Dysregulated CD40 and CD40 ligand expression in anti-N-methyl-d-aspartate receptor encephalitis.
Anti–N-methyl-d-aspartate receptor encephalitis
CD40
CD40 ligand
Pathway
Serum
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 01 2022
15 01 2022
Historique:
received:
21
05
2021
revised:
26
10
2021
accepted:
31
10
2021
pubmed:
29
11
2021
medline:
11
2
2022
entrez:
28
11
2021
Statut:
ppublish
Résumé
Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.
Identifiants
pubmed: 34839148
pii: S0165-5728(21)00289-7
doi: 10.1016/j.jneuroim.2021.577762
pii:
doi:
Substances chimiques
CD40 Antigens
0
CD40 Ligand
147205-72-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577762Informations de copyright
Copyright © 2021. Published by Elsevier B.V.