Regulation of m6A Methylation as a New Therapeutic Option against COVID-19.
COVID-19
SARS-CoV-2
epigenetics
fat mass and obesity-associated protein
m6A
methylation
rhein
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
08 Nov 2021
08 Nov 2021
Historique:
received:
30
09
2021
revised:
03
11
2021
accepted:
05
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
The rapid spread of SARS-CoV-2 and the resulting pandemic has led to a spasmodic search for approaches able to limit the diffusion of the disease. The epigenetic machinery has aroused considerable interest in the last decades, and much evidence has demonstrated that this type of modification could regulate the early stages of viral infection. Recently it was reported that N6-methyladenosine (m6A) influences SARS-CoV-2 replication, although its role remains to be further investigated. The knockdown of enzymes involved in the m6A pathway could represent an optimal strategy to deepen the epigenetic mechanism. In the present study, we blocked the catalytic activity of the fat mass and obesity-associated protein (FTO) by using the selective inhibitor rhein. We observed a strong broad-spectrum reduction of infectivity caused by various coronaviruses, including SARS-CoV-2. This effect could be due to the modulation of m6A levels and could allow identification of this modification as a new therapeutic target to treat SARS-CoV-2 infection.
Identifiants
pubmed: 34832917
pii: ph14111135
doi: 10.3390/ph14111135
pmc: PMC8625908
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
ACS Pharmacol Transl Sci. 2020 Nov 11;3(6):1361-1370
pubmed: 34778724
Nucleic Acids Res. 2018 Feb 16;46(3):1412-1423
pubmed: 29186567
Clin Epigenetics. 2019 Mar 27;11(1):55
pubmed: 30917875
Epigenetics. 2021 Mar;16(3):263-270
pubmed: 32686577
Cell Host Microbe. 2016 May 11;19(5):675-85
pubmed: 27117054
Evid Based Complement Alternat Med. 2015;2015:578107
pubmed: 26185519
mBio. 2021 Aug 31;12(4):e0106721
pubmed: 34225491
Viruses. 2021 Jun 29;13(7):
pubmed: 34209556
Front Endocrinol (Lausanne). 2018 Jul 30;9:396
pubmed: 30105001
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2752-2784
pubmed: 33829462
Cancer Res. 2020 Aug 15;80(16):3200-3214
pubmed: 32606006
PLoS One. 2018 Jan 31;13(1):e0191793
pubmed: 29385192
Rev Med Virol. 2014 Jul;24(4):223-41
pubmed: 24677359
Annu Rev Virol. 2019 Sep 29;6(1):235-253
pubmed: 31283446
Circulation. 2011 May 17;123(19):2145-56
pubmed: 21576679
Genes Dev. 2021 Jul 1;35(13-14):1005-1019
pubmed: 34168039
Genome. 2021 Apr;64(4):386-399
pubmed: 33086021
Autophagy. 2019 Aug;15(8):1419-1437
pubmed: 30870073
Cell Death Dis. 2021 Jul 23;12(8):732
pubmed: 34301919
Clin Epigenetics. 2020 Oct 21;12(1):156
pubmed: 33087172
Nat Rev Microbiol. 2020 Oct;18(10):559-570
pubmed: 32533130
Cell Host Microbe. 2016 Nov 9;20(5):654-665
pubmed: 27773535
PeerJ. 2020 Dec 21;8:e10639
pubmed: 33391888
Biomolecules. 2020 Jul 17;10(7):
pubmed: 32709063
J Clin Lab Anal. 2021 Mar;35(3):e23655
pubmed: 33314339
An Acad Bras Cienc. 2020 Jun 15;92(2):e20200466
pubmed: 32556054
Int J Antimicrob Agents. 2020 Mar;55(3):105924
pubmed: 32081636
Hepatology. 2020 Dec;72(6):2029-2050
pubmed: 32154934
Front Pharmacol. 2020 Aug 26;11:1224
pubmed: 32982720
Methods Mol Biol. 2015;1238:569-96
pubmed: 25421681
Front Pharmacol. 2016 Aug 17;7:247
pubmed: 27582705
Signal Transduct Target Ther. 2021 Aug 26;6(1):317
pubmed: 34446699
J Am Chem Soc. 2012 Oct 31;134(43):17963-71
pubmed: 23045983
Cell Res. 2021 Apr;31(4):404-414
pubmed: 33510385
Nat Chem Biol. 2020 Dec;16(12):1394-1402
pubmed: 32719557
Sci Rep. 2021 Feb 9;11(1):3379
pubmed: 33564039
Eur J Pharmacol. 2021 May 5;898:173988
pubmed: 33667455
Acta Pharm Sin B. 2021 Jan;11(1):222-236
pubmed: 33072499
Molecules. 2021 May 07;26(9):
pubmed: 34067026
IUBMB Life. 2020 Nov;72(11):2331-2354
pubmed: 32936531
Cell. 2018 Jan 11;172(1-2):90-105.e23
pubmed: 29249359
J Gen Virol. 2017 Sep;98(9):2207-2214
pubmed: 28869001
Cell Death Dis. 2020 Nov 8;11(11):960
pubmed: 33162550
Adv Drug Deliv Rev. 2021 May;172:314-338
pubmed: 33482248
Pharmacogenomics. 2020 Dec;21(18):1311-1329
pubmed: 33243086
Eur J Clin Microbiol Infect Dis. 2021 Aug;40(8):1587-1598
pubmed: 33939044