A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines.
HIV infection
pathogenesis
sexually transmitted infections
syphilis
vaccine
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
21 Oct 2021
21 Oct 2021
Historique:
received:
30
08
2021
revised:
14
10
2021
accepted:
19
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
In 2021 the scientific community's efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum (TP) and is one of the oldest known diseases. Its incidence has increased in the last few years and syphilis still remains a contemporary plague that continues to afflict millions of people worldwide. Despite research improvements, syphilis pathogenesis is not completely clear; clinical presentation is very heterogeneous and the diagnosis can sometimes be difficult. Furthermore, few therapeutic options are available, and a vaccine has not been found yet. In this review, we describe the most recent evidence concerning the clinical manifestation, diagnosis, treatment and vaccine prospectives for this disease.
Identifiants
pubmed: 34832520
pii: pathogens10111364
doi: 10.3390/pathogens10111364
pmc: PMC8620723
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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