Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design.
CTCs
NSCLCs
curcumin
flavonoids
metastasis suppression
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
05 Nov 2021
05 Nov 2021
Historique:
received:
27
09
2021
revised:
27
10
2021
accepted:
30
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Designing optimal (neo)adjuvant therapy is a crucial aspect of the treatment of non-small-cell lung carcinoma (NSCLC). Standard methods of chemotherapy, radiotherapy, and immunotherapy represent effective strategies for treatment. However, in some cases with high metastatic activity and high levels of circulating tumour cells (CTCs), the efficacy of standard treatment methods is insufficient and results in treatment failure and reduced patient survival. CTCs are seen not only as an isolated phenomenon but also a key inherent part of the formation of metastasis and a key factor in cancer death. This review discusses the impact of NSCLC therapy strategies based on a meta-analysis of clinical studies. In addition, possible therapeutic strategies for repression when standard methods fail, such as the administration of low-toxicity natural anticancer agents targeting these phenomena (curcumin and flavonoids), are also discussed. These strategies are presented in the context of key mechanisms of tumour biology with a strong influence on CTC spread and metastasis (mechanisms related to tumour-associated and -infiltrating cells, epithelial-mesenchymal transition, and migration of cancer cells).
Identifiants
pubmed: 34834295
pii: pharmaceutics13111879
doi: 10.3390/pharmaceutics13111879
pmc: PMC8619417
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Charles University
ID : SVV260521
Organisme : Charles University
ID : UNCE 204064
Organisme : Charles University
ID : Progress Q26/LF1
Organisme : Charles University
ID : Progress Q27/LF1
Organisme : Ministry of Education Youth and Sports
ID : LM2018133 (EATRIS-CZ)
Organisme : Ministry of Health
ID : RVO-VFN-64165/2012
Organisme : Technology Agency of the Czech Republic
ID : TN01000013
Organisme : Technology Agency of the Czech Republic
ID : FW02020128
Organisme : Ministry of Health
ID : NU21-08-00407
Organisme : Operational Programme Research, Development and Education
ID : CZ.02.1.01/0.0/0.0/16_019/0000785
Références
Cell. 2014 Aug 28;158(5):1110-1122
pubmed: 25171411
Phytother Res. 2014 Mar;28(3):444-50
pubmed: 23775598
Nat Mater. 2021 Nov;20(11):1469-1479
pubmed: 34226688
Cell. 2013 Nov 7;155(4):750-64
pubmed: 24209616
Nutrients. 2019 Dec 06;11(12):
pubmed: 31817718
Oncotarget. 2015 Sep 8;6(26):21918-33
pubmed: 26116834
Food Funct. 2018 Apr 25;9(4):2025-2031
pubmed: 29541713
Clin Transl Oncol. 2020 Jun;22(6):870-877
pubmed: 31473984
Oncol Res. 2012;20(2-3):131-7
pubmed: 23193919
Int J Oncol. 1995 Jan;6(1):147-51
pubmed: 21556515
J Cell Physiol. 2020 Nov;235(11):7970-7981
pubmed: 31943177
Complement Ther Med. 2020 Jun;51:102447
pubmed: 32507446
Clin Cancer Res. 2013 Mar 1;19(5):1116-25
pubmed: 23322899
Mol Cancer Ther. 2007 Feb;6(2):471-83
pubmed: 17308046
Cancer Lett. 2013 Jul 10;335(1):205-13
pubmed: 23419524
Biotechnol Adv. 2018 Jul - Aug;36(4):1063-1078
pubmed: 29559380
Sci Rep. 2017 Nov 13;7(1):15441
pubmed: 29133857
