Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance.
MIC50
antibacterial resistance
antibiotics
ceftriaxone
gold nanoparticles
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
08 Nov 2021
08 Nov 2021
Historique:
received:
05
10
2021
revised:
03
11
2021
accepted:
05
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Ceftriaxone has been a part of therapeutic regime for combating some of the most aggressive bacterial infections in the last few decades. However, increasing bacterial resistance towards ceftriaxone and other third generation cephalosporin antibiotics has raised serious clinical concerns especially due to their misuse in the COVID-19 era. Advancement in nanotechnology has converted nano-therapeutic vision into a plausible reality with better targeting and reduced drug consumption. Thus, in the present study, gold nanoparticles (GNPs) were synthesized by using ceftriaxone antibiotic that acts as a reducing as well as capping agent. Ceftriaxone-loaded GNPs (CGNPs) were initially characterized by UV-visible spectroscopy, DLS, Zeta potential, Electron microscopy and FT-IR. However, a TEM micrograph showed a uniform size of 21 ± 1 nm for the synthesized CGNPs. Further, both (CGNPs) and pure ceftriaxone were examined for their efficacy against
Identifiants
pubmed: 34834310
pii: pharmaceutics13111896
doi: 10.3390/pharmaceutics13111896
pmc: PMC8622407
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : University of Hail
ID : BA-2026
Références
Cell Mol Life Sci. 2009 Sep;66(17):2873-96
pubmed: 19499185
Int Sch Res Notices. 2014 Aug 24;2014:278173
pubmed: 27355020
Nanoscale Res Lett. 2014 Feb 17;9(1):79
pubmed: 24533676
Saudi J Biol Sci. 2015 Jan;22(1):42-9
pubmed: 25561882
J Cell Biochem. 2017 Sep;118(9):2802-2808
pubmed: 28181300
Chem Phys Lipids. 2016 Oct;200:126-132
pubmed: 27697513
Appl Environ Microbiol. 1999 Sep;65(9):4094-8
pubmed: 10473421
Top Curr Chem (Cham). 2019 Dec 16;378(1):8
pubmed: 31840194
Adv Mater. 2009 Apr 20;21(31):3175-3180
pubmed: 20174478
Mater Sci Eng C Mater Biol Appl. 2012 Aug 1;32(6):1571-7
pubmed: 24364962
Adv Drug Deliv Rev. 2009 Jun 21;61(6):478-86
pubmed: 19389433
Molecules. 2016 Jun 27;21(7):
pubmed: 27355939
Chem Soc Rev. 2011 Jan;40(1):44-56
pubmed: 20818451
Nanoscale. 2017 Jan 5;9(2):812-822
pubmed: 27982150
Appl Environ Microbiol. 2007 Mar;73(6):1712-20
pubmed: 17261510
J Am Chem Soc. 2002 May 22;124(20):5811-21
pubmed: 12010056
Nanoscale Res Lett. 2018 Oct 25;13(1):339
pubmed: 30361809
Biotechnol Appl Biochem. 2010 Jan 25;55(1):29-35
pubmed: 19929854
Antimicrob Resist Infect Control. 2019 Feb 12;8:36
pubmed: 30805183
Nanotechnology. 2005 Oct;16(10):2346-53
pubmed: 20818017
Int J Nanomedicine. 2019 Sep 09;14:7281-7289
pubmed: 31686808
Nanotechnol Sci Appl. 2012 Sep 07;5:87-100
pubmed: 24198499
Antimicrob Agents Chemother. 1995 Nov;39(11):2516-9
pubmed: 8585736
Int J Nanomedicine. 2014 Mar 07;9:1231-42
pubmed: 24634584
Molecules. 2015 May 18;20(5):8856-74
pubmed: 25993417
Curr Opin Biotechnol. 2015 Dec;35:135-40
pubmed: 26277646
Nanomaterials (Basel). 2020 Nov 25;10(12):
pubmed: 33255714
J Infect Public Health. 2021 May;14(5):555-560
pubmed: 33848884
Langmuir. 2004 Mar 2;20(5):1909-14
pubmed: 15801462
Appl Environ Microbiol. 2012 Apr;78(8):2768-74
pubmed: 22286985
Trop Med Health. 2021 Jun 23;49(1):51
pubmed: 34162445
Bioconjug Chem. 2009 Dec;20(12):2247-53
pubmed: 19919059
Small. 2011 May 23;7(10):1322-37
pubmed: 21520409
Planta Med. 1998 Dec;64(8):711-3
pubmed: 9933989
Lasers Med Sci. 2008 Jul;23(3):217-28
pubmed: 17674122