Inhibitors of the
Hsp90 inhibitors
Plasmodium falciparum
heat shock protein 90
malaria
molecular chaperone
parasite Hsp90
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
22 10 2021
22 10 2021
Historique:
received:
23
09
2021
revised:
14
10
2021
accepted:
15
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
5
1
2022
Statut:
epublish
Résumé
Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public health threat. The development of antimalarial drug resistance is reversing the gains made in attempts to control the disease. The parasite leads a complex life cycle that has adapted to outwit almost all known antimalarial drugs to date, including the first line of treatment, artesunate. There is a high unmet need to develop new strategies and identify novel therapeutics to reverse antimalarial drug resistance development. Among the strategies, here we focus and discuss the merits of the development of antimalarials targeting the Heat shock protein 90 (Hsp90) due to the central role it plays in protein quality control.
Identifiants
pubmed: 34831072
pii: cells10112849
doi: 10.3390/cells10112849
pmc: PMC8616389
pii:
doi:
Substances chimiques
Antimalarials
0
HSP90 Heat-Shock Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation
ID : 129401
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