Oncotarget. 2020 Mar 24;11(12):1037-1050
pubmed: 32256977
Cancer Manag Res. 2019 Dec 27;11:10791-10800
pubmed: 31920388
Biomed Pharmacother. 2020 May;125:109922
pubmed: 32007919
Lung Cancer. 2003 Aug;41(2):123-30
pubmed: 12871775
BMC Cancer. 2020 Sep 11;20(1):873
pubmed: 32917154
J Biol Chem. 2004 Mar 5;279(10):8567-76
pubmed: 14676209
J Cancer. 2016 Jun 03;7(9):1095-104
pubmed: 27326253
Br J Cancer. 2021 Feb;124(3):539-551
pubmed: 33106581
PLoS One. 2014 Jan 21;9(1):e85350
pubmed: 24465542
Cancers (Basel). 2019 Jun 11;11(6):
pubmed: 31212653
Cancer Prev Res (Phila). 2011 Mar;4(3):354-64
pubmed: 21372035
J Cell Physiol. 2018 Apr;233(4):3004-3015
pubmed: 28617957
Cancer Lett. 2021 Jan 28;497:41-53
pubmed: 32987138
PLoS One. 2011 Feb 10;6(2):e16979
pubmed: 21347332
Lung Cancer. 2017 Oct;112:200-215
pubmed: 29191596
Biochim Biophys Acta. 2007 Jul;1773(7):1116-23
pubmed: 17555831
J Thorac Oncol. 2007 Apr;2(4):299-305
pubmed: 17409801
Fitoterapia. 2020 Jun;143:104590
pubmed: 32272164
Oncotarget. 2017 May 16;8(20):32523-32535
pubmed: 28430645
Cancer Res. 2021 Aug 1;81(15):4110-4123
pubmed: 34045187
Cancer Prev Res (Phila). 2016 Aug;9(8):683-91
pubmed: 27267893
Int J Oncol. 2012 May;40(5):1561-8
pubmed: 22266952
Int J Mol Sci. 2020 Oct 26;21(21):
pubmed: 33114676
Eur Rev Med Pharmacol Sci. 2018 Nov;22(21):7492-7499
pubmed: 30468498
Indian J Dent Res. 2020 Sep-Oct;31(5):718-727
pubmed: 33433509
Histol Histopathol. 2014 Jan;29(1):21-31
pubmed: 23939555
BMC Cancer. 2013 Sep 17;13:421
pubmed: 24044575
J Agric Food Chem. 2009 Oct 14;57(19):8933-41
pubmed: 19725538
Arch Biochem Biophys. 2020 Nov 15;694:108613
pubmed: 33010228
Rev Physiol Biochem Pharmacol. 2019;176:107-129
pubmed: 29728868
Arch Oral Biol. 2018 Aug;92:32-37
pubmed: 29751146
Neoplasia. 2013 Jun;15(6):631-40
pubmed: 23730211
Med Sci Monit. 2018 Apr 10;24:2126-2133
pubmed: 29632297
J Cell Biochem. 2018 Feb;119(2):1420-1428
pubmed: 28731226
Biomolecules. 2019 May 06;9(5):
pubmed: 31064104
Complement Ther Med. 2020 Mar;49:102322
pubmed: 32147075
J Cell Physiol. 2007 Jun;211(3):771-80
pubmed: 17299794
Cancer Res. 2020 Oct 1;80(19):4025-4036
pubmed: 32616502
Biochem Pharmacol. 2010 Jun 1;79(11):1600-9
pubmed: 20153296
Trends Cancer. 2017 Jun;3(6):391-406
pubmed: 28670628
JAMA Surg. 2019 Jul 1;154(7):e190972
pubmed: 31042283
Cancer Prev Res (Phila). 2010 Aug;3(8):953-62
pubmed: 20606042
Sci Rep. 2015 Aug 24;5:13429
pubmed: 26299580
PLoS One. 2019 Jul 26;14(7):e0220306
pubmed: 31348821
J Proteomics. 2018 Jun 30;182:65-72
pubmed: 29751106
Cell Oncol (Dordr). 2019 Aug;42(4):405-421
pubmed: 30980365
Cancer Res. 2015 Nov 15;75(22):4681-7
pubmed: 26471358
Future Oncol. 2019 Apr;15(11):1243-1253
pubmed: 30843426
Phytother Res. 2020 Oct;34(10):2557-2576
pubmed: 32307773
Oncotarget. 2016 May 24;7(21):30420-39
pubmed: 27050372
Cancer Res. 2019 Jul 15;79(14):3651-3661
pubmed: 31088838
Clin Cancer Res. 2012 Apr 15;18(8):2391-401
pubmed: 22492982
Nutrients. 2020 Sep 29;12(10):
pubmed: 33003518
Lab Invest. 2008 Jul;88(7):740-9
pubmed: 18490895
Cancer. 2013 Jan 15;119(2):363-70
pubmed: 22760587
JCI Insight. 2019 Feb 21;4(4):
pubmed: 30652973
Immunology. 2015 Apr;144(4):561-73
pubmed: 25284464
Mol Med Rep. 2015 Oct;12(4):5796-806
pubmed: 26238746
