Spatial and Temporal Trends of SARS-CoV-2 RNA from Wastewater Treatment Plants over 6 Weeks in Cape Town, South Africa.


Journal

International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455

Informations de publication

Date de publication:
17 11 2021
Historique:
received: 05 08 2021
revised: 13 10 2021
accepted: 20 10 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 15 12 2021
Statut: epublish

Résumé

Recent scientific trends have revealed that the collection and analysis of data on the occurrence and fate of SARS-CoV-2 in wastewater may serve as an early warning system for COVID-19. In South Africa, the first COVID-19 epicenter emerged in the Western Cape Province. The City of Cape Town, located in the Western Cape Province, has approximately 4 million inhabitants. This study reports on the monitoring of SARS-CoV-2 RNA in the wastewater of the City of Cape Town's wastewater treatment plants (WWTPs) during the peak of the epidemic. During this period, the highest overall median viral RNA signal was observed in week 1 (9200 RNA copies/mL) and declined to 127 copies/mL in week 6. The overall decrease in the amount of detected viral SARS-CoV-2 RNA over the 6-week study period was associated with a declining number of newly identified COVID-19 cases in the city. The SARS-CoV-2 early warning system has now been established to detect future waves of COVID-19.

Identifiants

pubmed: 34831841
pii: ijerph182212085
doi: 10.3390/ijerph182212085
pmc: PMC8618134
pii:
doi:

Substances chimiques

RNA, Viral 0
Waste Water 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Michael and Susan Dell Foundation
ID : 96829
Organisme : South African Medical Research Council
ID : 40118

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Auteurs

Renée Street (R)

Environment & Health Research Unit, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Angela Mathee (A)

Environment & Health Research Unit, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Environmental Health Department, Faculty of Health Sciences, University of Johannesburg, Johannesburg 2092, South Africa.

Noluxabiso Mangwana (N)

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Department of Microbiology, Stellenbosch University, Stellenbosch 7600, South Africa.

Stephanie Dias (S)

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Jyoti Rajan Sharma (JR)

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Pritika Ramharack (P)

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Johan Louw (J)

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.

Tarylee Reddy (T)

Biostatistics Unit, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Ludwig Brocker (L)

Department of Microbiology, Stellenbosch University, Stellenbosch 7600, South Africa.

Swastika Surujlal-Naicker (S)

Scientific Services, Water and Sanitation Department, City of Cape Town Metropolitan Municipality, Cape Town 8000, South Africa.

Natacha Berkowitz (N)

Community Services and Health, City Health, City of Cape Town, Hertzog Boulevard, Cape Town 8001, South Africa.

Mokaba Shirley Malema (MS)

Environment & Health Research Unit, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Sizwe Nkambule (S)

Environment & Health Research Unit, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Candice Webster (C)

Environment & Health Research Unit, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Nomfundo Mahlangeni (N)

Environment & Health Research Unit, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.

Huub Gelderblom (H)

COVID-19 Prevention Network (COVPN), Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Mongezi Mdhluli (M)

Office of the President, South African Medical Research Council, Tygerberg 7050, South Africa.

Glenda Gray (G)

Chief Research Operations Office, South African Medical Research Council, Tygerberg 7050, South Africa.

Christo Muller (C)

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.
Centre for Cardio-Metabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7600, South Africa.

Rabia Johnson (R)

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Centre for Cardio-Metabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7600, South Africa.
Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa.

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