RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
RNA binding proteins
RNA sensing
host vs. pathogen
innate immunity
post-transcriptional gene regulation
viral infection
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
28 10 2021
28 10 2021
Historique:
received:
27
09
2021
revised:
22
10
2021
accepted:
23
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
2
2022
Statut:
epublish
Résumé
As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest events between viral RNA and the RBPs that act upon them. These discoveries have sparked a re-evaluation of current paradigms surrounding RBPs and post-transcriptional gene regulation. Here, we highlight questions that have bloomed from the implementation of these novel approaches. Canonical RBPs can impact the fates of both cellular and viral RNA during infection, sometimes in conflicting ways. Noncanonical RBPs, some of which were first characterized via interactions with viral RNA, may encompass physiological roles beyond viral pathogenesis. We discuss how these RBPs might discriminate between an RNA of either cellular or viral origin and thus exert either pro- or antiviral effects-which is a particular challenge as viruses contain mechanisms to mimic molecular features of cellular RNA.
Identifiants
pubmed: 34834978
pii: v13112172
doi: 10.3390/v13112172
pmc: PMC8625426
pii:
doi:
Substances chimiques
RNA, Messenger
0
RNA, Viral
0
RNA-Binding Proteins
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM119569
Pays : United States
Organisme : NIGMS NIH HHS
ID : 5T32GM065086-14
Pays : United States
Organisme : NIGMS NIH HHS
ID : 5T32GM008554
Pays : United States
Organisme : NIGMS NIH HHS
ID : 1R35GM119569-01
Pays : United States
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