Non-invasive biomarkers of eosinophilic esophagitis.

Biomarkers / analysis Biopsy Eosinophilic Esophagitis / diagnosis Eosinophils Humans Leukocyte Count

Journal

Acta bio-medica : Atenei Parmensis
ISSN: 2531-6745
Titre abrégé: Acta Biomed
Pays: Italy
ID NLM: 101295064

Informations de publication

Date de publication:
29 11 2021
Historique:
received: 12 10 2021
accepted: 22 11 2021
entrez: 29 11 2021
pubmed: 30 11 2021
medline: 27 1 2022
Statut: epublish

Résumé

Eosinophilic esophagitis (EoE) is an emerging allergen-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic inflammation. EoE diagnosis requires 15 eosinophils per high power field (eos/HPF) in tissue biopsies endoscopically obtained. The need for several endoscopies to monitoring the disease and the absence of validated non-invasive biomarkers or tools are the main reasons for the significant burden on affected patients and the healthcare system. There is a critical need for non-invasive or minimally invasive biomarkers. In the last years, several efforts have been made to identify potential biomarkers for diagnosing and monitoring the disease that we summarized in this review. The future of EoE is exciting from both a diagnostic and therapeutic standpoint. Further research is required to confirm phenotypes and histological or serological biomarkers to provide a novel endotype classification based on different cytokine or genetic signatures relevant to precision medicine.

Identifiants

DOI: 10.23750/abm.v92iS7.12401 PMID: 34842593 PMC: PMC9431887
pubmed: 34842593
doi: 10.23750/abm.v92iS7.12401
pmc: PMC9431887
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2021530

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Auteurs

Martina Votto (M)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. martinavotto@gmail.com.

Maria De Filippo (M)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. maria_defilippo@hotmail.it.

Riccardo Castagnoli (R)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. riccardo.castagnoli@yahoo.it.

Francesco Delle Cave (F)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. dellecavefrancesco.fd@gmail.com.

Francesca Giffoni (F)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. francesca.giffoni01@universitadipavia.it.

Viola Santi (V)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. viola.santi92@gmail.com.

Marta Vergani (M)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. marta.vergani01@universitadipavia.it.

Carlo Caffarelli (C)

Pediatric Clinic, Department of Medicine and Surgery, Unversity of Parma, Parma, Italy. carlo.caffarelli@unipr.it.

Mara De Amici (M)

Immuno-Allergology Laboratory, Clinical Chemistry Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. m.deamici@smatteo.pv.it.

Gian Luigi Marseglia (GL)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. gl.marseglia@smatteo.pv.it.

Amelia Licari (A)

Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. a.licari@smatteo.pv.it.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Non-invasive biomarkers of eosinophilic esophagitis.
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Non-invasive biomarkers of eosinophilic esophagitis.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Oesophagite à éosinophiles › Non-invasive biomarkers of eosinophilic esophagitis.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes éosinophiles › Non-invasive biomarkers of eosinophilic esophagitis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-invasive biomarkers of eosinophilic esophagitis.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des leucocytes › Non-invasive biomarkers of eosinophilic esophagitis.