Wide-field mosaics of the corneal subbasal nerve plexus in Parkinson's disease using in vivo confocal microscopy.
Journal
Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192
Informations de publication
Date de publication:
26 11 2021
26 11 2021
Historique:
received:
07
05
2021
accepted:
28
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
In vivo confocal microscopy (IVCM) is a non-invasive imaging technique facilitating real-time acquisition of images from the live cornea and its layers with high resolution (1-2 µm) and high magnification (600 to 800-fold). IVCM is extensively used to examine the cornea at a cellular level, including the subbasal nerve plexus (SBNP). IVCM of the cornea has thus gained intense interest for probing ophthalmic and systemic diseases affecting peripheral nerves. One of the main drawbacks, however, is the small field of view of IVCM, preventing an overview of SBNP architecture and necessitating subjective image sampling of small areas of the SBNP for analysis. Here, we provide a high-quality dataset of the corneal SBNP reconstructed by automated mosaicking, with an average mosaic image size corresponding to 48 individual IVCM fields of view. The mosaic dataset represents a group of 42 individuals with Parkinson's disease (PD) with and without concurrent restless leg syndrome. Additionally, mosaics from a control group (n = 13) without PD are also provided, along with clinical data for all included participants.
Identifiants
pubmed: 34836991
doi: 10.1038/s41597-021-01087-3
pii: 10.1038/s41597-021-01087-3
pmc: PMC8626466
doi:
Types de publication
Dataset
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
306Informations de copyright
© 2021. The Author(s).
Références
Feigin, V. L. et al. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. Neurology 16, 877–897 (2017).
doi: 10.1016/S1474-4422(17)30299-5
Postuma, R. B. et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30, 1591–1601 (2015).
pubmed: 26474316
doi: 10.1002/mds.26424
Toth, C. et al. Levodopa, methylmalonic acid, and neuropathy in idiopathic Parkinson disease. Annals of neurology 68, 28–36 (2010).
pubmed: 20582991
doi: 10.1002/ana.22021
Doppler, K. et al. Cutaneous neuropathy in Parkinson’s disease: a window into brain pathology. Acta neuropathologica 128, 99–109 (2014).
pubmed: 24788821
pmcid: 4059960
doi: 10.1007/s00401-014-1284-0
Gómez-Esteban, J. C. et al. Restless legs syndrome in Parkinson’s disease. Movement disorders: official journal of the Movement Disorder Society 22, 1912–1916 (2007).
doi: 10.1002/mds.21624
Möller, J. C., Unger, M., Stiasny-Kolster, K. & Oertel, W. H. Restless Legs Syndrome (RLS) and Parkinson’s disease (PD)-related disorders or different entities? Journal of the neurological sciences 289, 135–137 (2010).
pubmed: 19755200
doi: 10.1016/j.jns.2009.08.035
Angelini, M., Negrotti, A., Marchesi, E., Bonavina, G. & Calzetti, S. A study of the prevalence of restless legs syndrome in previously untreated Parkinson’s disease patients: absence of co-morbid association. Journal of the neurological sciences 310, 286–288 (2011).
pubmed: 21889169
doi: 10.1016/j.jns.2011.08.012
Rijsman, R. M., Schoolderman, L. F., Rundervoort, R. S. & Louter, M. Restless legs syndrome in Parkinson’s disease. Parkinsonism & related disorders 20(Suppl 1), S5–9 (2014).
doi: 10.1016/S1353-8020(13)70004-X
Malik, R. A. et al. Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia 46, 683–688 (2003).
pubmed: 12739016
doi: 10.1007/s00125-003-1086-8
Messmer, E. M., Schmid-Tannwald, C., Zapp, D. & Kampik, A. In vivo confocal microscopy of corneal small fiber damage in diabetes mellitus. Graefe’s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 248, 1307–1312 (2010).
pubmed: 20490534
doi: 10.1007/s00417-010-1396-8
Perkins, B. A. et al. Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study. Diabetologia 61, 1856–1861 (2018).
pubmed: 29869146
pmcid: 6061173
doi: 10.1007/s00125-018-4653-8
Jiang, M. S., Yuan, Y., Gu, Z. X. & Zhuang, S. L. Corneal confocal microscopy for assessment of diabetic peripheral neuropathy: a meta-analysis. The British journal of ophthalmology 100, 9–14 (2016).
pubmed: 25677672
doi: 10.1136/bjophthalmol-2014-306038
Tavakoli, M. et al. Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes care 33, 1792–1797 (2010).
pubmed: 20435796
pmcid: 2909064
doi: 10.2337/dc10-0253
Petropoulos, I. N. et al. Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. Diabetes Care 36, 3646–3651 (2013).
