Sperm Associated Antigens: Vigorous Influencers in Life.

Antigen Cancer Fertility Human Sperm

Journal

Cell journal
ISSN: 2228-5806
Titre abrégé: Cell J
Pays: Iran
ID NLM: 101566618

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 05 01 2020
accepted: 27 06 2020
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 28 11 2021
Statut: ppublish

Résumé

Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm's function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.

Identifiants

pubmed: 34837675
doi: 10.22074/cellj.2021.7377
pmc: PMC8588810
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

495-502

Informations de copyright

Copyright© by Royan Institute. All rights reserved.

Déclaration de conflit d'intérêts

There is no conflict of interest in this study.

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Auteurs

Samaneh Faraji (S)

Department of Molecular and Cellular Biology, Faculty of Basic Science and Advanced Technologies in Biology, University of Science and Culture, ACECR, Tehran, Iran.
. Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Mohsen Sharafi (M)

Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Abdol Hossein Shahverdi (AH)

. Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Email: shahverdi@royaninstitute.org.
Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Rouhollah Fathi (R)

Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Email: rfathi79@royaninstitute.org.

Classifications MeSH