The Ki-67 antigen in the new 2021 World Health Organization classification of lung neuroendocrine neoplasms.
Ki-67
carcinoid
carcinoma
lung
neoplasms
neuroendocrine
Journal
Pathologica
ISSN: 1591-951X
Titre abrégé: Pathologica
Pays: Italy
ID NLM: 0401123
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
24
10
2021
accepted:
24
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
1
12
2021
Statut:
ppublish
Résumé
Prof. Rosai's work has permeated the surgical pathology in many fields, including the 2017 World Health Organization classification on tumors of endocrine organs and pulmonary neuroendocrine cell pathology, with stimulating contributions which have also anticipated the subsequent evolution of knowledge. Among the many studies authored by Prof. Rosai, we would like to recall one of which whose topic has been encased in the new 2021 World Health Organization classification on lung tumors. This is an eminently practical paper dealing with the use of the proliferation antigen Ki-67 in lung neuroendocrine neoplasms. While these neoplasms are primarily ranked upon histologic features and Ki-67 labeling index does not play any role in classification, diagnostic dilemmas may however arise in severely crushed biopsy or cytology samples where this marker proves helpful to avoid misdiagnoses of carcinoids as small cell carcinoma. Another application of Ki-67 labeling index endorsed by the 2021 World Health Organization classification regards, alongside mitotic count, the emerging recognition of lung atypical carcinoids with increased mitotic or proliferation rates, whose biological boundaries straddle a subset of large cell neuroendocrine carcinoma. This article focuses on these two practical applications of the proliferation marker Ki-67 in keeping with the 2021 World Health Organization classification, which provides standards for taxonomy, diagnosis and clinical decision making in lung neuroendocrine neoplasm patients.
Identifiants
pubmed: 34837096
doi: 10.32074/1591-951X-542
pmc: PMC8720414
doi:
Substances chimiques
Ki-67 Antigen
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
377-387Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
Copyright © 2021 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
Références
Endocr Pathol. 2021 Mar;32(1):154-168
pubmed: 33641055
Mod Pathol. 2018 Dec;31(12):1770-1786
pubmed: 30140036
Clin Cancer Res. 2016 Jul 15;22(14):3618-29
pubmed: 26960398
Mod Pathol. 2011 Apr;24 Suppl 2:S53-7
pubmed: 21455201
ORL J Otorhinolaryngol Relat Spec. 1991;53(4):185-7
pubmed: 1653927
Nature. 2016 Jun 29;535(7611):308-12
pubmed: 27362226
Monogr Pathol. 1987;(29):161-83
pubmed: 3035367
Cancer. 1979 Jun;43(6):2438-51
pubmed: 222426
Am J Surg Pathol. 1995 Aug;19(8):963-70
pubmed: 7611544
Turk Patoloji Derg. 2019;35(1):15-21
pubmed: 30070306
J Thorac Oncol. 2019 Aug;14(8):1472-1483
pubmed: 31042566
J Thorac Oncol. 2021 Apr;16(4):610-618
pubmed: 33333326
Hum Pathol. 1996 Nov;27(11):1124-34
pubmed: 8912819
Neuroendocrinology. 2019;108(2):109-120
pubmed: 30485860
Trends Cell Biol. 2017 Dec;27(12):906-916
pubmed: 28838621
Elife. 2016 Mar 07;5:e13722
pubmed: 26949251
Radiat Oncol. 2017 Jan 13;12(1):16
pubmed: 28086989
