15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword.
15-lipoxygenase-1
15-lipoxygenase-2
Apoptosis
Breast cancer
Cell growth
Metastasis
Journal
Lipids in health and disease
ISSN: 1476-511X
Titre abrégé: Lipids Health Dis
Pays: England
ID NLM: 101147696
Informations de publication
Date de publication:
27 Nov 2021
27 Nov 2021
Historique:
received:
30
08
2021
accepted:
11
11
2021
entrez:
28
11
2021
pubmed:
29
11
2021
medline:
18
3
2022
Statut:
epublish
Résumé
15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth. Aberrant expression of 15-lipoxygenase enzyme seems to play an indicative role in the pathology of different cancer types, tumor progression, metastasis, or apoptosis. Based on the fact that breast cancer is one of the most common cancers that imposes a burden of mortality in women also, on the other hand, evidence in experimental models and human studies indicate the emerging role of the 15-lipoxygenase pathway in breast cancer pathogenesis, we present a review of recent findings related to the role of 15- lipoxygenase enzyme and metabolites in breast cancer growth, apoptosis, metastasis, and invasion as well as their local and circulating expression pattern in patients with breast cancer. Our review supports the emerging role of 15- lipoxygenase in molecular and cellular processes regulating breast tumor cell fate with both positive and negative effects.
Identifiants
pubmed: 34838055
doi: 10.1186/s12944-021-01599-2
pii: 10.1186/s12944-021-01599-2
pmc: PMC8627626
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
169Subventions
Organisme : Iran University of Medical Sciences
ID : 93-02-30-24469
Informations de copyright
© 2021. The Author(s).
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