Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage.
Alzheimer's
Basal forebrain cholinergic neurons
Dystrophic neurites
Neurotrophin
Tau pathology
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
13
07
2021
revised:
05
11
2021
accepted:
22
11
2021
pubmed:
29
11
2021
medline:
8
4
2022
entrez:
28
11
2021
Statut:
ppublish
Résumé
Degeneration of basal forebrain cholinergic neurons (BFCNs) in the nucleus basalis of Meynert (NBM) and vertical diagonal band (VDB) along with their connections is a key pathological event leading to memory impairment in Alzheimer's disease (AD). Aberrant neurotrophin signaling via Trks and the p75 neurotrophin receptor (p75
Identifiants
pubmed: 34838668
pii: S0969-9961(21)00312-0
doi: 10.1016/j.nbd.2021.105563
pii:
doi:
Substances chimiques
Nerve Growth Factors
0
Receptors, Nerve Growth Factor
0
Receptor, trkC
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105563Subventions
Organisme : NIA NIH HHS
ID : R21 AG053856
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.