miRNA Delivery by Nanosystems: State of the Art and Perspectives.
miRNA delivery
nanoparticles
non-viral vectors
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
09 Nov 2021
09 Nov 2021
Historique:
received:
26
09
2021
revised:
25
10
2021
accepted:
04
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
MicroRNAs (miRNAs) are short (~21-23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emerged as potential biopharmaceuticals candidates for the treatment of various diseases, including cancer, cardiovascular and metabolic diseases. However, in order to advance miRNAs therapeutics into clinical settings, their delivery remains a major challenge. Different types of vectors have been investigated to allow the delivery of miRNA in the diseased tissue. In particular, non-viral delivery systems have shown important advantages such as versatility, low cost, easy fabrication and low immunogenicity. Here, we present a general overview of the main types of non-viral vectors developed for miRNA delivery, with their advantages, limitations and future perspectives.
Identifiants
pubmed: 34834316
pii: pharmaceutics13111901
doi: 10.3390/pharmaceutics13111901
pmc: PMC8619868
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Council for Scientific and Technological Development
ID : 201245/2017-5
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