Am J Transl Res. 2017 Apr 15;9(4):1866-1875
pubmed: 28469791
PLoS One. 2011;6(9):e23833
pubmed: 21915264
Phytother Res. 2014 Oct;28(10):1461-7
pubmed: 24648302
Cancer Res. 2007 Oct 15;67(20):9685-93
pubmed: 17942898
Int J Mol Sci. 2021 Jun 30;22(13):
pubmed: 34209461
PLoS One. 2015 Dec 10;10(12):e0144462
pubmed: 26656720
Lung Cancer. 2018 Jun;120:108-112
pubmed: 29748004
Cancer Sci. 2014 Aug;105(8):1023-31
pubmed: 24841832
Nutr Cancer. 2018 Apr;70(3):334-349
pubmed: 29570987
Radiother Oncol. 2015 Mar;114(3):351-6
pubmed: 25769379
Acta Pharmacol Sin. 2016 Apr;37(4):505-18
pubmed: 26948085
Int J Mol Med. 2020 Dec;46(6):2216-2224
pubmed: 33125096
Chest. 2013 May;143(5 Suppl):e1S-e29S
pubmed: 23649439
J Pharmacopuncture. 2015 Mar;18(1):19-26
pubmed: 25830055
Carcinogenesis. 2007 Oct;28(10):2114-21
pubmed: 17548900
Oncotarget. 2015 Dec 29;6(42):44781-93
pubmed: 26575023
Adv Exp Med Biol. 2017;994:229-245
pubmed: 28560677
Am J Transl Res. 2016 Nov 15;8(11):4857-4868
pubmed: 27904686
J Thorac Oncol. 2012 Jul;7(7):1091-100
pubmed: 22534817
Cancer Sci. 2020 Feb;111(2):441-450
pubmed: 31821662
Pharmacol Ther. 2014 Feb;141(2):125-39
pubmed: 24076269
Cancer Lett. 2017 Jan 28;385:51-54
pubmed: 27840244
Molecules. 2020 Nov 18;25(22):
pubmed: 33217990
Biochim Biophys Acta. 2014 Sep;1842(9):1742-54
pubmed: 24970744
Cancer Invest. 2011 Mar;29(3):208-13
pubmed: 21314329
Eur J Cardiothorac Surg. 2003 Apr;23(4):451-6
pubmed: 12694758
Hum Exp Toxicol. 2010 Jun;29(6):513-24
pubmed: 20056736
Sci Transl Med. 2016 Nov 2;8(363):363ra147
pubmed: 27807282
Anticancer Agents Med Chem. 2017;17(6):859-864
pubmed: 27671306
Oncoimmunology. 2012 Mar 1;1(2):162-171
pubmed: 22720237
Ann Oncol. 2017 Jul 1;28(suppl_4):iv1-iv21
pubmed: 28881918
Int J Clin Oncol. 2017 Jun;22(3):421-430
pubmed: 28238187
Oncol Rep. 2015 Jun;33(6):2972-80
pubmed: 25845434
Food Funct. 2020 Nov 18;11(11):9776-9788
pubmed: 33078819
Int J Mol Sci. 2020 Sep 10;21(18):
pubmed: 32927725
Int Immunopharmacol. 2016 Oct;39:265-272
pubmed: 27497194
Cancer Lett. 2018 Jan 1;412:10-20
pubmed: 29024813
Int J Oncol. 2015 Dec;47(6):2064-72
pubmed: 26499200
Sci Rep. 2020 Jan 17;10(1):539
pubmed: 31953491
Cancers (Basel). 2021 Apr 09;13(8):
pubmed: 33918661
Mol Oncol. 2013 Oct;7(5):976-86
pubmed: 23895914
Cancer Microenviron. 2016 Apr;9(1):1-11
pubmed: 26319408
Int J Clin Exp Pathol. 2010 Aug 05;3(7):705-9
pubmed: 20830241
PLoS One. 2013 Nov 04;8(11):e78070
pubmed: 24223761
Nat Commun. 2021 Aug 11;12(1):4867
pubmed: 34381029
Anticancer Res. 2014 Apr;34(4):1857-64
pubmed: 24692720
Cancers (Basel). 2021 Mar 16;13(6):
pubmed: 33809574
Sci Rep. 2017 Sep 6;7(1):10613
pubmed: 28878389
Int J Mol Sci. 2017 Oct 07;18(10):
pubmed: 28991167
Br J Nutr. 2016 Dec;116(11):1901-1911
pubmed: 27923410
Int J Cancer. 2007 May 1;120(9):2019-27
pubmed: 17266043
Oncol Rep. 2015 Nov;34(5):2351-6
pubmed: 26323894
Toxicol Appl Pharmacol. 2008 Jun 15;229(3):386-98
pubmed: 18336852
Mol Ther. 2016 Feb;24(2):364-374
pubmed: 26334519
Exp Ther Med. 2018 Mar;15(3):2667-2673
pubmed: 29467859
Cancer Treat Rev. 2014 May;40(4):558-66
pubmed: 24176790
Biofactors. 2015 Nov-Dec;41(6):431-42
pubmed: 26643788
Clin Exp Metastasis. 2012 Jan;29(1):39-50
pubmed: 21964676
