Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF.
assisted reproduction
embryos
gametes
telomeres
Journal
Journal of developmental biology
ISSN: 2221-3759
Titre abrégé: J Dev Biol
Pays: Switzerland
ID NLM: 101613409
Informations de publication
Date de publication:
13 Nov 2021
13 Nov 2021
Historique:
received:
18
10
2021
revised:
10
11
2021
accepted:
11
11
2021
entrez:
29
11
2021
pubmed:
30
11
2021
medline:
30
11
2021
Statut:
epublish
Résumé
Telomeres promote genome integrity by protecting chromosome ends from the activation of the DNA damage response and protecting chromosomes from the loss of coding sequences due to the end replication problem. Telomere length (TL) is progressively shortened as age progresses, thus resulting in cellular senescence. Therefore, TL is in strong adverse linear correlation with aging. Mounting evidence supports the notion that telomeres and male/female infertility are in a close relationship, posing the biology of telomeres as a hot topic in the era of human-assisted reproduction. Specifically, the length of sperm telomeres is gradually increasing as men get older, while the telomere length of the oocytes seems not to follow similar patterns with that of sperm. Nonetheless, the telomere length of the embryos during the cleavage stages seems to have a paternal origin, but the telomere length can be further extended by telomerase activity during the blastocyst stage. The latter has been proposed as a new molecular biomarker with strong predictive value regarding male infertility. As far as the role of telomeres in assisted reproduction, the data is limited but the length of telomeres in both gametes seems to be affected mainly by the cause of infertility rather than the assisted reproductive therapy (ART) procedure itself. The present review aims to shed more light into the role of telomeres in human embryological parameters, including gametes and embryos and also presents opinions regarding the association between telomeres and in vitro fertilization (IVF).
Identifiants
pubmed: 34842724
pii: jdb9040049
doi: 10.3390/jdb9040049
pmc: PMC8628962
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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