Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis.
cognition
cognitive impairment
longitudinal
multiple sclerosis
neuroimaging
predictors
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
28 Oct 2021
28 Oct 2021
Historique:
received:
30
09
2021
revised:
22
10
2021
accepted:
26
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
(1) Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper features a longitudinal study with 212 patients who underwent several cognitive examinations at different time points. Dynamics of cognition were assessed using mixed-effects linear spline models. Machine learning techniques were used to identify which baseline demographic, clinical, and neuroimaging measures best predicted CI. (3) Results: In the first 5 years of MS, we detected an increase in the z-scores of global cognition, verbal memory, and information processing speed, which was followed by a decline in global cognition and memory (
Identifiants
pubmed: 34834459
pii: jpm11111107
doi: 10.3390/jpm11111107
pmc: PMC8624684
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI15/00587
Organisme : Instituto de Salud Carlos III
ID : PI15/00061
Organisme : Instituto de Salud Carlos III
ID : JR16/00006
Organisme : Instituto de Salud Carlos III
ID : PI18/01030
Organisme : Instituto de Salud Carlos III
ID : MV17/00021
Organisme : Instituto de Salud Carlos III
ID : PI17/01228
Organisme : Instituto de Salud Carlos III
ID : RD16/0015/0003
Organisme : Spanish Multiple Sclerosis Network
ID : RD16/0015/0002
Organisme : Spanish Multiple Sclerosis Network
ID : RD16/0015/0003
Organisme : Spanish Multiple Sclerosis Network
ID : RD12/0032/0002
Organisme : Spanish Multiple Sclerosis Network
ID : RD12/0060/01-02
Organisme : P-FIS contract
ID : FI19/00111
Organisme : Miguel Servet Research Contract
ID : CPII19/00009
Organisme : Instituto de Salud Carlos III
ID : PI19/00394
Références
Mult Scler. 2020 Sep;26(10):1247-1255
pubmed: 31233379
Neurol Sci. 2010 Nov;31(Suppl 2):S211-4
pubmed: 20640466
Lancet Neurol. 2008 Dec;7(12):1139-51
pubmed: 19007738
Neuroimage. 2020 Sep;218:116956
pubmed: 32470572
Neuroimage. 2017 Nov 1;161:149-170
pubmed: 28826946
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237
Lancet Neurol. 2015 Feb;14(2):183-93
pubmed: 25772897
Mult Scler. 2019 May;25(6):801-810
pubmed: 29683371
Neurology. 2018 Feb 6;90(6):278-288
pubmed: 29343470
J Neurol Neurosurg Psychiatry. 2014 Jan;85(1):67-75
pubmed: 23486991
Brain Behav. 2018 Jan 05;8(2):e00875
pubmed: 29484253
Mult Scler. 2018 Aug;24(9):1163-1173
pubmed: 28657480
Mult Scler. 2006 Apr;12(2):187-95
pubmed: 16629422
Mult Scler. 2020 Nov;26(13):1740-1751
pubmed: 31603042
J Clin Exp Neuropsychol. 2009 Nov;31(8):913-26
pubmed: 19330566
Neuropsychologia. 2015 Mar;69:39-49
pubmed: 25619848
PLoS Comput Biol. 2017 Feb 23;13(2):e1005350
pubmed: 28231282
Front Neurol. 2018 Mar 12;9:132
pubmed: 29593633
Radiology. 2018 Aug;288(2):544-551
pubmed: 29786489
Front Neurol. 2021 Feb 05;11:623914
pubmed: 33613423
Neuroimage Clin. 2016 Dec 05;13:288-296
pubmed: 28050344
Appl Neuropsychol Adult. 2021 Mar-Apr;28(2):210-219
pubmed: 31204507
Mult Scler. 2021 May 6;:13524585211011390
pubmed: 33951975
Neuroimage. 2009 Aug 15;47(2):773-8
pubmed: 19393745
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
JAMA Neurol. 2021 Apr 1;78(4):414-425
pubmed: 33393981
BMC Res Notes. 2014 Dec 15;7:910
pubmed: 25512202
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Mult Scler. 2013 Sep;19(10):1290-6
pubmed: 23459568
PLoS One. 2013 Aug 01;8(8):e71058
pubmed: 23936485
Neurology. 1991 May;41(5):685-91
pubmed: 2027484
Nat Rev Neurosci. 2018 Oct;19(10):599-609
pubmed: 30158590
Neuroimage. 2008 Sep 1;42(3):1237-43
pubmed: 18585467
Front Neurol. 2020 Oct 30;11:581700
pubmed: 33193039