hyperthermia. 2019;36(1):95-103
pubmed: 30428719
Nat Rev Cancer. 2014 Mar;14(3):199-208
pubmed: 24561446
J Transl Med. 2017 Jan 31;15(1):23
pubmed: 28137271
Radiology. 2001 Dec;221(3):712-20
pubmed: 11719667
Cancer Control. 2017 Jul-Sep;24(3):1073274817729243
pubmed: 28975834
J Hepatocell Carcinoma. 2017 Mar 13;4:49-58
pubmed: 28331845
Int J Hyperthermia. 2005 Jun;21(4):319-32
pubmed: 16019858
Br J Radiol. 2016 Jun;89(1062):20150943
pubmed: 26943239
Cancer Biol Ther. 2011 Mar 1;11(5):450-6
pubmed: 21258206
Zhonghua Yi Xue Za Zhi. 2002 Mar 25;82(6):393-7
pubmed: 11953205
Cancer Cell. 2006 Aug;10(2):99-111
pubmed: 16904609
PLoS One. 2012;7(5):e37266
pubmed: 22615958
Cytokine. 2017 May;93:44-50
pubmed: 28506570
NMR Biomed. 2016 Jun;29(6):721-31
pubmed: 27061290
Cancer Res. 2014 Oct 1;74(19):5458-68
pubmed: 25274032
J Hepatol. 2005 Nov;43(5):817-22
pubmed: 16087270
Cancer Lett. 2018 May 1;421:73-81
pubmed: 29458142
Int J Hyperthermia. 2003 Mar-Apr;19(2):119-33
pubmed: 12623635
Oncologist. 2019 Oct;24(10):e990-e1005
pubmed: 31217342
World J Hepatol. 2015 Aug 8;7(16):2009-19
pubmed: 26261690
J Hepatol. 2015 Jun;62(6):1420-9
pubmed: 25733155
Int J Hyperthermia. 2020;37(1):1313-1321
pubmed: 33243024
Rofo. 2016 Aug;188(8):735-45
pubmed: 27074423
Int J Hyperthermia. 2005 May;21(3):247-57
pubmed: 16019851
Am J Surg. 2010 Oct;200(4):500-6
pubmed: 20887844
PLoS One. 2011;6(9):e23621
pubmed: 21912640
J Surg Oncol. 2013 Apr;107(5):544-9
pubmed: 23090720
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):120-130
pubmed: 27084634
Radiology. 2013 Feb;266(2):462-70
pubmed: 23169795
Technol Cancer Res Treat. 2004 Apr;3(2):95-101
pubmed: 15059015
Sci Rep. 2017 Sep 4;7(1):10376
pubmed: 28871164
Hepatology. 2013 Apr;57(4):1448-57
pubmed: 23174905
HPB (Oxford). 2010 Jun;12(5):348-51
pubmed: 20590911
Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1128-35
pubmed: 21093169
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
Radiology. 2004 Apr;231(1):143-9
pubmed: 14990816
J Clin Gastroenterol. 2012 Oct;46(9):796-801
pubmed: 22955262
Science. 2015 Apr 3;348(6230):62-8
pubmed: 25838374
Cell Biochem Biophys. 2015 Dec;73(3):787-92
pubmed: 27259326
Oncotarget. 2017 Dec 11;9(1):1130-1142
pubmed: 29416682
World J Hepatol. 2014 Oct 27;6(10):704-15
pubmed: 25349642
J Exp Med. 2006 May 15;203(5):1259-71
pubmed: 16636135
J Cancer Res Clin Oncol. 2010 Nov;136(11):1745-54
pubmed: 20221638
Ann Surg. 2009 May;249(5):814-23
pubmed: 19387320
Apoptosis. 2016 Jan;21(1):110-9
pubmed: 26496775
Liver Int. 2012 Apr;32(4):644-55
pubmed: 22118340
Lab Invest. 2007 Jun;87(6):582-90
pubmed: 17372588
Cryobiology. 2009 Feb;58(1):1-11
pubmed: 19007768
Clin Dev Immunol. 2011;2011:160250
pubmed: 22242035
Oncotarget. 2014 Jan 30;5(2):403-16
pubmed: 24480782