Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents.
Adult
Biomarkers
/ blood
COVID-19
/ blood
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor
/ genetics
Cholestanetriol 26-Monooxygenase
/ genetics
Cytochrome P450 Family 2
/ genetics
Female
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Calcitriol
/ genetics
Severity of Illness Index
United Arab Emirates
Vitamin D
/ analogs & derivatives
COVID-19
UAE
genotypes
metabolism
polymorphism
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
20 Oct 2021
20 Oct 2021
Historique:
received:
30
09
2021
revised:
15
10
2021
accepted:
15
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (
Identifiants
pubmed: 34835935
pii: nu13113680
doi: 10.3390/nu13113680
pmc: PMC8625365
pii:
doi:
Substances chimiques
Biomarkers
0
Receptors, Calcitriol
0
VDR protein, human
0
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Cytochrome P450 Family 2
EC 1.14.14.1
CYP2R1 protein, human
EC 1.14.14.24
Cholestanetriol 26-Monooxygenase
EC 1.14.15.15
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor
EC 6.3.5.-
NADSYN1 protein, human
EC 6.3.5.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Zayed University
ID : 004
Organisme : Khalifa University of Science and Technology
ID : COVID19004
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