Spray-Dried Paracetamol/Polyvinylpyrrolidone Amorphous Solid Dispersions: Part I-Stability of Powders and Tablets.
amorphous solid dispersion
drug release
recrystallization
tablet
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
16 Nov 2021
16 Nov 2021
Historique:
received:
31
07
2021
revised:
03
11
2021
accepted:
11
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
The formulation of active pharmaceutical ingredients (APIs) in amorphous solid dispersions (ASDs) is a promising approach to improve the bioavailability of poorly soluble compounds. However, problems often arise in the production of tablets from ASDs regarding the compressibility and recrystallization of the API. In the present study, the preparation of spray-dried ASDs of paracetamol (PCM) and four different types of polyvinylpyrrolidone (PVP) and their further processing into tablets were investigated. The influence of PVP type on the glass transition temperature (T
Identifiants
pubmed: 34834353
pii: pharmaceutics13111938
doi: 10.3390/pharmaceutics13111938
pmc: PMC8621994
pii:
doi:
Types de publication
Journal Article
Langues
eng
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