pubmed: 23877983
pmcid: 3816900
doi: 10.2337/dc13-0193
Petropoulos, I. N. et al. Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Investigative ophthalmology & visual science 55, 2071–2078 (2014).
doi: 10.1167/iovs.13-13787
Lagali, N. S. et al. Reduced Corneal Nerve Fiber Density in Type 2 Diabetes by Wide-Area Mosaic Analysis. Invest Ophthalmol Vis Sci 58, 6318–6327 (2017).
pubmed: 29242906
doi: 10.1167/iovs.17-22257
Ferdousi, M. et al. Diabetic Neuropathy Is Characterized by Progressive Corneal Nerve Fiber Loss in the Central and Inferior Whorl Regions. Investigative ophthalmology & visual science 61, 48 (2020).
doi: 10.1167/iovs.61.3.48
Muller, L. J., Pels, L. & Vrensen, G. F. Ultrastructural organization of human corneal nerves. Investigative ophthalmology & visual science 37, 476–488 (1996).
Oliveira-Soto, L. & Efron, N. Morphology of corneal nerves using confocal microscopy. Cornea 20, 374–384 (2001).
pubmed: 11333324
doi: 10.1097/00003226-200105000-00008
Müller, L. J., Marfurt, C. F., Kruse, F. & Tervo, T. M. Corneal nerves: structure, contents and function. Exp. Eye Res. 76, 521–542 (2003).
pubmed: 12697417
doi: 10.1016/S0014-4835(03)00050-2
Eghrari, A. O., Riazuddin, S. A. & Gottsch, J. D. Overview of the Cornea: Structure, Function, and Development. Progress in molecular biology and translational science 134, 7–23 (2015).
pubmed: 26310146
doi: 10.1016/bs.pmbts.2015.04.001
Oliveira-Soto, L. & Efron, N. Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy. Ophthalmic & physiological optics: the journal of the British College of Ophthalmic Opticians (Optometrists) 23, 163–174 (2003).
doi: 10.1046/j.1475-1313.2003.00106.x
Jalbert, I., Stapleton, F., Papas, E., Sweeney, D. F. & Coroneo, M. In vivo confocal microscopy of the human cornea. The British journal of ophthalmology 87, 225–236 (2003).
pubmed: 12543757
pmcid: 1771516
doi: 10.1136/bjo.87.2.225
Stachs, O., Guthoff, R. F. & Aumann, S. In Vivo Confocal Scanning Laser Microscopy. in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics (ed. Bille, J. F.) 263–284 (Springer International Publishing, Cham, 2019).
Tavakoli, M., Petropoulos, I. N. & Malik, R. A. Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot. Journal of diabetes science and technology 7, 1179–1189 (2013).
pubmed: 24124944
pmcid: 3876361
doi: 10.1177/193229681300700509
Lagali, N. et al. Focused Tortuosity Definitions Based on Expert Clinical Assessment of Corneal Subbasal Nerves. Investigative ophthalmology & visual science 56, 5102–5109 (2015).
doi: 10.1167/iovs.15-17284
Kass-Iliyya, L. et al. Small fiber neuropathy in Parkinson’s disease: A clinical, pathological and corneal confocal microscopy study. Parkinsonism & related disorders 21, 1454–1460 (2015).
doi: 10.1016/j.parkreldis.2015.10.019
Podgorny, P. J., Suchowersky, O., Romanchuk, K. G. & Feasby, T. E. Evidence for small fiber neuropathy in early Parkinson’s disease. Parkinsonism & related disorders 28, 94–99 (2016).
doi: 10.1016/j.parkreldis.2016.04.033
Misra, S. L., Kersten, H. M., Roxburgh, R. H., Danesh-Meyer, H. V. & McGhee, C. N. Corneal nerve microstructure in Parkinson’s disease. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia 39, 53–58 (2017).
doi: 10.1016/j.jocn.2017.02.033
Andréasson, M. et al. Parkinson’s disease with restless legs syndrome-an in vivo corneal confocal microscopy study. NPJ Parkinsons Dis 7, 4 (2021).
pubmed: 33402694
pmcid: 7785738
doi: 10.1038/s41531-020-00148-5
Lagali, N. S. et al. Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations. Sci Data 5, 180075 (2018).
pubmed: 29688226
pmcid: 5914299
doi: 10.1038/sdata.2018.75
Whitton, P. S. Inflammation as a causative factor in the aetiology of Parkinson’s disease. British journal of pharmacology 150, 963–976 (2007).
pubmed: 17339843
pmcid: 2013918
doi: 10.1038/sj.bjp.0707167
Tansey, M. G. & Goldberg, M. S. Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention. Neurobiology of disease 37, 510–518 (2010).
