COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations.
COVID-19
Metabolomics
Multi-omics
Multiorgan
Neuroinflammation
SARS-CoV-2
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
08
11
2021
received:
11
09
2021
accepted:
22
11
2021
pubmed:
28
11
2021
medline:
11
3
2022
entrez:
27
11
2021
Statut:
ppublish
Résumé
Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome in COVID-19. We performed an in-depth assessment of 1129 unique metabolites in 27 hospitalized COVID-19 patients and integrated results with large-scale proteomic and immunology data to capture multiorgan system perturbations. More than half of the detected metabolic alterations in COVID-19 were driven by patient-specific confounding factors ranging from comorbidities to xenobiotic substances. Systematically adjusting for this, a COVID-19-specific metabolic imprint was defined which, over time, underwent a switch in response to severe acute respiratory syndrome coronavirus-2 seroconversion. Integration of the COVID-19 metabolome with clinical, cellular, molecular, and immunological severity scales further revealed a network of metabolic trajectories aligned with multiple pathways for immune activation, and organ damage including neurological inflammation and damage. Altogether, this resource refines our understanding of the multiorgan system perturbations in severe COVID-19 patients.
Identifiants
pubmed: 34837225
doi: 10.1002/eji.202149626
pmc: PMC9015354
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
503-510Subventions
Organisme : Knut and Alice Wallenberg Foundation
Organisme : Nordstjernan AB
Organisme : Center for Innovative Medicine at Karolinska Institutet
Organisme : Region Stockholm
Organisme : European Research Council
ID : 948692
Pays : International
Informations de copyright
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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