Risk Factors for Nodding Syndrome and Other Forms of Epilepsy in Northern Uganda: A Case-Control Study.

Uganda epilepsy nodding syndrome onchocerciasis risk factors

Journal

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317

Informations de publication

Date de publication:
09 Nov 2021
Historique:
received: 01 09 2021
revised: 04 11 2021
accepted: 05 11 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 28 11 2021
Statut: epublish

Résumé

Epidemiological studies suggest a link between onchocerciasis and various forms of epilepsy, including nodding syndrome (NS). The aetiopathology of onchocerciasis associated epilepsy remains unknown. This case-control study investigated potential risk factors that may lead to NS and other forms of non-nodding epilepsy (OFE) in northern Uganda. We consecutively recruited 154 persons with NS (aged between 8 and 20 years), and age-frequency matched them with 154 with OFE and 154 healthy community controls. Participants' socio-demography, medical, family, and migration histories were recorded. We tested participants for

Identifiants

pubmed: 34832607
pii: pathogens10111451
doi: 10.3390/pathogens10111451
pmc: PMC8621683
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Medical Research Council
ID : MR/M025489/1
Pays : United Kingdom

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Auteurs

Nolbert Gumisiriza (N)

Department of Mental Health, Kabale University School of Medicine, Kabale P.O. Box 317, Uganda.

Marina Kugler (M)

Global Health Institute, University of Antwerp, 2600 Antwerp, Belgium.

Nele Brusselaers (N)

Global Health Institute, University of Antwerp, 2600 Antwerp, Belgium.
Centre for Translational Microbiome Research, Karolinska Institute, 17177 Stockholm, Sweden.

Frank Mubiru (F)

Department of Statistical methods, School of Statistics and Planning, College of Business and Management Sciences, Makerere University, Kampala P.O. Box 7062, Uganda.

Ronald Anguzu (R)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
Division of Epidemiology, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Albert Ningwa (A)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
Centre of Tropical Neuroscience, Kitgum Site, Kampala P.O. Box 27520, Uganda.

Rodney Ogwang (R)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
Centre of Tropical Neuroscience, Kitgum Site, Kampala P.O. Box 27520, Uganda.
KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Coast, Kilifi P.O. Box 230-80108, Kenya.

Pamela Akun (P)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
Centre of Tropical Neuroscience, Kitgum Site, Kampala P.O. Box 27520, Uganda.

Amos Deogratius Mwaka (AD)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.

Catherine Abbo (C)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.

Rogers Sekibira (R)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.

An Hotterbeekx (A)

Global Health Institute, University of Antwerp, 2600 Antwerp, Belgium.

Robert Colebunders (R)

Global Health Institute, University of Antwerp, 2600 Antwerp, Belgium.

Kevin Marsh (K)

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford OX3 7LG, UK.

Richard Idro (R)

College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
Centre of Tropical Neuroscience, Kitgum Site, Kampala P.O. Box 27520, Uganda.
Centre for Tropical Medicine and Global Health, University of Oxford, Oxford OX3 7LG, UK.

Classifications MeSH