Multiple Myeloma Cell-Derived Exosomes: Implications on Tumorigenesis, Diagnosis, Prognosis and Therapeutic Strategies.
angiogenesis
chemoresistance
exosome
extracellular vesicles
immune response
miRNA
microenvironment
multiple myeloma
osteoclast
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 10 2021
24 10 2021
Historique:
received:
05
10
2021
revised:
20
10
2021
accepted:
21
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Multiple myeloma (MM) is a hematological disease that is still not curable. The bone marrow milieu, with cellular and non-cellular elements, participate in the creation of a pro-tumoral environment enhancing growth and survival of MM plasma cells. Exosomes are vesicles oscillating in dimension between 50 nm and 100 nm in size that can be released by various cells and contribute to the pathogenesis and progression of MM. Exosomes enclose proteins, cytokines, lipids, microRNAs, long noncoding RNAs, and circular RNAs able to regulate interactions between MM plasma cells and adjacent cells. Through exosomes, mesenchymal stem cells confer chemoresistance to MM cells, while myeloma cells promote angiogenesis, influence immune response, cause bone lesions, and have an impact on the outcome of MM patients. In this review, we analyze the role played by exosomes in the progression of monoclonal gammopathies and the effects on the proliferation of neoplastic plasma cells, and discuss the possible employment of exosomes as potential targets for the treatment of MM patients.
Identifiants
pubmed: 34831088
pii: cells10112865
doi: 10.3390/cells10112865
pmc: PMC8616233
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Neoplasia. 2016 Jan;18(1):25-32
pubmed: 26806349
Blood. 2014 Dec 11;124(25):3748-57
pubmed: 25320245
PLoS One. 2010 Jul 22;5(7):e11469
pubmed: 20661468
Endocr Relat Cancer. 2005 Jun;12(2):471-82
pubmed: 15947117
J Biotechnol. 2013 May 20;165(2):77-84
pubmed: 23562828
Bone. 2003 Jul;33(1):28-37
pubmed: 12919697
Thromb Res. 2016 Apr;140 Suppl 1:S193
pubmed: 27161734
J Hematol Oncol. 2019 Jan 8;12(1):2
pubmed: 30621731
Stem Cells Int. 2017;2017:9012152
pubmed: 29333170
Medicine (Baltimore). 2021 Jan 29;100(4):e23447
pubmed: 33530159
Oncogene. 2018 Oct;37(41):5508-5519
pubmed: 29895968
Cancers (Basel). 2021 Apr 01;13(7):
pubmed: 33915822
Semin Thromb Hemost. 2021 Jul;47(5):569-580
pubmed: 34058766
Front Immunol. 2017 Mar 20;8:305
pubmed: 28373875
Cancer Biol Med. 2021 Aug 17;:
pubmed: 34403220
Adv Cancer Res. 2013;117:37-58
pubmed: 23290776
J Extracell Vesicles. 2014 Aug 04;3:
pubmed: 25143819
Oncogenesis. 2016 Feb 29;5:e202
pubmed: 26926788
Mol Med. 2016 Dec;22:694-704
pubmed: 27761584
J Control Release. 2016 Apr 28;228:179-190
pubmed: 26941033
Cells. 2019 Dec 12;8(12):
pubmed: 31842517
Biomaterials. 2011 Nov;32(32):8190-204
pubmed: 21835463
J Clin Invest. 2010 Feb;120(2):457-71
pubmed: 20093776
Cytotherapy. 2009;11(5):503-15
pubmed: 19728189
Clin Exp Metastasis. 2011 Oct;28(7):649-59
pubmed: 21688034
Leuk Lymphoma. 2018 Jan;59(1):14-28
pubmed: 28573897
J Transl Med. 2020 Aug 3;18(1):298
pubmed: 32746845
Oncotarget. 2015 May 30;6(15):13772-89
pubmed: 25944696
Oncol Rep. 2020 Jun;43(6):1729-1736
pubmed: 32236596
Blood. 2016 Dec 8;128(23):2655-2665
pubmed: 27742710
ACS Omega. 2020 Nov 18;5(47):30436-30443
