Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 11 2021
26 11 2021
Historique:
received:
09
09
2021
accepted:
10
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
1
2
2022
Statut:
epublish
Résumé
This study aimed to assess the degree of differentiation of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1 relaxometry. Thirty-three solitary HCC lesions were included in this retrospective study. This study's inclusion criteria were preoperative Gd-EOB-DTPA-assisted MRI of the liver and a histopathological evaluation after hepatic tumor resection. T1 maps of the liver were evaluated to determine the T1 relaxation time and reduction rate between the native phase and hepatobiliary phase (HBP) in liver lesions. These findings were correlated with the histopathologically determined degree of HCC differentiation (G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated). There was no significant difference between well-differentiated (950.2 ± 140.2 ms) and moderately/poorly differentiated (1009.4 ± 202.0 ms) HCCs in the native T1 maps. After contrast medium administration, a significant difference (p ≤ 0.001) in the mean T1 relaxation time in the HBP was found between well-differentiated (555.4 ± 140.2 ms) and moderately/poorly differentiated (750.9 ± 146.4 ms) HCCs. For well-differentiated HCCs, the reduction rate in the T1 time was significantly higher at 0.40 ± 0.15 than for moderately/poorly differentiated HCCs (0.25 ± 0.07; p = 0.006). In conclusion this study suggests that the uptake of Gd-EOB-DTPA in HCCs is correlated with tumor grade. Thus, Gd-EOB-DTPA-assisted T1 relaxometry can help to further differentiation of HCC.
Identifiants
pubmed: 34837039
doi: 10.1038/s41598-021-02499-2
pii: 10.1038/s41598-021-02499-2
pmc: PMC8626433
doi:
Substances chimiques
Contrast Media
0
gadolinium ethoxybenzyl DTPA
0
Gadolinium DTPA
K2I13DR72L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22991Informations de copyright
© 2021. The Author(s).
Références
Magn Reson Med. 2010 Aug;64(2):439-46
pubmed: 20665788
Dtsch Arztebl Int. 2014 Feb 14;111(7):101-6
pubmed: 24622679
Cancer Biol Ther. 2005 Aug;4(8):815-8
pubmed: 16210916
Sci Rep. 2017 Mar 07;7:43347
pubmed: 28266528
Radiology. 2017 Feb;282(2):408-417
pubmed: 27697007
Eur Radiol. 2008 Mar;18(3):457-67
pubmed: 18058107
Acta Radiol. 2016 Aug;57(8):932-8
pubmed: 26586852
Ann Surg. 2011 Jan;253(1):166-72
pubmed: 21294289
Drug Metab Pharmacokinet. 2008;23(5):347-55
pubmed: 18974612
J Hepatol. 2001 Apr;34(4):570-5
pubmed: 11394657
Drug Metab Dispos. 2010 Jul;38(7):1024-8
pubmed: 20406852
J Cancer Res Clin Oncol. 2004 Jul;130(7):417-22
pubmed: 15042359
Invest Radiol. 2010 Mar;45(3):133-41
pubmed: 20098330
J Magn Reson Imaging. 1996 May-Jun;6(3):472-7
pubmed: 8724413
Liver Transpl. 2002 Dec;8(12):1165-74
pubmed: 12474157
AJR Am J Roentgenol. 2009 Jun;192(6):1675-81
pubmed: 19457834
BMC Cancer. 2016 Aug 12;16:625
pubmed: 27520833
Clin Pharmacol Ther. 2007 Feb;81(2):194-204
pubmed: 17192770
Magn Reson Med. 2003 Mar;49(3):515-26
pubmed: 12594755
Eur J Radiol Open. 2020 Dec 24;8:100312
pubmed: 33392362
Liver Transpl. 2011 Oct;17 Suppl 2:S14-25
pubmed: 21744470
J Gastroenterol. 2009;44 Suppl 19:112-8
pubmed: 19148804
J Gastroenterol. 2009;44(7):793-8
pubmed: 19404564
AJR Am J Roentgenol. 2009 Oct;193(4):1053-60
pubmed: 19770329
Liver Transpl. 2007 Nov;13(11 Suppl 2):S17-23
pubmed: 17969095
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
pubmed: 21296855
Front Med (Lausanne). 2017 Nov 10;4:193
pubmed: 29209611
Liver Int. 2005 Apr;25(2):367-79
pubmed: 15780063
Radiology. 2010 Jun;255(3):824-33
pubmed: 20501720
Abdom Imaging. 2014 Dec;39(6):1202-12
pubmed: 24869790
Gastroenterology. 2001 Jun;120(7):1689-99
pubmed: 11375950
Liver Transpl. 2000 Jan;6(1):67-72
pubmed: 10648580
Transpl Int. 2003 Feb;16(2):115-22
pubmed: 12595973
Sci Rep. 2015 Oct 19;5:15408
pubmed: 26478097
Ann Surg. 2004 Feb;239(2):150-9
pubmed: 14745321
N Engl J Med. 1996 Mar 14;334(11):693-9
pubmed: 8594428
Radiology. 2013 Jun;267(3):776-86
pubmed: 23401584
Arch Surg. 2001 Jan;136(1):25-30; discussion 31
pubmed: 11146770
Hepatology. 2001 May;33(5):1080-6
pubmed: 11343235
Biomedicines. 2020 Oct 13;8(10):
pubmed: 33066169
Rofo. 2015 Oct;187(10):863-71
pubmed: 26230140
J Magn Reson Imaging. 2001 Mar;13(3):397-401
pubmed: 11241813
Radiology. 2005 Feb;234(2):468-78
pubmed: 15591431
N Engl J Med. 2011 Sep 22;365(12):1118-27
pubmed: 21992124
BMC Cancer. 2019 Apr 18;19(1):364
pubmed: 30999947
Liver. 1987 Feb;7(1):18-26
pubmed: 3033422
J Hepatol. 2016 Mar;64(3):708-16
pubmed: 26632635
Med Clin (Barc). 2018 May 23;150(10):390-397
pubmed: 29096967
J Biol Chem. 1999 Jun 11;274(24):17159-63
pubmed: 10358072
J Hepatol. 2001 Apr;34(4):603-5
pubmed: 11394662
Hepatology. 2005 Nov;42(5):1208-36
pubmed: 16250051
J Pharmacol Exp Ther. 2003 Jan;304(1):223-8
pubmed: 12490595
Int J Cancer. 2001 Nov;94(4):492-9
pubmed: 11745434
Z Gastroenterol. 2013 Nov;51(11):1269-326
pubmed: 24243572
Ann Surg. 2007 Mar;245(3):435-42
pubmed: 17435551
J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):1029-1036
pubmed: 29254310