Clin Cancer Res. 2016 Dec 15;22(24):6010-6020
pubmed: 27281561
Nat Rev Immunol. 2009 Mar;9(3):162-74
pubmed: 19197294
Clin Cancer Res. 2005 Jan 1;11(1):173-9
pubmed: 15671543
Fitoterapia. 2019 Sep;137:104275
pubmed: 31351126
Cancer Lett. 2019 Nov 1;464:56-61
pubmed: 31437477
Int J Nanomedicine. 2020 Jun 19;15:4417-4429
pubmed: 32606686
Biofabrication. 2018 Mar 28;10(3):035004
pubmed: 29595143
Physiol Int. 2018 Sep 1;105(3):233-246
pubmed: 30282485
J Exp Clin Cancer Res. 2018 Jul 25;37(1):168
pubmed: 30041669
Cancers (Basel). 2021 Jun 01;13(11):
pubmed: 34206049
J Cell Physiol. 2020 Nov;235(11):7696-7708
pubmed: 32324275
Free Radic Res. 2021 Mar;55(3):296-303
pubmed: 33818251
Cancers (Basel). 2019 Apr 05;11(4):
pubmed: 30959764
In Vitro Cell Dev Biol Anim. 2014 Oct;50(9):840-50
pubmed: 24938356
PLoS One. 2015 Oct 28;10(10):e0141602
pubmed: 26509633
Int J Cancer. 2012 Apr 1;130(7):1695-705
pubmed: 21618507
Prostate. 2010 Jul 1;70(10):1127-33
pubmed: 20503397
Radiother Oncol. 2014 Jan;110(1):132-6
pubmed: 24444526
Med Oncol. 2017 Jan;34(1):12
pubmed: 28012133
Molecules. 2018 Jan 18;23(1):
pubmed: 29346317
J Biol Chem. 2013 Sep 20;288(38):27343-27357
pubmed: 23902763
PLoS One. 2017 Feb 24;12(2):e0172787
pubmed: 28235063
Chin J Cancer Res. 2016 Aug;28(4):452-60
pubmed: 27647974
J Nutr Biochem. 2014 Feb;25(2):241-9
pubmed: 24445050
Eur Rev Med Pharmacol Sci. 2015;19(9):1736-43
pubmed: 26004618
J Thorac Oncol. 2008 Apr;3(4):374-9
pubmed: 18379355
Cell Physiol Biochem. 2018;51(1):315-336
pubmed: 30453281
Mol Cancer. 2010 Jul 07;9:179
pubmed: 20609236
Transl Lung Cancer Res. 2017 Aug;6(4):486-498
pubmed: 28904891
Int Immunopharmacol. 2017 Aug;49:30-37
pubmed: 28550732
J Control Release. 2013 Dec 28;172(3):832-40
pubmed: 24036260
Clin Exp Metastasis. 2000;18(7):539-45
pubmed: 11688958
Med Hypotheses. 2016 Aug;93:138-9
pubmed: 27372873
Free Radic Biol Med. 2017 Jun;107:258-265
pubmed: 27871818
Chem Biol Interact. 2019 Apr 25;303:14-21
pubmed: 30802432
J Nat Prod. 2013 Mar 22;76(3):316-21
pubmed: 23145932
Mol Cancer. 2019 Sep 2;18(1):132
pubmed: 31477121
J Thorac Oncol. 2012 Feb;7(2):306-15
pubmed: 22173704
Immunobiology. 2017 Jan;222(1):55-65
pubmed: 26705936
Medicine (Baltimore). 1999 Sep;78(5):285-91
pubmed: 10499070
Eur J Pharm Sci. 2019 Jun 15;134:246-255
pubmed: 31034984
Clin Exp Metastasis. 2021 Aug;38(4):373-399
pubmed: 34254215
Adv Exp Med Biol. 2016;890:57-74
pubmed: 26703799
Nutrients. 2016 Sep 09;8(9):
pubmed: 27618095
Int J Mol Sci. 2020 Aug 10;21(16):
pubmed: 32784973
J BUON. 2019 May-Jun;24(3):883-888
pubmed: 31424637
Adv Exp Med Biol. 2016;893:1-19
pubmed: 26667336
Nat Rev Cancer. 2019 Oct;19(10):553-567
pubmed: 31455893
Clin Cancer Res. 2005 Dec 1;11(23):8288-94
pubmed: 16322287
Sci Rep. 2019 Jan 24;9(1):491
pubmed: 30679571
Cancer Med. 2018 Dec;7(12):5910-5919
pubmed: 30565869
Biochem Pharmacol. 2021 Jun;188:114589
pubmed: 33932470
Oncol Lett. 2019 Sep;18(3):2537-2547
pubmed: 31452741
Cell Death Dis. 2021 Sep 8;12(9):840
pubmed: 34497265
J Cell Biochem. 2019 Jan;120(1):872-881
pubmed: 30132982
Spec Care Dentist. 2019 Mar;39(2):166-172
pubmed: 30761565
Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2202-6
pubmed: 19661078
Nat Biotechnol. 2013 Jun;31(6):539-44
pubmed: 23609047
