Innovations and advances in modelling and measuring pain in animals.
Journal
Nature reviews. Neuroscience
ISSN: 1471-0048
Titre abrégé: Nat Rev Neurosci
Pays: England
ID NLM: 100962781
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
accepted:
20
10
2021
pubmed:
28
11
2021
medline:
26
2
2022
entrez:
27
11
2021
Statut:
ppublish
Résumé
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past decade as a result of technological advancements, the continued dearth of translational progress and the emphasis that funding institutions and journals have placed on rigour and reproducibility. Here we describe the changing trends in research methods by analysing the methods reported in preclinical pain publications from the past 40 years, with a focus on the last 5 years. We also discuss how the status quo may be hampering translational success. This discussion is centred on four fundamental decisions that apply to every pain behaviour experiment: choice of subject (model organism), choice of assay (pain-inducing injury), laboratory environment and choice of outcome measures. Finally, we discuss how human tissues, which are increasingly accessible, can be used to validate the translatability of targets and mechanisms identified in animal pain models.
Identifiants
pubmed: 34837072
doi: 10.1038/s41583-021-00536-7
pii: 10.1038/s41583-021-00536-7
pmc: PMC9098196
mid: NIHMS1803254
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-85Subventions
Organisme : NINDS NIH HHS
ID : R37 NS108278
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NINDS NIH HHS
ID : R01 NS040538
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070711
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL155791
Pays : United States
Informations de copyright
© 2021. Springer Nature Limited.
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