Aging-associated immune system changes in multiple myeloma: The dark side of the moon.
Immune microenvironment
Immunosenescence
Inflammaging
Myeloma
Journal
Cancer treatment and research communications
ISSN: 2468-2942
Titre abrégé: Cancer Treat Res Commun
Pays: England
ID NLM: 101694651
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
12
2020
accepted:
18
11
2021
pubmed:
28
11
2021
medline:
11
3
2022
entrez:
27
11
2021
Statut:
ppublish
Résumé
Multiple myeloma (MM) is a disease of the elderly. Changes that occur in the immune system with aging, also known as immunosenescence, have been associated with decreased tumor immunosurveillance and are thought to contribute to the development of MM and other cancers in the elderly. Once MM establishes itself in the bone marrow, immunosenescence related changes have been observed in the immune tumor microenvironment (iTME) and are driven by the malignant cells. The efficacy of novel immunotherapies used to treat MM has been blunted by detrimental iTME changes that occur at later disease stages and are, to some extent, driven by prior therapies. In this review, we discuss general changes that occur in the immune system with aging as well as our current knowledge of immunosenescence in MM. We discuss the differences and overlap between T cell senescence and exhaustion as well as potential methods to prevent or reverse immunosenescence. We focus predominantly on T cell immunosenescence which has been better evaluated in this disease and is more pertinent to novel MM immunotherapies. Our lack of understanding of the drivers of immunosenescence at each stage of the disease, from precursor stages to heavily pretreated MM, represents a major barrier to improving the efficacy of novel and existing therapies.
Identifiants
pubmed: 34837796
pii: S2468-2942(21)00190-8
doi: 10.1016/j.ctarc.2021.100494
pmc: PMC8744501
mid: NIHMS1759579
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100494Subventions
Organisme : NCI NIH HHS
ID : K12 CA090628
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA186781
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Références
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Leukemia. 2012 Jan;26(1):149-57
pubmed: 21799510
Blood. 2014 Jan 9;123(2):239-48
pubmed: 24191150
Exp Gerontol. 1999 Dec;34(8):959-70
pubmed: 10673149
Oncologist. 2016 Nov;21(11):1355-1361
pubmed: 27486203
Protein Cell. 2020 Oct;11(10):740-770
pubmed: 32780218
PLoS One. 2013;8(3):e58504
pubmed: 23544044
Leukemia. 2021 Feb;35(2):573-584
pubmed: 32457357
J Immunol. 2003 Sep 1;171(5):2326-30
pubmed: 12928378
Arthritis Rheum. 2005 Oct;52(10):2996-3003
pubmed: 16200579
Exp Gerontol. 2002 Jan-Mar;37(2-3):389-94
pubmed: 11772525
BMC Immunol. 2010 Jun 21;11:30
pubmed: 20565954
Cell Rep. 2019 Feb 19;26(8):2178-2193.e3
pubmed: 30784598
N Engl J Med. 1990 Mar 8;322(10):664-8
pubmed: 2137556
Exp Gerontol. 2004 Apr;39(4):577-85
pubmed: 15050293
Br J Haematol. 2020 Dec;191(5):784-795
pubmed: 32558939
J Hematol Oncol. 2016 Nov 3;9(1):116
pubmed: 27809856
Bone. 2016 Oct;91:81-91
pubmed: 27423464
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Br J Cancer. 2003 Mar 24;88(6):855-62
