Evaluation of Hepatoprotective effects of different doses of Lyophilized Beetroot powder in albino rabbits.


Journal

Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356

Informations de publication

Date de publication:
Sep 2021
Historique:
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 26 2 2022
Statut: ppublish

Résumé

Beta vulgaris L. is a vegetable most commonly consumed in salads and has been shown to possess multiple benefits. This research was carried out to observe the effects of Beta vulgaris powder at different doses orally in albino rabbits on liver biochemical parameters and coagulation. The study was carried out on albino rabbits which were divided into three groups designated as Group I (administered distilled water) Group II and III (administered beetroot powder at 500mg/kg and 1000mg/kg dose respectively) orally for 2 month duration. The sample was withdrawn at day 0, 30th and 60th day through cardiac puncture. The results showed that both doses of Beta vulgaris were considered safe for use as all the liver parameters were significantly decreased compared to control. Among both doses 500mg/kg dose was considered safer as it reduced the parameters significantly compared to 1000mg/kg dose. Blood coagulation factors at both the doses showed significant increase which was in reference range. Beta vulgaris is a highly beneficial dietary product with ample amount of flavonoids and anti-oxidant agents which might help in improving the liver function and also play a role in coagulation by increasing both fibrinogen levels and prothrombin time.

Identifiants

pubmed: 34836860

Substances chimiques

Powders 0
Protective Agents 0
Fibrinogen 9001-32-5
Aspartate Aminotransferases EC 2.6.1.1
Alanine Transaminase EC 2.6.1.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1917-1922

Auteurs

Sana Sarfaraz (S)

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Rahela Ikram (R)

Faculty of Pharmacy, Salim Habib University, Karachi, Pakistan.

Rabia Munawwar (R)

Faculty of Pharmacy, Jinnah Sindh Medical University Karachi, Pakistan.

Sakina Fatima (S)

Faculty of Pharmacy, Jinnah Sindh Medical University Karachi, Pakistan.

Humera Anser (H)

Faculty of Pharmacy, Jinnah Sindh Medical University Karachi, Pakistan.

Mahwish Fatima (M)

Indus Hospital, Karachi, Pakistan.

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Classifications MeSH