Oncol Res. 2017 Nov 2;25(9):1601-1606
pubmed: 28474575
Mol Cancer Ther. 2012 Oct;11(10):2254-64
pubmed: 22891040
Int J Mol Sci. 2021 Jan 11;22(2):
pubmed: 33440733
J Cell Physiol. 2005 Feb;202(2):464-73
pubmed: 15389584
Clin Nutr. 2011 Aug;30(4):506-12
pubmed: 21324570
Carcinogenesis. 2013 Mar;34(3):638-46
pubmed: 23172668
Oncotarget. 2015 Aug 28;6(25):21315-27
pubmed: 26087179
Cancers (Basel). 2020 Jul 05;12(7):
pubmed: 32635637
Curr Drug Deliv. 2018 Feb 14;15(2):286-295
pubmed: 29065834
Mol Cancer Ther. 2017 Oct;16(10):2234-2245
pubmed: 28729401
Sci Rep. 2019 Jan 24;9(1):566
pubmed: 30679441
Oncogene. 2003 Jul 10;22(28):4314-32
pubmed: 12853969
J Clin Invest. 2007 Dec;117(12):3846-56
pubmed: 18060032
J Cancer Res Clin Oncol. 2013 Apr;139(4):563-72
pubmed: 23224523
Molecules. 2018 Aug 18;23(8):
pubmed: 30126206
Cancer Sci. 2018 Aug;109(8):2539-2548
pubmed: 29900633
Nature. 2005 Dec 8;438(7069):820-7
pubmed: 16341007
Clin Exp Metastasis. 2008;25(5):531-6
pubmed: 18357506
Cancer Med. 2016 Oct;5(10):2886-2898
pubmed: 27600331
Biomed Pharmacother. 2019 Oct;118:109278
pubmed: 31387004
Mol Oncol. 2020 Apr;14(4):865-881
pubmed: 31981446
Neuro Oncol. 2016 Apr;18(4):486-96
pubmed: 26995790
Cancer Treat Rev. 2020 Apr;85:101978
pubmed: 32062493
Anticancer Res. 2013 May;33(5):2001-9
pubmed: 23645749
Clin Transl Oncol. 2014 Jul;16(7):637-43
pubmed: 24217975
Biomedicines. 2021 Jun 09;9(6):
pubmed: 34207755
Drug Des Devel Ther. 2017 Feb 14;11:431-439
pubmed: 28243065
J Natl Cancer Inst. 2018 Jan 1;110(1):
pubmed: 28922791
Cancer Manag Res. 2019 Mar 27;11:2425-2439
pubmed: 30988640
Lung Cancer. 2011 Nov;74(2):305-9
pubmed: 21726917
JAMA Surg. 2014 May;149(5):482-5
pubmed: 24599353
Biofactors. 2013 Mar-Apr;39(2):221-32
pubmed: 23233214
Trends Cancer. 2019 Dec;5(12):755-756
pubmed: 31813449
Molecules. 2018 Apr 20;23(4):
pubmed: 29677167
J Cell Physiol. 2019 May;234(5):5728-5740
pubmed: 30317564
Respir Investig. 2021 Jul;59(4):535-544
pubmed: 33934994
Breast Cancer Res. 2019 Dec 4;21(1):137
pubmed: 31801599
CNS Neurol Disord Drug Targets. 2017;16(3):346-350
pubmed: 27592626
Oncol Lett. 2020 Nov;20(5):141
pubmed: 32934709
Hum Exp Toxicol. 2018 Jun;37(6):618-625
pubmed: 28681665
Sci Rep. 2016 Jun 15;6:28010
pubmed: 27302574
Cancer Res. 2020 Jan 15;80(2):291-303
pubmed: 31727628
Am J Transl Res. 2017 Aug 15;9(8):3633-3641
pubmed: 28861154
Cell Rep. 2020 Sep 8;32(10):108105
pubmed: 32905777
Biomolecules. 2020 Sep 02;10(9):
pubmed: 32887473
Biol Pharm Bull. 2013;36(6):944-51
pubmed: 23727915
Zhongguo Fei Ai Za Zhi. 2020 Nov 20;23(11):976-982
pubmed: 32773010
J Thorac Oncol. 2011 Jan;6(1):209-17
pubmed: 21107292
Int J Cancer. 2017 Aug 1;141(3):614-620
pubmed: 28445609
Biochem Pharmacol. 1998 Mar 15;55(6):775-83
pubmed: 9586949
Int Ophthalmol. 2020 Oct;40(10):2435-2440
pubmed: 32399774
Sci Rep. 2016 Jul 01;6:28910
pubmed: 27363678
Mol Cell Endocrinol. 2017 Aug 15;451:15-23
pubmed: 28088467
Mol Diagn Ther. 2021 Sep;25(5):549-562
pubmed: 34287797
J Nat Prod. 2011 Apr 25;74(4):664-9
pubmed: 21413691
Cancer Microenviron. 2014 Dec;7(3):153-60
pubmed: 25337680
J Cell Biochem. 2008 Jun 1;104(3):733-44
pubmed: 18253935
Cancer Chemother Pharmacol. 2010 Jan;65(2):277-87
pubmed: 19466611
Nanomaterials (Basel). 2021 Jun 30;11(7):