pubmed: 19913097
doi: 10.1016/j.nbd.2009.11.004
De Lella Ezcurra, A. L., Chertoff, M., Ferrari, C., Graciarena, M. & Pitossi, F. Chronic expression of low levels of tumor necrosis factor-alpha in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation. Neurobiology of disease 37, 630–640 (2010).
pubmed: 19969084
doi: 10.1016/j.nbd.2009.11.018
Lagali, N. S. et al. Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 9. Sci Rep 8, 14248 (2018).
pubmed: 30250206
pmcid: 6155153
doi: 10.1038/s41598-018-32410-5
Allen, R. P. et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med 15, 860–873 (2014).
pubmed: 25023924
doi: 10.1016/j.sleep.2014.03.025
Goetz, C. G. et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord 19, 1020–1028 (2004).
pubmed: 15372591
doi: 10.1002/mds.20213
Hoehn, M. M. & Yahr, M. D. Parkinsonism: onset, progression and mortality. Neurology 17, 427–442 (1967).
pubmed: 6067254
doi: 10.1212/WNL.17.5.427
Singleton, J. R. et al. The Utah Early Neuropathy Scale: a sensitive clinical scale for early sensory predominant neuropathy. J Peripher Nerv Syst 13, 218–227 (2008).
pubmed: 18844788
doi: 10.1111/j.1529-8027.2008.00180.x
Walters, A. S. et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 4, 121–132 (2003).
pubmed: 14592342
doi: 10.1016/S1389-9457(02)00258-7
De Cock, V. C. et al. Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson’s disease. Movement disorders: official journal of the Movement Disorder Society 27, 743–749 (2012).
doi: 10.1002/mds.24969
Michaud, M., Lavigne, G., Desautels, A., Poirier, G. & Montplaisir, J. Effects of immobility on sensory and motor symptoms of restless legs syndrome. Movement disorders: official journal of the Movement Disorder Society 17, 112–115 (2002).
doi: 10.1002/mds.10004
Bartschat, A. et al. Fuzzy tissue detection for real-time focal control in corneal confocal microscopy. at - Automatisierungstechnik 67, 879–888 (2019).
doi: 10.1515/auto-2019-0034
Foroosh, H., Zerubia, J. B. & Berthod, M. Extension of phase correlation to subpixel registration. IEEE transactions on image processing: a publication of the IEEE Signal Processing Society 11, 188–200 (2002).
doi: 10.1109/83.988953
Allgeier, S. et al. Elastische Registrierung von in-vivo-CLSM-Aufnahmen der Kornea. in Bildverarbeitung für die Medizin 2011: Algorithmen - Systeme - Anwendungen Proceedings des Workshops vom 20-22 März 2011 in Lübeck (eds. Handels, H., Ehrhardt, J., Deserno, T. M., Meinzer, H.-P. & Tolxdorff, T.) 149–153 (Springer Berlin Heidelberg, Berlin, Heidelberg, 2011).
Guimaraes, P., Wigdahl, J. & Ruggeri, A. A Fast and Efficient Technique for the Automatic Tracing of Corneal Nerves in Confocal Microscopy. Transl Vis Sci Technol 5, 7 (2016).
pubmed: 27730007
pmcid: 5054765
doi: 10.1167/tvst.5.5.7
Scarpa, F., Grisan, E. & Ruggeri, A. Automatic recognition of corneal nerve structures in images from confocal microscopy. Investigative ophthalmology & visual science 49, 4801–4807 (2008).
doi: 10.1167/iovs.08-2061
Dijkstra, E. W. A note on two problems in connexion with graphs. Numerische Mathematik 1, 269–271 (1959).
doi: 10.1007/BF01386390
Patel, D. V. & McGhee, C. N. Mapping of the normal human corneal sub-Basal nerve plexus by in vivo laser scanning confocal microscopy. Invest. Ophthalmol. Vis. Sci. 46, 4485–4488 (2005).
pubmed: 16303938
doi: 10.1167/iovs.05-0794
Utsunomiya, T. et al. Imaging of the Corneal Subbasal Whorl-like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients With Diabetes. Invest. Ophthalmol. Vis. Sci. 56, 5417–5423 (2015).
pubmed: 26284545
doi: 10.1167/iovs.15-16609
Pritchard, N. et al. Utility of Assessing Nerve Morphology in Central Cornea Versus Whorl Area for Diagnosing Diabetic Peripheral Neuropathy. Cornea 34, 756–761 (2015).
pubmed: 25909237
doi: 10.1097/ICO.0000000000000447
Badian, R. A. et al. Wide-field mosaic dataset of the corneal subbasal nerve plexus in Parkinson’s disease using in vivo confocal microscopy. figshare https://doi.org/10.6084/m6089.figshare.14481249 (2021).
Bland, J. M. & Altman, D. G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet (London, England) 1, 307–310 (1986).
doi: 10.1016/S0140-6736(86)90837-8