Convenient Synthesis of 3-Deazapurine Nucleosides (3-Deazainosine, 3-Deazaadenosine and 3-Deazaguanosine) Using Inosine as a Starting Material.
3-deazaadenosine
3-deazaguanosine
3-deazainosine
3-deazapurine nucleoside
inosine
Journal
Current protocols
ISSN: 2691-1299
Titre abrégé: Curr Protoc
Pays: United States
ID NLM: 101773894
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
1
12
2021
Statut:
ppublish
Résumé
A convenient synthetic method for preparing 3-deazapurine nucleosides (3-deazainosine, 3-deazaadenosine, and 3-deazaguanosine) from inosine via a 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) derivative, which is a key intermediate, is described. A large-scale synthesis of an EICAR derivative starting from inosine was achieved in six steps via dinitrophenylation at the N
Substances chimiques
Nucleosides
0
3-deazaadenosine
037V4520IY
Guanosine
12133JR80S
3-deazaguanosine
56039-11-3
Inosine
5A614L51CT
Tubercidin
M351LCX45Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e297Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
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