pubmed: 34209111
Mol Aspects Med. 2020 Apr;72:100816
pubmed: 31377345
Oncol Lett. 2018 Nov;16(5):6756-6762
pubmed: 30405819
PLoS One. 2011;6(8):e23756
pubmed: 21858220
Biomed Res. 2013;34(6):301-8
pubmed: 24389406
Int J Mol Sci. 2013 Jun 05;14(6):12023-36
pubmed: 23739680
Transl Lung Cancer Res. 2021 Apr;10(4):1889-1916
pubmed: 34012800
Int J Cancer. 2016 Dec 15;139(12):2838-2849
pubmed: 27543754
Cancer. 2020 Apr 15;126(8):1668-1682
pubmed: 32022261
Biochimie. 2013 Jun;95(6):1297-309
pubmed: 23485682
Biol Chem. 2019 May 27;400(6):777-785
pubmed: 30699065
PLoS One. 2013 Jun 25;8(6):e65896
pubmed: 23825527
Trends Cancer. 2021 Nov;7(11):1020-1032
pubmed: 34481763
Nutr Cancer. 2001;39(1):85-95
pubmed: 11588907
Annu Rev Pathol. 2011;6:49-69
pubmed: 20887192
Oncotarget. 2016 Dec 27;7(52):87081-87090
pubmed: 27894084
J Nutrigenet Nutrigenomics. 2013;6(3):169-78
pubmed: 24008975
Respir Res. 2015 Nov 09;16:138
pubmed: 26553068
Semin Intervent Radiol. 2013 Jun;30(2):191-8
pubmed: 24436536
Cancers (Basel). 2019 Jun 17;11(6):
pubmed: 31212989
FASEB J. 2018 Jan;32(1):276-288
pubmed: 28899878
Oncotarget. 2017 Apr 4;8(14):22625-22639
pubmed: 28186986
Bioorg Med Chem. 2009 Jan 15;17(2):614-20
pubmed: 19097913
Cancer Lett. 2020 Jan 28;469:355-366
pubmed: 31678168
Mol Cancer. 2018 Feb 19;17(1):29
pubmed: 29455654
J BUON. 2018 Jul-Aug;23(4):1077-1081
pubmed: 30358214
Clin Exp Metastasis. 2008;25(6):621-8
pubmed: 18600305
Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1746-1758
pubmed: 28648644
J Nutr Sci Vitaminol (Tokyo). 2021;67(4):249-252
pubmed: 34471000
PLoS One. 2012;7(5):e37960
pubmed: 22662257
Ther Adv Respir Dis. 2016 Jun;10(3):265-74
pubmed: 26893312
Radiother Oncol. 2019 Aug;137:186-191
pubmed: 30898322
Biochem Biophys Res Commun. 2015 Oct 23;466(3):493-8
pubmed: 26375501
Eur J Cancer. 2011 Jul;47(10):1546-55
pubmed: 21565487
Cancer Res. 2017 Sep 15;77(18):5194-5206
pubmed: 28716896
Cancer Gene Ther. 2009 Aug;16(8):620-4
pubmed: 19287371
Cancer Res. 2013 May 15;73(10):2965-75
pubmed: 23471846
Nutr Cancer. 2000;37(1):49-54
pubmed: 10965519
Cells. 2019 Aug 01;8(8):
pubmed: 31374957
Thorac Cancer. 2017 Sep;8(5):461-470
pubmed: 28660665
Biochem Biophys Res Commun. 2005 Aug 26;334(2):313-8
pubmed: 16005433
Molecules. 2020 Oct 20;25(20):
pubmed: 33092261
Phytomedicine. 2012 Jun 15;19(8-9):779-87
pubmed: 22483553
Oncoimmunology. 2017 Apr 20;6(12):e1315488
pubmed: 29209560
Clin Cancer Res. 2016 Mar 1;22(5):1103-10
pubmed: 26446944
Oncol Rep. 2015 Nov;34(5):2782-9
pubmed: 26351877
J Clin Oncol. 2011 Apr 20;29(12):1556-63
pubmed: 21422424
Breast Cancer Res Treat. 2014 Apr;144(3):551-60
pubmed: 24610032
Int J Mol Sci. 2020 Dec 12;21(24):
pubmed: 33322711
J Nutr Biochem. 2014 Feb;25(2):177-85
pubmed: 24445042
Oral Dis. 2020 Oct;26(7):1375-1383
pubmed: 32060973
Front Cell Dev Biol. 2021 Sep 20;9:733627
pubmed: 34616739
Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1139-1145
pubmed: 28446544
Int J Mol Sci. 2019 Sep 03;20(17):
pubmed: 31484342
J Immunother Cancer. 2019 Jul 10;7(1):173
pubmed: 31291995
J Cell Biol. 2011 Feb 7;192(3):373-82
pubmed: 21300848
Cancer Prev Res (Phila). 2009 Jul;2(7):673-82
pubmed: 19542190
Sci Rep. 2017 May 17;7(1):2027
pubmed: 28515486
