A SARS-CoV-2 antigen rapid diagnostic test for resource limited settings.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 11 2021
26 11 2021
Historique:
received:
30
06
2021
accepted:
10
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 disease. RT-qPCR has been the primary method of diagnosis; however, the required infrastructure is lacking in many developing countries and the virus has remained a global challenge. More inexpensive and immediate test methods are required to facilitate local, regional, and national management strategies to re-open world economies. Here we have developed a SARS-CoV-2 antigen test in an inexpensive lateral flow format to generate a chromatographic result identifying the presence of the SARS-CoV-2 antigen, and thus an active infection, within a patient anterior nares swab sample. Our 15-min test requires no equipment or laboratory infrastructure to administer with a limit of detection of 2.0 × 10
Identifiants
pubmed: 34837001
doi: 10.1038/s41598-021-02128-y
pii: 10.1038/s41598-021-02128-y
pmc: PMC8626481
doi:
Substances chimiques
Antigens, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23009Informations de copyright
© 2021. The Author(s).
Références
Lancet. 2021 Apr 17;397(10283):1425-1427
pubmed: 33609444
Diagnostics (Basel). 2021 Jun 30;11(7):
pubmed: 34208912
Lancet Microbe. 2021 Jan;2(1):e13-e22
pubmed: 33521734
BMJ. 2020 Dec 11;371:m4787
pubmed: 33310701
Clin Infect Dis. 2020 Dec 03;:
pubmed: 33270107
Lancet Infect Dis. 2021 Jul;21(7):e183-e190
pubmed: 33357517
J Med Virol. 2021 Apr;93(4):2177-2195
pubmed: 33095454
N Engl J Med. 2020 Nov 26;383(22):e120
pubmed: 32997903
J Clin Microbiol. 2021 Feb 18;59(3):
pubmed: 33310764