Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine.
COVID-19
Roche Anti-SARS-CoV-2-S
immune response
mRNA vaccine
serological test
vaccination
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
received:
08
10
2021
revised:
05
11
2021
accepted:
17
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Studies reporting the long-term humoral response after receiving the BNT162b2 COVID-19 vaccine are important to drive future vaccination strategies. Yet, available literature is scarce. Covidiagnostix is a multicenter study designed to assess the antibody response in >1000 healthcare professionals (HCPs) who received the BNT162b2 vaccine. Serum was tested at time-0 (T Six months post-vaccination HCPs showed an antibody titer decrease of approximately 70%, yet, the titer was still one order of magnitude higher than that of seropositive individuals before vaccination. We identified 12 post-vaccination infected HCPs. None showed severe symptoms. Interestingly, most of them showed titers at T Vaccination induces a humoral response which is well detectable even six months post-vaccination. Vaccination prevents severe COVID-19 cases, yet post-vaccination infection is possible even in the presence of a high anti-S serum antibody titer.
Sections du résumé
BACKGROUND
BACKGROUND
Studies reporting the long-term humoral response after receiving the BNT162b2 COVID-19 vaccine are important to drive future vaccination strategies. Yet, available literature is scarce. Covidiagnostix is a multicenter study designed to assess the antibody response in >1000 healthcare professionals (HCPs) who received the BNT162b2 vaccine.
METHODS
METHODS
Serum was tested at time-0 (T
RESULTS
RESULTS
Six months post-vaccination HCPs showed an antibody titer decrease of approximately 70%, yet, the titer was still one order of magnitude higher than that of seropositive individuals before vaccination. We identified 12 post-vaccination infected HCPs. None showed severe symptoms. Interestingly, most of them showed titers at T
CONCLUSION
CONCLUSIONS
Vaccination induces a humoral response which is well detectable even six months post-vaccination. Vaccination prevents severe COVID-19 cases, yet post-vaccination infection is possible even in the presence of a high anti-S serum antibody titer.
Identifiants
pubmed: 34835288
pii: vaccines9111357
doi: 10.3390/vaccines9111357
pmc: PMC8620373
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : COVID-2020-12371619
Références
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
JAMA. 2021 Apr 13;325(14):1467-1469
pubmed: 33646292
Lancet. 2021 Mar 20;397(10279):1057-1058
pubmed: 33640038
Vaccines (Basel). 2021 May 18;9(5):
pubmed: 34070196
N Engl J Med. 2021 Jun 10;384(23):2259-2261
pubmed: 33822494
J Med Virol. 2021 Apr;93(4):2160-2167
pubmed: 33064340
Vaccines (Basel). 2021 Aug 16;9(8):
pubmed: 34452038
N Engl J Med. 2021 Apr 8;384(14):1372-1374
pubmed: 33691060
Lancet. 2021 Mar 27;397(10280):1178-1181
pubmed: 33640037
Clin Chem Lab Med. 2021 Oct 07;59(12):2019-2026
pubmed: 34614550
Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7348-E7357
pubmed: 28807998
Clin Chem. 2020 Nov 1;66(11):1405-1413
pubmed: 32777031
Vaccine. 2021 Jul 13;39(31):4256-4260
pubmed: 34147292
Semin Immunol. 2018 Dec;40:83-94
pubmed: 30501873
Emerg Microbes Infect. 2021 Dec;10(1):1495-1498
pubmed: 34232116
Int J Technol Assess Health Care. 2021 Sep 22;37(1):e87
pubmed: 34548114
Int J Infect Dis. 2021 Feb;103:590-596
pubmed: 33310108
N Engl J Med. 2021 Mar 8;384(15):1466-1468
pubmed: 33684280
Nature. 2020 Oct;586(7830):589-593
pubmed: 32785213
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Hum Vaccin Immunother. 2016;12(1):239-43
pubmed: 26836329
Viruses. 2021 Jul 31;13(8):
pubmed: 34452380
Clin Chem. 2020 Aug 1;66(8):1104-1106
pubmed: 32484887
Clin Chim Acta. 2021 Aug;519:60-63
pubmed: 33857476
Forensic Sci Int. 2018 Jul;288:211-217
pubmed: 29775921
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Stat Methods Med Res. 2017 Jun;26(3):1373-1388
pubmed: 25847911
Clin Chim Acta. 2021 Nov;522:144-151
pubmed: 34425105
Clin Chem Lab Med. 2020 Jun 25;58(7):1095-1099
pubmed: 32301746