Amyloid-Beta Peptides and Activated Astroglia Impairs Proliferation of Nerve Growth Factor Releasing Cells In Vitro: Implication for Encapsulated Cell Biodelivery-Mediated AD Therapy.
Alzheimer Disease
/ cerebrospinal fluid
Amyloid beta-Peptides
/ metabolism
Astrocytes
/ metabolism
Cell Line
Cell Proliferation
Cells, Immobilized
/ cytology
Cognitive Dysfunction
/ cerebrospinal fluid
Culture Media, Conditioned
/ pharmacology
Humans
Lewy Body Disease
/ cerebrospinal fluid
Nerve Growth Factor
/ metabolism
Peptides
/ metabolism
Stress, Physiological
Alzheimer’s disease (AD)
amyloid beta (Aβ)
astrocytes
drug delivery strategy optimization
encapsulated cell biodelivery (ECB)
inflammation
nerve growth factor (NGF)
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
21 10 2021
21 10 2021
Historique:
received:
17
08
2021
revised:
29
09
2021
accepted:
14
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) treatment is constrained due to the inability of peripherally administered therapeutic molecules to cross the blood-brain barrier. Encapsulated cell biodelivery (ECB) devices, a tissue-targeted approach for local drug release, was previously optimized for human mature nerve growth factor (hmNGF) delivery in AD patients but was found to have reduced hmNGF release over time. To understand the reason behind reduced ECB efficacy, we exposed hmNGF-releasing cells (NGC0211) in vitro to human cerebrospinal fluid (CSF) obtained from Subjective Cognitive Impairment (SCI), Lewy Body Dementia (LBD), and AD patients. Subsequently, we exposed NGC0211 cells directly to AD-related factors like amyloid-β peptides (Aβ
Identifiants
pubmed: 34831056
pii: cells10112834
doi: 10.3390/cells10112834
pmc: PMC8616486
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Culture Media, Conditioned
0
Peptides
0
Nerve Growth Factor
9061-61-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swedish research council
ID : 2016-02317
Organisme : Hjärnfonden
ID : 201801
Organisme : Demensfonden
ID : 20182020
Organisme : Lindhés stiftelse
ID : 20200310
Organisme : Gun and Bertil Stohne's Foundation
ID : 20200830
Organisme : Gamla Tjänarinnor stiftelse
ID : 2020201905
Organisme : Åhlen stiftelse
ID : 02311
Organisme : Alzheimerfonden
ID : 20180925
Organisme : Tore Nilsson stiftelse,
ID : 20210310
Organisme : KI Geriatric research
ID : 20200421
Organisme : KI fund
ID : 202104
Organisme : ALF Foundation for medicine
ID : 20182020
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