pubmed: 33283091
J Proteomics. 2016 Mar 16;136:89-98
pubmed: 26775013
Am J Pathol. 2016 Aug;186(8):2171-2182
pubmed: 27301357
Cancer Cell Int. 2021 Jun 13;21(1):311
pubmed: 34120606
Cancer Cell Int. 2020 Aug 08;20:383
pubmed: 32782441
Blood Rev. 2019 Nov;38:100595
pubmed: 31445775
Arch Med Sci. 2021 Jan 11;18(3):696-703
pubmed: 35591819
Eur J Haematol. 2013 Jun;90(6):441-68
pubmed: 23506222
Eur J Cancer. 2006 Jul;42(11):1581-90
pubmed: 16797965
Pathol Res Pract. 2020 Oct;216(10):153114
pubmed: 32853951
Eur J Cancer Care (Engl). 2020 Mar;29(2):e13208
pubmed: 31899849
Nat Rev Immunol. 2009 Mar;9(3):162-74
pubmed: 19197294
Leukemia. 2013 Aug;27(8):1729-37
pubmed: 23478664
Oncoimmunology. 2018 May 7;7(8):e1458809
pubmed: 30221054
Onco Targets Ther. 2021 Jan 15;14:455-467
pubmed: 33488100
Oncoimmunology. 2017 Jan 13;6(3):e1279372
pubmed: 28405503
Crit Rev Oncol Hematol. 2015 Nov;96(2):339-54
pubmed: 26123319
Cancer Lett. 2016 Jul 10;377(1):17-24
pubmed: 27102001
Blood Adv. 2017 Dec 13;1(27):2656-2666
pubmed: 29296919
Cell Biochem Biophys. 2020 Mar;78(1):77-88
pubmed: 31811601
Leukemia. 2020 Apr;34(4):985-1005
pubmed: 32055000
Leukemia. 2018 Mar;32(3):765-773
pubmed: 28852198
Hematol Oncol. 2018 Dec;36(5):786-791
pubmed: 30144133
Int J Mol Sci. 2016 Aug 26;17(9):
pubmed: 27571072
Cancer Res. 2007 Aug 1;67(15):7458-66
pubmed: 17671216
Clin Cancer Res. 2019 Mar 15;25(6):1923-1935
pubmed: 30610101
J Extracell Vesicles. 2016 Mar 07;5:29877
pubmed: 26955882
Nat Commun. 2015 Dec 03;6:8983
pubmed: 26632274
Cancer Biother Radiopharm. 2010 Feb;25(1):21-8
pubmed: 20187793
Yale J Biol Med. 2017 Mar 29;90(1):63-71
pubmed: 28356894
Spectrochim Acta A Mol Biomol Spectrosc. 2016 Apr 15;159:21-9
pubmed: 26827173
Leukemia. 2011 Oct;25(10):1533-42
pubmed: 21637285
J Cell Physiol. 2008 Nov;217(2):409-22
pubmed: 18543257
Cancers (Basel). 2019 Nov 06;11(11):
pubmed: 31698726
Blood. 2014 Jul 24;124(4):555-66
pubmed: 24928860
J Biol Chem. 2016 Jan 22;291(4):1652-1663
pubmed: 26601950
Biomed Res Int. 2019 Dec 14;2019:1575468
pubmed: 31915680
Cancer Cell. 2014 Nov 10;26(5):707-21
pubmed: 25446899
Eur J Haematol. 2011 Feb;86(2):93-110
pubmed: 21114539
Cancer Lett. 2009 Oct 8;283(2):168-75
pubmed: 19401262
J Immunol. 2007 Jun 1;178(11):6867-75
pubmed: 17513735
Oncotarget. 2016 May 24;7(21):30876-91
pubmed: 27129167
J Dent Res. 2016 Jun;95(6):673-9
pubmed: 26908631
Spectrochim Acta A Mol Biomol Spectrosc. 2017 Dec 5;187:15-22
pubmed: 28645097
Cureus. 2018 Dec 18;10(12):e3749
pubmed: 30820370
Cancers (Basel). 2020 Feb 14;12(2):
pubmed: 32075123
ACS Nano. 2013 Sep 24;7(9):7698-710
pubmed: 24004438
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Mol Ther. 2016 Aug;24(7):1290-301
pubmed: 27203438
Ann Hematol. 2021 Jun;100(6):1553-1567
pubmed: 33866396
Blood Cancer J. 2019 Feb 26;9(3):26
pubmed: 30808934
Oncogene. 2018 Apr;37(16):2137-2149
pubmed: 29367765
J Biol Chem. 2007 Sep 14;282(37):26656-26665
pubmed: 17636266
Blood. 2005 Feb 1;105(3):1303-9
pubmed: 15471949
Leukemia. 2020 Jan;34(1):196-209
pubmed: 31142847
Mol Cancer. 2017 Oct 13;16(1):159
pubmed: 29029605
Diagnostics (Basel). 2020 Dec 09;10(12):
pubmed: 33316884
Oncotarget. 2017 Aug 27;8(43):73723-73732
pubmed: 29088739
Cell Signal. 2021 Feb;78:109872
pubmed: 33290841
Blood. 2017 Apr 27;129(17):2429-2436