Curr Oncol. 2018 Jun;25(Suppl 1):S86-S93
pubmed: 29910651
Front Endocrinol (Lausanne). 2011 Aug 19;2:20
pubmed: 22654796
Ann Oncol. 2015 Aug;26(8):1604-20
pubmed: 25646366
Hum Pathol. 2003 Oct;34(10):1061-5
pubmed: 14608543
Cancer. 1972 Apr;29(4):1061-74
pubmed: 4111691
Virchows Arch. 2017 Jul;471(1):31-47
pubmed: 28451756
Clin Transl Oncol. 2018 May;20(5):570-575
pubmed: 29058263
Lung Cancer. 2015 Mar;87(3):226-31
pubmed: 25620799
Diagn Pathol. 2019 Sep 12;14(1):104
pubmed: 31511024
Arch Pathol Lab Med. 1976 Jun;100(6):293-300
pubmed: 946757
Nat Commun. 2019 Aug 20;10(1):3407
pubmed: 31431620
Am J Surg Pathol. 2005 Feb;29(2):179-87
pubmed: 15644774
Lung Cancer Int. 2015;2015:545601
pubmed: 26770831
Am J Surg Pathol. 1995 Jun;19(6):642-52
pubmed: 7538732
Cancer. 1972 Apr;29(4):1075-83
pubmed: 4401563
Mod Pathol. 2019 Jul;32(8):1106-1122
pubmed: 30923345
Open Biol. 2021 Aug;11(8):210120
pubmed: 34375547
Am J Surg Pathol. 1995 Jun;19(6):659-65
pubmed: 7755152
Mod Pathol. 2018 Oct;31(10):1523-1531
pubmed: 29802361
Am J Surg Pathol. 1997 Jul;21(7):754-62
pubmed: 9236831
J Thorac Oncol. 2019 Mar;14(3):377-407
pubmed: 30572031
Cancer. 1991 Feb 15;67(4):1025-32
pubmed: 1991250
Expert Rev Mol Diagn. 2019 Apr;19(4):281-297
pubmed: 30900485
Am J Surg Pathol. 2020 Feb;44(2):224-231
pubmed: 31490236
J Thorac Oncol. 2016 Mar;11(3):e35-8
pubmed: 26723240
Trends Biochem Sci. 2018 Oct;43(10):747-748
pubmed: 30131191
Am J Clin Pathol. 1997 Nov;108(5):537-43
pubmed: 9353092
Virchows Arch. 2017 Feb;470(2):153-164
pubmed: 28054150
J Thorac Oncol. 2014 Mar;9(3):273-84
pubmed: 24518085
Am J Clin Pathol. 2005 Jun;123(6):874-8
pubmed: 15899778
Semin Diagn Pathol. 1991 Feb;8(1):35-51
pubmed: 1646476
Cell Rep. 2018 Jul 31;24(5):1105-1112.e5
pubmed: 30067968
Pathol Annu. 1976;11:201-26
pubmed: 188002
Histopathology. 2017 Feb;70(3):412-422
pubmed: 27701763
Pathol Res Pract. 1988 Apr;183(2):188-99
pubmed: 3290867
Semin Diagn Pathol. 1998 May;15(2):144-54
pubmed: 9606805
Virchows Arch. 2018 Apr;472(4):567-577
pubmed: 29388013
Int J Surg Pathol. 2000 Apr;8(2):109-117
pubmed: 11493975
Ann Oncol. 2005 Aug;16(8):1374-80
pubmed: 15939719
Surg Pathol Clin. 2020 Mar;13(1):35-55
pubmed: 32005434
Am J Pathol. 1988 May;131(2):258-69
pubmed: 3282444
Virchows Arch. 2021 Jul;479(1):121-131
pubmed: 33464376
Ecancermedicalscience. 2017 Sep 11;11:767
pubmed: 28955403
J Cell Sci. 2018 Mar 22;131(6):
pubmed: 29487178
Int J Cancer. 2016 Feb 15;138(4):927-38
pubmed: 26340530
Mod Pathol. 2012 Sep;25(9):1258-64
pubmed: 22575865
Virchows Arch. 2017 Dec;471(6):713-720
pubmed: 28631159
Am J Surg Pathol. 2017 Feb;41(2):263-270
pubmed: 27879513
J Thorac Oncol. 2015 Sep;10(9):1240-1242
pubmed: 26291007
Clin Pathol. 2019 Feb 19;12:2632010X19829259
pubmed: 31041430
Am J Clin Pathol. 2020 Jan 2;153(2):165-174
pubmed: 31593583
Am J Surg Pathol. 1996 Aug;20(8):944-55
pubmed: 8712294
Endocr Pathol. 2014 Jun;25(2):151-64
pubmed: 24771462
Int J Surg Pathol. 2001 Apr;9(2):87-92
pubmed: 11484507
Chromosoma. 2018 Jun;127(2):175-186
pubmed: 29322240
J Thorac Oncol. 2017 Mar;12(3):425-436
pubmed: 27890494
Endocr Relat Cancer. 2013 Dec 16;21(1):1-16
pubmed: 24344249
Am J Surg Pathol. 1998 Sep;22(9):1059-66
pubmed: 9737237