Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages.
G2 arrest
HIP1
HIV-1
Vpr
macrophage
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
19 11 2021
19 11 2021
Historique:
received:
08
10
2021
revised:
02
11
2021
accepted:
17
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
2
2022
Statut:
epublish
Résumé
Human immunodeficiency virus type 1 (HIV-1) modulates the host cell cycle. The HIV-1 accessory protein Vpr arrests the cell cycle at the G2 phase in dividing cells, and the ability of Vpr to induce G2 arrest is well conserved among primate lentiviruses. Additionally, Vpr-mediated G2 arrest likely correlates with enhanced HIV-1 infection in monocyte-derived macrophages. Here, we screened small-interfering RNA to reveal candidates that suppress Vpr-induced G2 arrest and identified Huntingtin-interacting protein 1 (HIP1) required for efficient G2 arrest. Interestingly, HIP1 was not essential for Vpr-induced DNA double-strand breaks, which are required for activation of the DNA-damage checkpoint and G2 arrest. Furthermore, HIP1 knockdown suppressed HIV-1 infection in monocyte-derived macrophages. This study identifies HIP1 as a factor promoting Vpr-induced G2 arrest and HIV-1 infection in macrophages.
Identifiants
pubmed: 34835114
pii: v13112308
doi: 10.3390/v13112308
pmc: PMC8624357
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
HIP1 protein, human
0
RNA, Small Interfering
0
vpr Gene Products, Human Immunodeficiency Virus
0
vpr protein, Human immunodeficiency virus 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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