Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn's Disease.
Crohn’s disease
mesenchymal stem cells
perianal Crohn’s disease
perianal fistula
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
25 Oct 2021
25 Oct 2021
Historique:
received:
30
06
2021
revised:
12
10
2021
accepted:
19
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Perianal fistula in patients with Crohn's disease is an extremely challenging condition. The disease tends to reoccur, and with current treatment options, a large number of patients are left with active ailment and experience major morbidity. In recent years, hopeful results regarding local use of mesenchymal stem cells (MSCs) in perianal Crohn's disease have been published. Although to this day there are no clear guidelines determining optimal dosage, injections frequency and culture conditions, their efficiency has proven to be much higher than conventionally used methods. According to studies, they can effectively induce as well as maintain fistula closure. This approach also avoids common side effects related to conventional surgical treatment.
Identifiants
pubmed: 34833009
pii: life11111133
doi: 10.3390/life11111133
pmc: PMC8622588
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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