pubmed: 12644822
Cell Death Dis. 2015 Jun 18;6:e1792
pubmed: 26086965
Oncotarget. 2018 Apr 17;9(29):20476-20489
pubmed: 29755666
J Exp Med. 2008 Jul 7;205(7):1701-14
pubmed: 18573906
Mech Ageing Dev. 2004 Feb;125(2):137-43
pubmed: 15037019
Nat Commun. 2015 Mar 26;6:6692
pubmed: 25809635
Front Immunol. 2017 Jul 26;8:896
pubmed: 28798751
Nat Immunol. 2019 Mar;20(3):326-336
pubmed: 30778252
Blood. 2003 Jun 1;101(11):4260-6
pubmed: 12576317
Eur J Immunol. 2015 May;45(5):1441-51
pubmed: 25707450
Blood. 2011 Aug 4;118(5):1294-304
pubmed: 21562046
J Biol Chem. 2004 Jul 9;279(28):29130-8
pubmed: 15128741
Cell Immunol. 1995 May;162(2):248-55
pubmed: 7743552
Immunology. 2011 Mar;132(3):326-39
pubmed: 21214539
Leukemia. 2016 Feb;30(2):492-500
pubmed: 26369987
Biomed Res Int. 2018 Nov 26;2018:9434637
pubmed: 30599001
Blood. 2016 Apr 14;127(15):1896-906
pubmed: 26755711
Nat Immunol. 2006 May;7(5):507-16
pubmed: 16617337
Haematologica. 2017 Apr;102(4):773-784
pubmed: 28057743
Blood. 2013 Apr 11;121(15):2975-87
pubmed: 23321256
Proc Natl Acad Sci U S A. 2018 May 1;115(18):4749-4754
pubmed: 29654146
Nat Biotechnol. 2018 Apr;36(4):346-351
pubmed: 29505028
J Immunol. 2009 Apr 1;182(7):4237-43
pubmed: 19299722
J Immunol. 2001 Sep 15;167(6):3231-8
pubmed: 11544310
Aging Cell. 2018 Feb;17(1):
pubmed: 29024417
J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):163-172
pubmed: 27069096
J Immunol. 2013 Mar 1;190(5):2403-14
pubmed: 23355732
Oncoimmunology. 2016 Oct 7;5(12):e1237327
pubmed: 28123872
Front Immunol. 2017 Aug 15;8:982
pubmed: 28861086
Blood Adv. 2017 Jun 20;1(15):1056-1066
pubmed: 29296748
Nat Immunol. 2020 Jun;21(6):684-694
pubmed: 32231301
Cell Death Dis. 2012 Dec 20;3:e446
pubmed: 23254289
Science. 2014 Jan 17;343(6168):301-5
pubmed: 24292625
Immun Inflamm Dis. 2015 Jun;3(2):94-102
pubmed: 26029369
Clin Cancer Res. 2020 Oct 15;26(20):5494-5505
pubmed: 32816947
J Immunol. 2005 Dec 15;175(12):8415-23
pubmed: 16339584
J Immunol. 2014 Mar 1;192(5):2143-55
pubmed: 24501199
JCI Insight. 2019 Apr 23;5:
pubmed: 31013254
Exerc Sport Sci Rev. 2011 Jan;39(1):23-33
pubmed: 21088603
Front Immunol. 2020 Sep 03;11:2153
pubmed: 33013907
Aging Cell. 2017 Jun;16(3):480-487
pubmed: 28229533
Biol Blood Marrow Transplant. 2018 Apr;24(4):666-677
pubmed: 29197680
Clin Cancer Res. 2010 Jan 15;16(2):727-35
pubmed: 20068111
Mayo Clin Proc. 1994 Jul;69(7):684-90
pubmed: 8015335
Immun Ageing. 2008 Jul 25;5:6
pubmed: 18657274
Nat Rev Immunol. 2011 Apr;11(4):289-95
pubmed: 21436838
Blood Cancer J. 2019 Aug 28;9(9):72
pubmed: 31462637
Blood Adv. 2019 Oct 8;3(19):2812-2815
pubmed: 31575532
Cytometry A. 2019 Mar;95(3):279-289
pubmed: 30536810
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21432-7
pubmed: 23236163
J Immunol. 1998 Nov 1;161(9):4472-5
pubmed: 9794368
Leukemia. 2002 Oct;16(10):2142-7
pubmed: 12357369
J Leukoc Biol. 2004 Feb;75(2):342-9
pubmed: 14634059
Mech Ageing Dev. 2000 Sep 1;118(1-2):45-59
pubmed: 10989124
J Immunol. 2011 Sep 1;187(5):2093-100
pubmed: 21788446
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9194-9
pubmed: 15967997
J Clin Invest. 1996 May 1;97(9):2027-37
pubmed: 8621791
Blood. 1996 Sep 15;88(6):2219-27
