Building human renal tracts.
Collecting duct
Implant
Nephron
Pluripotent stem cell
Ureter
Journal
Journal of pediatric surgery
ISSN: 1531-5037
Titre abrégé: J Pediatr Surg
Pays: United States
ID NLM: 0052631
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
04
10
2021
accepted:
22
10
2021
pubmed:
29
11
2021
medline:
9
2
2022
entrez:
28
11
2021
Statut:
ppublish
Résumé
Severe kidney failure affects several million people worldwide. Among these are children born with abnormal renal tracts, and some carry mutations of genes active in renal tract development. Kidney transplants are in short supply, and long term dialysis does not obviate uraemia and its associated harmful effects. It has been envisaged that a combination of stem cell technology, developmental biology, and genetics will revolutionise our understanding of kidney disease and provide novel therapies for kidney failure. Here, we review progress towards making functional kidney tissues from human pluripotent stem cells. Organoids rich in immature glomeruli and tubules can be created in culture from pluripotent stem cells. Moreover, differentiation can be increased by implanting these cells into immunodeficient mice. Challenges remain to be overcome, however, before these tissues can be used for regenerative medicine therapies. Current limitations include the small size of an organoid, the lack of large blood vessels feeding it, and the lack of a urinary tract to plumb the kidney organoid. Pluripotent stem cell technology is also being used to create 'diseases in a dish' to understand the pathobiology underlying human renal tract malformations.
Identifiants
pubmed: 34838308
pii: S0022-3468(21)00735-1
doi: 10.1016/j.jpedsurg.2021.10.022
pmc: PMC8837266
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
172-177Subventions
Organisme : Medical Research Council
ID : MR/T016809/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Author. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The author declared no competing interests.
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