Relevance of Neutrophil Neprilysin in Heart Failure.
CD10
biomarker
heart failure
neprilysin
neutrophils
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 10 2021
28 10 2021
Historique:
received:
21
09
2021
revised:
24
10
2021
accepted:
25
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
4
1
2022
Statut:
epublish
Résumé
Significant expression of neprilysin (NEP) is found on neutrophils, which present the transmembrane integer form of the enzyme. This study aimed to investigate the relationship of neutrophil transmembrane neprilysin (mNEP) with disease severity, adverse remodeling, and outcome in HFrEF. In total, 228 HFrEF, 30 HFpEF patients, and 43 controls were enrolled. Neutrophil mNEP was measured by flow-cytometry. NEP activity in plasma and blood cells was determined for a subset of HFrEF patients using mass-spectrometry. Heart failure (HF) was characterized by reduced neutrophil mNEP compared to controls (
Identifiants
pubmed: 34831146
pii: cells10112922
doi: 10.3390/cells10112922
pmc: PMC8616455
pii:
doi:
Substances chimiques
Neprilysin
EC 3.4.24.11
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CVC Translational Synergy Grant
ID : CVC Translational Synergy Grant 2020
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