The Progestin Medroxyprogesterone Acetate Affects HIV-1 Production in Human Lymphoid Tissue Explants in a Dose-Dependent and Glucocorticoid-like Fashion.
DMPA
HIV-1
cytokines
glucocorticoids
hormonal contraception
lymphoid tissue
progesterone
sex hormones
tissue explants
tonsils
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
18 11 2021
18 11 2021
Historique:
received:
28
09
2021
revised:
31
10
2021
accepted:
12
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
2
2022
Statut:
epublish
Résumé
The association between the use of the injectable contraceptive depot medroxyprogesterone acetate and HIV-1 susceptibility has been addressed mainly in respect to the changes occurring in the female genital mucosa and blood. However, one of the main sites of HIV-1 pathogenesis is lymphoid organs. To investigate the immunoregulatory effect of medroxyprogesterone acetate (MPA) at this site, human tonsillar tissue explants were infected ex vivo with either a CCR5 (BaL) or CXCR4 (LAI) HIV-1 variant and the release of p24
Identifiants
pubmed: 34835109
pii: v13112303
doi: 10.3390/v13112303
pmc: PMC8621851
pii:
doi:
Substances chimiques
Contraceptive Agents, Hormonal
0
Medroxyprogesterone Acetate
C2QI4IOI2G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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