Quantification of EGFR-HER2 Heterodimers in HER2-Overexpressing Breast Cancer Cells Using Liquid-Phase Electron Microscopy.

EGFR EGFR/HER2 heterodimers HER2 absolute quantification breast cancer cancer cell heterogeneity correlative light- and liquid-phase electron microscopy gastric cancer single molecule detection

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
19 11 2021
Historique:
received: 12 10 2021
revised: 10 11 2021
accepted: 15 11 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 15 12 2021
Statut: epublish

Résumé

Currently, breast cancer patients are classified uniquely according to the expression level of hormone receptors, and human epidermal growth factor receptor 2 (HER2). This coarse classification is insufficient to capture the phenotypic complexity and heterogeneity of the disease. A methodology was developed for absolute quantification of receptor surface density

Identifiants

pubmed: 34831465
pii: cells10113244
doi: 10.3390/cells10113244
pmc: PMC8623301
pii:
doi:

Substances chimiques

EGFR protein, human EC 2.7.10.1
ERBB2 protein, human EC 2.7.10.1
ErbB Receptors EC 2.7.10.1
Receptor, ErbB-2 EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1027-C7
Organisme : Else Kröner-Fresenius-Stiftung
ID : Investigation of the Influence of Breast Cancer Drugs on HER2 Dimerization at the Molecular Level in Individual Cells Aiming to Find Clues for Causes of Drug Resistance: HERe

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Auteurs

Diana B Peckys (DB)

Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital, Saarland University, 66421 Homburg, Germany.

Daniel Gaa (D)

INM-Leibniz Institute for New Materials, 66123 Saarbrücken, Germany.

Niels de Jonge (N)

INM-Leibniz Institute for New Materials, 66123 Saarbrücken, Germany.
Department of Physics, Saarland University, 66123 Saarbrücken, Germany.

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