J Med Food. 2020 Jan;23(1):43-49
pubmed: 31747326
J Clin Oncol. 2014 Nov 1;32(31):3483-9
pubmed: 24888818
Cancer Med. 2021 Apr;10(7):2332-2340
pubmed: 33666378
FEBS Lett. 2001 Apr 20;495(1-2):131-6
pubmed: 11322961
Ann Oncol. 2017 Jul 1;28(7):1523-1531
pubmed: 28633480
Cancer Res. 2018 Nov 1;78(21):6040-6047
pubmed: 30327380
Biochem Biophys Res Commun. 2018 Sep 10;503(3):1723-1731
pubmed: 30075845
Biomolecules. 2020 May 29;10(6):
pubmed: 32486019
Biochem Biophys Res Commun. 2018 Jan 1;495(1):360-367
pubmed: 29101033
Sci Rep. 2018 Feb 7;8(1):2592
pubmed: 29416054
Clin Cancer Res. 2020 May 15;26(10):2372-2380
pubmed: 31969332
J Thorac Oncol. 2017 Jan;12(1):43-53
pubmed: 27543256
Life Sci. 2021 Jan 1;264:118720
pubmed: 33157089
Cancer Immunol Immunother. 2018 May;67(5):761-774
pubmed: 29453519
Expert Rev Mol Diagn. 2019 Aug;19(8):683-694
pubmed: 31305173
Int J Oncol. 2020 Aug;57(2):445-455
pubmed: 32626932
Lung Cancer (Auckl). 2021 Feb 05;12:1-10
pubmed: 33574724
Respirology. 2016 Apr;21(3):519-25
pubmed: 26661896
Oncol Lett. 2021 Apr;21(4):286
pubmed: 33732362
Cancer Res. 2020 Jun 1;80(11):2257-2272
pubmed: 32193288
J Recept Signal Transduct Res. 2019 Feb;39(1):18-27
pubmed: 31223050
Pharm Res. 2010 Jun;27(6):1061-5
pubmed: 20372995
Sci Rep. 2016 Dec 07;6:38343
pubmed: 27924826
Sci Rep. 2019 Mar 26;9(1):5220
pubmed: 30914716
Mol Nutr Food Res. 2010 Aug;54(8):1192-201
pubmed: 20087857
Immunol Rev. 2008 Apr;222:129-44
pubmed: 18363998
Surg Today. 2012 Jan;42(1):1-7
pubmed: 22116397
Int J Mol Sci. 2020 Mar 03;21(5):
pubmed: 32138321
J Cell Physiol. 2018 Jun;233(6):4852-4863
pubmed: 29152741
Clin Lung Cancer. 2021 May;22(3):e451-e465
pubmed: 32798130
Mol Cancer Res. 2013 Oct;11(10):1248-57
pubmed: 23744981
Sci Rep. 2020 Mar 20;10(1):5163
pubmed: 32198390
Oncotarget. 2016 Jan 5;7(1):446-58
pubmed: 26623559
Int J Oncol. 2014 May;44(5):1643-51
pubmed: 24573038
Oncotarget. 2016 Feb 9;7(6):6626-38
pubmed: 26675547
PLoS One. 2015 Jan 30;10(1):e0118060
pubmed: 25635394
Cancer Res. 2020 Jan 1;80(1):57-68
pubmed: 31690669
Asian Pac J Cancer Prev. ;18(8):2275-2285
pubmed: 28843267
Sci Rep. 2016 Aug 24;6:31726
pubmed: 27553175
Exp Ther Med. 2020 Mar;19(3):1997-2007
pubmed: 32104259
Nutrients. 2020 Apr 10;12(4):
pubmed: 32290071
Med Sci Monit. 2020 Mar 30;26:e920537
pubmed: 32225128
PLoS One. 2013 Jun 28;8(6):e67466
pubmed: 23840710
Phys Biol. 2012 Feb;9(1):016005
pubmed: 22307026
Onco Targets Ther. 2017 May 22;10:2675-2683
pubmed: 28579805
Cancer Res. 2001 Mar 1;61(5):2183-8
pubmed: 11280784
Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8
pubmed: 16757216
Phytother Res. 2021 Jan;35(1):78-94
pubmed: 32658314
Sci Rep. 2016 Jul 13;6:29521
pubmed: 27405665
BMC Cancer. 2016 Jul 07;16:419
pubmed: 27387344
Cancer Chemother Pharmacol. 2013 Mar;71(3):713-25
pubmed: 23292117
Asian Pac J Cancer Prev. 2012;13(11):5709-14
pubmed: 23317243
Mol Cell Biochem. 2015 Feb;400(1-2):51-6
pubmed: 25359171
Int J Clin Exp Pathol. 2015 Jan 01;8(1):25-37
pubmed: 25755690
Am J Cancer Res. 2017 Jan 01;7(1):125-133
pubmed: 28123853
Cell Commun Signal. 2019 May 17;17(1):47
pubmed: 31101063
Oncotarget. 2015 Apr 30;6(12):10016-29
pubmed: 25881542
Lung Cancer. 2011 Feb;71(2):209-16
pubmed: 20471712
Cancer Sci. 2011 Feb;102(2):317-23
