Nonantibiotic Properties of Tetracyclines in Rosacea and Their Clinical Implications.
Tetracycline
anti-inflammatory
doxycycline
minocycline
nonantibiotic
pathophysiology
rosacea
Journal
The Journal of clinical and aesthetic dermatology
ISSN: 1941-2789
Titre abrégé: J Clin Aesthet Dermatol
Pays: United States
ID NLM: 101518173
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
entrez:
29
11
2021
pubmed:
30
11
2021
medline:
30
11
2021
Statut:
ppublish
Résumé
Rosacea is one of the most common inflammatory skin diseases in the United States, with a complex pathophysiology. One of the major components of the pathophysiology of rosacea is an abnormal immune detection and response to stimuli. Tetracyclines and their derivatives, including minocycline and doxycycline, have anti-inflammatory properties independent of their antibacterial activity that correlate with certain aspects of the pathophysiology, and these drugs are often used by dermatologists to treat rosacea. Biological actions of tetracyclines correlating with rosacea include anti-inflammatory and antioxidative activities, inhibitory effects on angiogenesis, and proteolysis. The objective of this review is to re-establish the current understanding of tetracyclines and their mechanism of action as they relate to the pathophysiology and treatment of rosacea for clinicians. This includes reviewing the inflammatory aspects of rosacea that correlate with the known nonantibiotic properties of tetracyclines and providing the most up-to-date clinical evidence supporting the use of tetracyclines to treat rosacea. Given the evolving and multifactorial nature of pathophysiology, this review offers clinicians a unified picture that includes research on the links between rosacea pathophysiology and clinical presentation, the nonantibiotic properties of tetracyclines that relate to pathophysiologic pathways in rosacea, and the potential for clinical application of tetracyclines in rosacea therapy.
Types de publication
Journal Article
Review
Langues
eng
Pagination
14-21Informations de copyright
Copyright © 2021. Matrix Medical Communications. All rights reserved.
Déclaration de conflit d'intérêts
DISCLOSURES: Dr. Del Rosso has served as a consultant (C), research investigator (RI), and/or speaker (S) for Vyne Therapeutics (C, RI, S), Almirall (C,RI, S), Bausch Health (C, RI, S), BiopharmX (C, S), Galderma (C, RI, S), JEM Health (C), Leo Pharma (C, RI, S), Mayne Pharma (C, S), Novan (C), and Sun Pharma (C,RI,S). Dr. Webster has served as a consultant for VYNE Therapeutics. Dr. Weiss is a speaker for AbbVie, Almirall, Ortho Dermatologics, Regeneron, Sanofi Genzyme; a consultant for Aclaris Therapeutics Inc. and LEO Pharma; an advisor for Dr. Reddy, VYNE Therapeutics Inc., Galderma Laboratories, LP, UCB, Valeant Pharmaceuticals International; and an investigator for AbbVie, Aclaris Therapeutics Inc., Celgene Corporation, Endo International Plc, VYNE Therapeutics Inc., Galderma, LEO Pharma, Moberg Pharma North America LLC, Novartis, Promius Pharma, LLC, and Valeant Pharmaceuticals International. Dr. Bhatia is an investigator and consultant for VYNE Therapeutics. Dr. Stein Gold is an advisor and investigator for VYNE Therapeutics Inc., Galderma, LEO Pharma, Novartis, and Valeant and is an investigator for Janssen, AbbVie, and Solgel. Dr. Kircik is an investigator and consultant for VYNE Therapeutics Inc.
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