Cyclodextrin Complexation as a Way of Increasing the Aqueous Solubility and Stability of Carvedilol.
ITC
NMR
carvedilol
cyclodextrins
pharmaceutical solutions
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
20 Oct 2021
20 Oct 2021
Historique:
received:
23
09
2021
revised:
13
10
2021
accepted:
15
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
We studied the effect of several CDs on carvedilol's solubility and chemical stability in various aqueous media. Our present results show that it is possible to achieve a carvedilol concentration of 5 mg/mL (12.3 mM) in the presence of 5 eq of γCD or RAMEB in an aqueous medium with an acceptable acid pH (between 3.5 and 4.7). Carvedilol formed 1:1 inclusion complexes but those with RAMEB appear to be stronger (K = 317 M
Identifiants
pubmed: 34834163
pii: pharmaceutics13111746
doi: 10.3390/pharmaceutics13111746
pmc: PMC8620534
pii:
doi:
Types de publication
Journal Article
Langues
eng
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