pubmed: 21199169
Zentralbl Chir. 2017 Feb;142(1):96-103
pubmed: 27027279
Cancer Sci. 2018 Apr;109(4):944-955
pubmed: 29383798
Mol Med Rep. 2018 Jan;17(1):2019-2025
pubmed: 29138815
Recent Results Cancer Res. 2020;215:105-125
pubmed: 31605226
Molecules. 2019 Mar 21;24(6):
pubmed: 30901869
Crit Rev Immunol. 2010;30(6):529-45
pubmed: 21175416
Annu Rev Cell Dev Biol. 2014;30:255-89
pubmed: 25288114
PLoS One. 2016 Jul 26;11(7):e0159397
pubmed: 27459545
Wiad Lek. 2017;70(5):946-952
pubmed: 29203747
Clin Chem. 2012 May;58(5):936-40
pubmed: 22205690
Crit Rev Food Sci Nutr. 2019;59(6):992-1007
pubmed: 30795687
Anticancer Res. 2001 Jul-Aug;21(4B):2895-900
pubmed: 11712783
Inflammation. 2019 Aug;42(4):1441-1455
pubmed: 31028577
Front Biosci (Landmark Ed). 2011 Jan 01;16:1172-85
pubmed: 21196225
Oncol Lett. 2018 Sep;16(3):3045-3053
pubmed: 30127895
Clin Cancer Res. 2018 Nov 1;24(21):5407-5421
pubmed: 29959142
Onco Targets Ther. 2020 Apr 22;13:3375-3387
pubmed: 32425545
Oncogenesis. 2017 Oct 2;6(10):e384
pubmed: 28967875
Cancer Manag Res. 2020 Feb 05;12:841-854
pubmed: 32104066
Wien Med Wochenschr. 2015 Oct;165(19-20):379-86
pubmed: 26289596
Phys Biol. 2012 Feb;9(1):016004
pubmed: 22306961
Phytomedicine. 2020 Feb;67:153138
pubmed: 31881478
Br J Cancer. 2016 Jul 26;115(3):346-53
pubmed: 27336603
Curr Drug Targets. 2017;18(2):135-146
pubmed: 26521777
PLoS One. 2014 Aug 19;9(8):e103883
pubmed: 25137181
PLoS One. 2014 Oct 31;9(10):e111597
pubmed: 25360587
Nutrients. 2018 Jul 01;10(7):
pubmed: 29966389
J Natl Cancer Inst. 2004 Dec 1;96(23):1743-50
pubmed: 15572756
J Thorac Oncol. 2015 Aug;10(8):1163-71
pubmed: 26200270
Oxid Med Cell Longev. 2018 Mar 20;2018:9698258
pubmed: 29743988
Cancer Genomics Proteomics. 2016 11-12;13(6):475-482
pubmed: 27807070
Mol Pharm. 2016 Feb 1;13(2):404-19
pubmed: 26716471
Sci Rep. 2020 Feb 12;10(1):2444
pubmed: 32051483
Prostate. 2019 May;79(6):614-621
pubmed: 30671976
Ther Clin Risk Manag. 2017 Oct 11;13:1363-1374
pubmed: 29066904
Cells. 2020 May 25;9(5):
pubmed: 32466213
Lung Cancer. 2021 Oct;160:152-165
pubmed: 34417059
Nat Commun. 2020 Dec 9;11(1):6311
pubmed: 33298946
Mol Med Rep. 2008 Nov-Dec;1(6):775-9
pubmed: 21479484
Curr Pharm Des. 2017;23(13):2002-2008
pubmed: 28117012
Cancer Treat Rev. 2017 Nov;60:24-31
pubmed: 28866366
Ann Oncol. 2018 Jan 1;29(1):193-199
pubmed: 29361135
Oncogene. 2017 Feb 2;36(5):639-651
pubmed: 27345402
J Contemp Dent Pract. 2020 May 1;21(5):521-531
pubmed: 32690834
Eur J Med Chem. 2021 Jan 15;210:112995
pubmed: 33243531
Pharmacol Res. 2018 Jun;132:72-79
pubmed: 29614381
Nat Metab. 2020 Apr;2(4):318-334
pubmed: 32691018
Cancer Sci. 2019 Sep;110(9):2773-2782
pubmed: 31348594
Ther Adv Med Oncol. 2018 Jan 15;10:1758834017750121
pubmed: 29383038
Lung Cancer. 2018 Oct;124:53-64
pubmed: 30268480
Biochem Pharmacol. 2014 Feb 1;87(3):424-34
pubmed: 24275163
Acta Histochem. 2017 Mar;119(2):99-112
pubmed: 27887793
Cancer Prev Res (Phila). 2015 Oct;8(10):879-87
pubmed: 25873370
Transl Lung Cancer Res. 2016 Jun;5(3):288-300
pubmed: 27413711
Int J Immunopathol Pharmacol. 2013 Jan-Mar;26(1):117-25
pubmed: 23527714
Chem Biol Interact. 1989;69(4):293-317
pubmed: 2659197
Asian Pac J Cancer Prev. 2013;14(8):4599-602
pubmed: 24083709