pubmed: 8822942
Exp Hematol. 2010 Oct;38(10):860-7
pubmed: 20619313
Aging Cell. 2010 Aug;9(4):527-35
pubmed: 20477761
Nature. 2001 Mar 1;410(6824):37-40
pubmed: 11242034
Blood. 1997 Aug 15;90(4):1649-55
pubmed: 9269785
Proc Natl Acad Sci U S A. 2006 May 30;103(22):8447-52
pubmed: 16717190
Blood. 2016 Mar 3;127(9):1151-62
pubmed: 26668134
Cell Biol Int. 2003;27(12):959-64
pubmed: 14642527
Biol Blood Marrow Transplant. 2020 Jan;26(1):7-15
pubmed: 31445183
Blood. 2012 Aug 2;120(5):1067-76
pubmed: 22498740
J Immunol. 2008 Aug 1;181(3):1835-48
pubmed: 18641321
Nat Med. 2018 May;24(5):563-571
pubmed: 29713085
Immunity. 2012 Feb 24;36(2):288-97
pubmed: 22365666
Exp Gerontol. 2003 Oct;38(10):1109-18
pubmed: 14580864
Immunity. 2019 Aug 20;51(2):351-366.e6
pubmed: 31303400
J Clin Pathol. 2016 Apr 15;:
pubmed: 27083212
Protein Cell. 2019 Oct;10(10):764-769
pubmed: 31250350
Leukemia. 2014 May;28(5):1122-8
pubmed: 24157580
Nat Immunol. 2014 Oct;15(10):965-72
pubmed: 25151490
J Clin Invest. 2013 Dec;123(12):5247-57
pubmed: 24231352
Cell. 2018 May 31;173(6):1385-1397.e14
pubmed: 29706550
Blood. 2012 Sep 6;120(10):2021-31
pubmed: 22723548
J Leukoc Biol. 2006 May;79(5):1061-72
pubmed: 16501054
J Clin Immunol. 2010 Nov;30(6):806-13
pubmed: 20703784
Blood. 2009 Jun 25;113(26):6619-28
pubmed: 19406987
J Immunol. 2001 Dec 15;167(12):6869-76
pubmed: 11739504
Aging Cell. 2017 Apr;16(2):293-303
pubmed: 28026094
Bone Marrow Transplant. 2015 Oct;50(10):1379-81
pubmed: 26121107
Blood Cancer J. 2017 Jun 30;7(6):e579
pubmed: 28665418
Cancer Immunol Res. 2016 Jan;4(1):61-71
pubmed: 26464015
Mayo Clin Proc. 2009 Feb;84(2):114-22
pubmed: 19181644
J Hematol Oncol. 2020 Nov 10;13(1):151
pubmed: 33168037
Cell Mol Life Sci. 2019 May;76(10):1901-1918
pubmed: 30788516
J Clin Invest. 2014 Sep;124(9):4004-16
pubmed: 25083993
Lancet Oncol. 2020 Feb;21(2):207-221
pubmed: 31859245
Blood Cancer J. 2017 Dec 15;7(12):649
pubmed: 29242558
J Immunol. 2013 Oct 1;191(7):3744-52
pubmed: 23997212
Leukemia. 2018 Dec;32(12):2636-2647
pubmed: 29895955
Biogerontology. 2007 Apr;8(2):173-87
pubmed: 17086367
J Immunol. 2015 Sep 1;195(5):1933-7
pubmed: 26297793
Trends Mol Med. 2010 May;16(5):238-46
pubmed: 20444648
Clin Exp Immunol. 1992 Nov;90(2):351-4
pubmed: 1424294
Leukemia. 2018 May;32(5):1157-1167
pubmed: 29479065
Nat Commun. 2018 Jan 16;9(1):249
pubmed: 29339767
Nat Immunol. 2005 Apr;6(4):390-5
pubmed: 15735648
Blood. 2003 Apr 1;101(7):2711-20
pubmed: 12433688
Leukemia. 2016 Aug;30(8):1716-24
pubmed: 27102208
Blood. 2020 Jul 9;136(2):199-209
pubmed: 32325491
J Clin Invest. 2009 May;119(5):1167-77
pubmed: 19381021
Semin Immunol. 2012 Oct;24(5):373-82
pubmed: 22633440
Aging (Albany NY). 2020 Nov 18;12(22):22445-22456
pubmed: 33206062
Blood. 2005 Jul 15;106(2):558-65
pubmed: 15797994
Aging Cell. 2009 Feb;8(1):18-25
pubmed: 18986373
Leuk Res. 2007 May;31(5):591-8
pubmed: 16879867
J Immunol. 2013 Apr 1;190(7):3815-23
pubmed: 23460744
Cell Mol Immunol. 2020 Jan;17(1):27-35
pubmed: 31853000
Oncotarget. 2017 Oct 5;8(58):98200-98214
pubmed: 29228683
FEBS Lett. 2004 Sep 10;574(1-3):37-41
pubmed: 15358536
Blood. 2016 Jul 21;128(3):384-94
pubmed: 27222480