pubmed: 28213378
Biochim Biophys Acta. 2012 Aug;1826(1):103-11
pubmed: 22503823
J Extracell Vesicles. 2017 Sep 26;6(1):1378056
pubmed: 29184623
J Clin Pathol. 2016 Feb;69(2):97-101
pubmed: 26598624
Blood Adv. 2020 May 26;4(10):2297-2307
pubmed: 32453840
Turk J Haematol. 2020 Aug 19;37(4):248-262
pubmed: 32812415
Oncol Rep. 2017 Feb;37(2):671-683
pubmed: 27922687
Oncotarget. 2015 Dec 22;6(41):43992-4004
pubmed: 26556857
Cancers (Basel). 2019 Nov 20;11(12):
pubmed: 31756922
Angiogenesis. 2017 Nov;20(4):443-462
pubmed: 28840415
Blood. 2009 Jan 15;113(3):517-25
pubmed: 18687985
Clin Lymphoma Myeloma Leuk. 2019 Jun;19(6):372-380
pubmed: 30930134
PLoS One. 2013 Sep 18;8(9):e75227
pubmed: 24058665
J Cell Biol. 2016 Apr 25;213(2):173-84
pubmed: 27114500
Hematol Oncol. 2019 Oct;37(4):409-417
pubmed: 31102419
J Cancer. 2021 Mar 14;12(10):2825-2834
pubmed: 33854583
Pharmacol Ther. 2018 Feb;182:176-192
pubmed: 28911826
Cell Discov. 2016 May 31;2:16015
pubmed: 27462462
J Pathol. 2016 Jun;239(2):162-73
pubmed: 26956697
J Immunol. 2015 Jul 15;195(2):736-48
pubmed: 26071561
Clin Cancer Res. 2016 Jul 15;22(14):3499-512
pubmed: 26944067
Front Oncol. 2020 Apr 15;10:438
pubmed: 32351883
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Dec;25(6):1713-1717
pubmed: 29262903
Leuk Lymphoma. 2012 Sep;53(9):1666-76
pubmed: 22423650
Sci Rep. 2021 May 26;11(1):10957
pubmed: 34040057
Theranostics. 2021 Jan 1;11(5):2364-2380
pubmed: 33500730
Sci Rep. 2016 Feb 04;6:20254
pubmed: 26842680
Cells. 2021 Feb 19;10(2):
pubmed: 33669515
Genome Med. 2019 Aug 26;11(1):55
pubmed: 31446897
J Cell Mol Med. 2010 Nov;14(11):2655-66
pubmed: 19627400
Leukemia. 2012 Apr;26(4):595-608
pubmed: 22193964
Front Oncol. 2019 Nov 19;9:1261
pubmed: 31803627
Int J Cancer. 2011 May 1;128(9):2038-49
pubmed: 20648559
Int J Oncol. 2012 Dec;41(6):1897-912
pubmed: 23026890
J Biol Chem. 2014 Aug 8;289(32):22258-67
pubmed: 24951588
Curr Osteoporos Rep. 2017 Oct;15(5):499-506
pubmed: 28889371
Blood Adv. 2017 May 16;1(13):812-823
pubmed: 29296725
Front Immunol. 2018 Nov 05;9:2551
pubmed: 30455698
J Investig Med. 2020 Jan;68(1):45-51
pubmed: 31784427
Stem Cell Res Ther. 2015 Jul 01;6:127
pubmed: 26129847
Cancer Immunol Res. 2018 Jul;6(7):860-869
pubmed: 29691234
Biosens Bioelectron. 2015 Dec 15;74:398-405
pubmed: 26164011
Crit Rev Oncol Hematol. 2019 Jul;139:125-127
pubmed: 30890387
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Sep 5;258:119813
pubmed: 33892305
Haematologica. 2018 Oct;103(10):e469-e472
pubmed: 29700168
Cytotherapy. 2019 Jan;21(1):96-106
pubmed: 30409700
J Control Release. 2014 Oct 28;192:262-70
pubmed: 25084218
Br J Haematol. 2014 Jun;165(6):801-13
pubmed: 24620752
Theranostics. 2017 Jan 26;7(3):789-804
pubmed: 28255367
Matrix Biol. 2018 Jan;65:104-118
pubmed: 28888912
Blood. 2001 Jul 15;98(2):428-35
pubmed: 11435313
Int J Cancer. 2009 Jun 1;124(11):2621-33
pubmed: 19235923
Biosens Bioelectron. 2016 Mar 15;77:518-24
pubmed: 26469728
Daru. 2020 Dec;28(2):647-659
pubmed: 32974883
Oncol Lett. 2020 Oct;20(4):31
pubmed: 32774504
Cancer Res. 2005 Jun 15;65(12):5238-47
pubmed: 15958569
Bone. 2015 Oct;79:37-42
pubmed: 26013558
Cells. 2021 Feb 20;10(2):
pubmed: 33672466
Front Oncol. 2020 Nov 05;10:608815
pubmed: 33251153
Blood Cancer J. 2018 Nov 8;8(11):105
pubmed: 30409995