Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?

Antitubercular Agents / pharmacology Biofilms / drug effects Humans Mycobacterium tuberculosis / genetics Tuberculosis / metabolism
Biofilms Extracellular communities Mycobacterium Pulmonary pathogenesis Tuberculosis

Journal

Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555

Informations de publication

Date de publication:
01 2022
Historique:
received: 24 09 2021
revised: 09 11 2021
accepted: 21 11 2021
pubmed: 29 11 2021
medline: 11 3 2022
entrez: 28 11 2021
Statut: ppublish

Résumé

Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new appreciation of extracellular TB phenotypes found in lung lesions will drive drug and vaccine discovery forward to new possibilities.

Identifiants

DOI: 10.1016/j.tube.2021.102153 PMID: 34839080
pubmed: 34839080
pii: S1472-9792(21)00103-7
doi: 10.1016/j.tube.2021.102153
pii:
doi:

Substances chimiques

Antitubercular Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102153

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Joanna Bacon (J)

TB Discovery Group, National Infection Service, Public Health England, Porton Down, Salisbury, SP4 0JG, UK.

Simon J Waddell (SJ)

Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, UK.

Mario Alberto Flores-Valdez (MA)

Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C. Biotecnología Médica y Farmacéutica. Av. Normalistas 800, Col. Colinas de la Normal, Guadalajara, Jalisco, 44270, Mexico. Electronic address: floresv@ciatej.mx.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Biofilms in tuberculosis: What have we learnt...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Biofilms in tuberculosis: What have we learnt...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biofilms in tuberculosis: What have we learnt...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Biofilms in tuberculosis: What have we learnt...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Biofilms in tuberculosis: What have we learnt...