Neurodevelopmental Outcomes of High-Risk Preterm Infants: A Prospective Study in Japan.

Journal

Neurology. Clinical practice
ISSN: 2163-0402
Titre abrégé: Neurol Clin Pract
Pays: United States
ID NLM: 101577149

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 31 01 2020
accepted: 07 07 2020
entrez: 29 11 2021
pubmed: 30 11 2021
medline: 30 11 2021
Statut: ppublish

Résumé

To determine the neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs, birth weight <1,500 g) after 9 years of follow-up. This study prospectively recruited 224 VLBWIs born from 2003 to 2009 in Kyushu University Hospital, Japan. Comorbidities of neurocognitive impairment, epilepsy, and autism spectrum disorder or attention-deficit hyperactivity disorder (ASD/ADHD) were assessed at age 3, 6, and 9 years. Neurodevelopmental profiles were obtained from 185 (83%), 150 (67%), and 119 (53%) participants at age 3, 6, and 9 years, respectively. At age 9 years, 25 (21%) VLBWIs showed intelligence quotient (IQ) <70, 11 (9%) developed epilepsy, and 14 (12%) had a diagnosis of ASD/ADHD. The prevalence of epilepsy was higher in children with an IQ <70 at age 9 years than in those with an IQ ≥70 (44% vs 0%). In contrast, ASD/ADHD appeared at similar frequencies in children with an IQ <70 (16%) and ≥70 (11%). Perinatal complications and severe brain lesions on MRI were considered common perinatal risks for developmental delay and epilepsy but not for ASD/ADHD. Male sex was identified as a unique risk factor for ASD/ADHD. These data suggest that VLBWIs showed a higher prevalence of developmental delay, epilepsy, and ASD/ADHD at age 9 years than the general population. Distinct mechanisms might be involved in the pathogenic process of ASD/ADHD from those of developmental delay and epilepsy.

Identifiants

DOI: 10.1212/CPJ.0000000000000920 PMID: 34840866 PMC: PMC8610512
pubmed: 34840866
doi: 10.1212/CPJ.0000000000000920
pii: NEURCLINPRACT2020050203
pmc: PMC8610512
doi:

Types de publication

Journal Article

Langues

eng

Pagination

398-405

Informations de copyright

© 2021 American Academy of Neurology.

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Auteurs

Michiko Torio (M)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Mariko Iwayama (M)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Toru Sawano (T)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Hirosuke Inoue (H)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Masayuki Ochiai (M)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Ryoji Taira (R)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Kousuke Yonemoto (K)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Yuko Ichimiya (Y)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Yuri Sonoda (Y)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Momoko Sasazuki (M)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Yoshito Ishizaki (Y)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Masafumi Sanefuji (M)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Kenichi Yamane (K)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Hiroshi Yamashita (H)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Hiroyuki Torisu (H)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Ryutaro Kira (R)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Toshiro Hara (T)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Shigenobu Kanba (S)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Yasunari Sakai (Y)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Shouichi Ohga (S)

Department of Pediatrics (MT, MI, TS, HI, MO, RT, K. Yonemoto, Y. Ichimiya, Y. Sonoda, M. Sasazuki, Y. Ishizaki, M. Sanefuji, Y. Sakai, SO), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Health and Welfare (M. Sasazuki), Seinan Jogakuin University, Kitakyushu; Department of Neuropsychiatry (K. Yamane, HY, SK), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Section of Pediatrics (HT), Department of Medicine, Fukuoka Dental College; and Fukuoka Children's Hospital (RK, TH), Japan.

Classifications MeSH