Bhalin, an Essential Cytoskeleton-Associated Protein of
cytoskeleton
endocytosis
flagellar pocket
flagellar pocket collar
hook complex
protozoan
trypanosoma
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
11 Nov 2021
11 Nov 2021
Historique:
received:
08
10
2021
revised:
26
10
2021
accepted:
04
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
In most trypanosomes, endo and exocytosis only occur at a unique organelle called the flagellar pocket (FP) and the flagellum exits the cell via the FP. Investigations of essential cytoskeleton-associated structures located at this site have revealed a number of essential proteins. The protein Here, we show that a newly characterised protein, BHALIN (BILBO1 Hook Associated LINker protein), is localised to both the FPC and HC and has a Our results demonstrate the essential role of a newly characterised hook complex protein, BHALIN, that influences flagellar pocket organisation and function in bloodstream form
Sections du résumé
BACKGROUND
BACKGROUND
In most trypanosomes, endo and exocytosis only occur at a unique organelle called the flagellar pocket (FP) and the flagellum exits the cell via the FP. Investigations of essential cytoskeleton-associated structures located at this site have revealed a number of essential proteins. The protein
METHODOLOGY/PRINCIPAL FINDINGS
RESULTS
Here, we show that a newly characterised protein, BHALIN (BILBO1 Hook Associated LINker protein), is localised to both the FPC and HC and has a
CONCLUSIONS/SIGNIFICANCE
CONCLUSIONS
Our results demonstrate the essential role of a newly characterised hook complex protein, BHALIN, that influences flagellar pocket organisation and function in bloodstream form
Identifiants
pubmed: 34835460
pii: microorganisms9112334
doi: 10.3390/microorganisms9112334
pmc: PMC8623173
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-11-LABX-0024
Organisme : Agence Nationale de la Recherche
ID : ANR-20-CE91-0003
Organisme : Agence Nationale de la Recherche
ID : ANR-10-INBS-04
Organisme : Centre National de la Recherche Scientifique
ID : CNRS UMR5234
Organisme : University of Bordeaux
ID : UMR5234
Organisme : MESRI
ID : PhD fellowship
Références
Open Biol. 2012 Feb;2(2):110037
pubmed: 22645659
Mol Biochem Parasitol. 2000 Dec;111(2):283-97
pubmed: 11163437
Mol Microbiol. 2004 Aug;53(3):735-44
pubmed: 15255888
Curr Med Chem. 2010;17(15):1594-617
pubmed: 20166934
J Cell Sci. 1995 Nov;108 ( Pt 11):3611-21
pubmed: 8586672
PLoS One. 2012;7(2):e31344
pubmed: 22355359
J Cell Sci. 2019 Jul 15;132(14):
pubmed: 31217284
Mol Biochem Parasitol. 2009 Oct;167(2):95-103
pubmed: 19445968
J Cell Sci. 2004 Mar 1;117(Pt 7):1105-15
pubmed: 14996937
Nature. 2006 Mar 9;440(7081):224-7
pubmed: 16525475
Mol Biochem Parasitol. 2005 Jan;139(1):75-82
pubmed: 15610821
Front Immunol. 2018 Oct 02;9:2253
pubmed: 30333827
PLoS Biol. 2008 May 6;6(5):e105
pubmed: 18462016
J Cell Sci. 2006 May 1;119(Pt 9):1852-63
pubmed: 16608878
Front Cell Infect Microbiol. 2013 Nov 13;3:71
pubmed: 24312899
J Biol Chem. 2020 Sep 11;295(37):12962-12974
pubmed: 32675283
Mol Biochem Parasitol. 2011 Jan;175(1):91-4
pubmed: 20851719
J Cell Sci. 2016 Jun 1;129(11):2285
pubmed: 27252358
EMBO J. 2004 Feb 25;23(4):780-9
pubmed: 14963487
J Parasitol. 1989 Dec;75(6):985-9
pubmed: 2614608
Biophys J. 2004 Dec;87(6):4259-70
pubmed: 15361408
PLoS Pathog. 2021 Aug 2;17(8):e1009329
pubmed: 34339455
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17425-30
pubmed: 19805090
Cells. 2016 Mar 02;5(1):
pubmed: 26950156
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W465-9
pubmed: 18424797
Mol Biochem Parasitol. 1999 Mar 15;99(1):89-101
pubmed: 10215027
PLoS Pathog. 2017 Nov 1;13(11):e1006710
pubmed: 29091964
J Cell Biol. 2008 May 5;181(3):431-8
pubmed: 18443217
Trends Parasitol. 2021 Apr;37(4):317-329
pubmed: 33308952
Mol Biochem Parasitol. 1996 May;77(2):235-9
pubmed: 8813669
J Biol Chem. 2014 Aug 22;289(34):23870-81
pubmed: 25031322
J Cell Sci. 2009 Apr 15;122(Pt 8):1081-90
pubmed: 19299460
Nature. 1986 Feb 6-12;319(6053):511-4
pubmed: 3456080
J Cell Sci. 2017 Nov 15;130(22):3918-3932
pubmed: 28993462
PLoS One. 2015 Sep 11;10(9):e0137652
pubmed: 26360249
Science. 2005 Jul 15;309(5733):416-22
pubmed: 16020726
PLoS Pathog. 2010 Aug 19;6(8):e1001050
pubmed: 20808899
Eukaryot Cell. 2013 Feb;12(2):356-67
pubmed: 23264645
J Biol Chem. 2014 Feb 7;289(6):3724-35
pubmed: 24362019
J Eukaryot Microbiol. 1999 Mar-Apr;46(2):105-9
pubmed: 10361731
Science. 2005 Nov 18;310(5751):1196-8
pubmed: 16254149
J Cell Sci. 1989 Jul;93 ( Pt 3):491-500
pubmed: 2606940
Z Parasitenkd. 1978 Jun 30;55(3):181-7
pubmed: 695819
Mol Biol Cell. 2003 May;14(5):2029-40
pubmed: 12802073
Mol Microbiol. 2018 Feb;107(3):344-362
pubmed: 29178204
Eur J Biochem. 2003 Aug;270(15):3205-13
pubmed: 12869196
PLoS Pathog. 2015 Mar 30;11(3):e1004654
pubmed: 25822645
Eukaryot Cell. 2015 Nov;14(11):1081-93
pubmed: 26318396
Methods Mol Biol. 2018;1757:69-113
pubmed: 29761457
Open Biol. 2015 Jan;5(1):140197
pubmed: 25567099
J Cell Sci. 2008 Sep 15;121(Pt 18):3062-70
pubmed: 18768932
J Mol Biol. 1990 Oct 5;215(3):403-10
pubmed: 2231712
BMC Evol Biol. 2010 Jan 12;10:8
pubmed: 20067610
PLoS One. 2010 Mar 15;5(3):e9660
pubmed: 20300570
Microbiol Resour Announc. 2019 Feb 28;8(9):
pubmed: 30834384
Commun Integr Biol. 2016 Jan 19;8(6):e1082691
pubmed: 27064836
EMBO J. 2003 Oct 1;22(19):4991-5002
pubmed: 14517238