Nitric oxide releasing nanomatrix gel treatment inhibits venous intimal hyperplasia and improves vascular remodeling in a rodent arteriovenous fistula.
And nitric oxide releasing nanomatrix gel
Arteriovenous fistula
Endothelial nitric oxide synthase
Intimal hyperplasia
Nitric oxide
Vascular remodeling
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
02
11
2020
revised:
08
11
2021
accepted:
10
11
2021
pubmed:
28
11
2021
medline:
15
3
2022
entrez:
27
11
2021
Statut:
ppublish
Résumé
Vascular access is the lifeline for hemodialysis patients and the single most important component of the hemodialysis procedure. Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis patients, but nearly 60% of AVFs created fail to successfully mature due to early intimal hyperplasia development and poor outward remodeling. There are currently no therapies available to prevent AVF maturation failure. First, we showed the important regulatory role of nitric oxide (NO) on AVF development by demonstrating that intimal hyperplasia development was reduced in an overexpressed endothelial nitric oxide synthase (NOS3) mouse AVF model. This supported the rationale for the potential application of NO to the AVF. Thus, we developed a self-assembled NO releasing nanomatrix gel and applied it perivascularly at the arteriovenous anastomosis immediately following rat AVF creation to investigate its therapeutic effect on AVF development. We demonstrated that the NO releasing nanomatrix gel inhibited intimal hyperplasia formation (more than 70% reduction), as well as improved vascular outward remodeling (increased vein diameter) and hemodynamic adaptation (lower wall shear stress approaching the preoperative level and less vorticity). Therefore, direct application of the NO releasing nanomatrix gel to the AVF anastomosis immediately following AVF creation may enhance AVF development, thereby providing long-term and durable vascular access for hemodialysis.
Identifiants
pubmed: 34836683
pii: S0142-9612(21)00611-6
doi: 10.1016/j.biomaterials.2021.121254
pmc: PMC8724452
mid: NIHMS1759572
pii:
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
121254Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK121227
Pays : United States
Organisme : NIDDK NIH HHS
ID : R44 DK109789
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK129299
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153244
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013148
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079337
Pays : United States
Organisme : NIDDK NIH HHS
ID : R43 DK109789
Pays : United States
Organisme : BLRD VA
ID : I01 BX003387
Pays : United States
Organisme : BLRD VA
ID : I01 BX004133
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA042014
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139692
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125391
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100505
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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