Significant correlations between focal photopic negative response and focal visual sensitivity and ganglion cell complex thickness in glaucomatous eyes.
Electroretinogram
Focal macular ERG
Glaucoma
PhNR
Photopic negative response
Journal
Japanese journal of ophthalmology
ISSN: 1613-2246
Titre abrégé: Jpn J Ophthalmol
Pays: Japan
ID NLM: 0044652
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
12
07
2021
accepted:
22
10
2021
pubmed:
30
11
2021
medline:
15
1
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
To determine whether there are significant correlations between the focal photopic negative response (PhNR), the focal visual sensitivity and the ganglion cell complex (GCC) thickness in glaucomatous eyes. Single-center observational study. Fifty-two eyes of 52 patients (71.4 ± 9.42 years) with clinically diagnosed open angle glaucoma were studied. Thirty-six age-matched normal subjects served as controls. The focal PhNR of the focal macular electroretinograms (fmERGs) were elicited by a 15° circular, a superior semicircular or an inferior semicircular stimulus centered on the fovea. The thickness of the GCC was measured in the corresponding retinal areas in the spectral-domain optical coherence tomographic images. The visual sensitivities (dB) were measured by microperimetry at the retinal area where the fmERGs were elicited and were converted to liner values (1/Lambert). The focal PhNR amplitudes were significantly correlated with the visual sensitivities of the full-circle (R = 0.532), the superior (R = 0.530) and inferior (R = 0.526) semicircular responses (P < 0.0001). The GCC thickness was correlated with the visual sensitivities in the same areas with stronger correlations (R = 0.700, 0.759 and 0.650, respectively; P < 0.0001). The focal PhNR amplitudes were proportionally reduced with the thinning of the GCC thickness (R = 0.494, 0.518 and 0.511, respectively; P < 0.0001). The significant correlations between the focal PhNR amplitudes, the focal visual sensitivities and the GCC thickness indicate that these may be good biomarkers to track the changes in the physiology and anatomy of the macular area in glaucomatous eyes.
Identifiants
pubmed: 34843022
doi: 10.1007/s10384-021-00886-w
pii: 10.1007/s10384-021-00886-w
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-51Subventions
Organisme : japan society for the promotion of science
ID : 18K09420
Informations de copyright
© 2021. Japanese Ophthalmological Society.
Références
Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith EL 3rd. The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci. 1999;40:1124–36.
pubmed: 10235545
Viswanathan S, Frishman LJ, Robson JG, Walters JW. The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci. 2001;42:514–22.
pubmed: 11157891
Gotoh Y, Machida S, Tazawa Y. Selective loss of the photopic negative response in patients with optic nerve atrophy. Arch Ophthalmol. 2004;122:341–6.
pubmed: 15006846
Machida S, Gotoh Y, Tanaka M, Tazawa Y. Predominant loss of the photopic negative response in central retinal artery occlusion. Am J Ophthalmol. 2004;137:938–40.
pubmed: 15126164
Rangaswamy NV, Frishman LJ, Dorotheo EU, Schiffman JS, Bahrani HM, Tang RA. Photopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina. Invest Ophthalmol Vis Sci. 2004;45:3827–37.
pubmed: 15452095
Miyata K, Nakamura M, Kondo M, Lin J, Ueno S, Miyake Y, et al. Reduction of oscillatory potentials and photopic negative response in patients with autosomal dominant optic atrophy with OPA1 mutations. Invest Ophthalmol Vis Sci. 2007;48:820–4.
pubmed: 17251483
Ueno S, Kondo M, Piao CH, Ikenoya K, Miyake Y, Terasaki H. Selective amplitude reduction of the PhNR after macular hole surgery: ganglion cell damage related to ICG-assisted ILM peeling and gas tamponade. Invest Ophthalmol Vis Sci. 2006;47:3545–9.
pubmed: 16877427
Chen H, Wu D, Huang S, Yan H. The photopic negative response of the flash electroretinogram in retinal vein occlusion. Doc Ophthalmol. 2006;113:53–9.
pubmed: 16944088
Kizawa J, Machida S, Kobayashi T, Gotoh Y, Kurosaka D. Changes of oscillatory potentials and photopic negative response in patients with early diabetic retinopathy. Jpn J Ophthalmol. 2006;50:367–73.
pubmed: 16897223
Moon CH, Hwang SC, Ohn YH, Park TK. The time course of visual field recovery and changes of retinal ganglion cells after optic chiasmal decompression. Invest Ophthalmol Vis Sci. 2011;52:7966–73.
pubmed: 21896856
Machida S, Gotoh Y, Toba Y, Ohtaki A, Kaneko M, Kurosaka D. Correlation between photopic negative response and retinal nerve fiber layer thickness and optic disc topography in glaucomatous eyes. Invest Ophthalmol Vis Sci. 2008;49:2201–7.
pubmed: 18436853
Tamada K, Machida S, Yokoyama D, Kurosaka D. Photopic negative response of full-field and focal macular electroretinograms in patients with optic nerve atrophy. Jpn J Ophthalmol. 2009;53:608–14.
pubmed: 20020240
Moon CH, Hwang SC, Kim BT, Ohn YH, Park TK. Visual prognostic value of optical coherence tomography and photopic negative response in chiasmal compression. Invest Ophthalmol Vis Sci. 2011;52:8527–33.
pubmed: 21960556
Wang J, Cheng H, Hu YS, Tang RA, Frishman LJ. The photopic negative response of the flash electroretinogram in multiple sclerosis. Invest Ophthalmol Vis Sci. 2012;53:1315–23.
pubmed: 22273726
pmcid: 3339907
Machida S. Clinical applications of the photopic negative response to optic nerve and retinal diseases. J Ophthalmol. 2012;2012: 397178. https://doi.org/10.1155/2012/397178 .
doi: 10.1155/2012/397178
pubmed: 23133741
pmcid: 3486014
Miyake Y, Yanagida K, Kondo K, Ota I. Subjective scotometry and recording of local electroretinogram and visual evoked response. System with television monitor of the fundus. Jpn J Ophthalmol. 1981;25:439–48.
Miyake Y. Studies of local macular ERG. Nippon Ganka Gakkai Zassh. 1988;92:1419–49 (in Japanese).
Machida S, Toba Y, Ohtaki A, Gotoh Y, Kaneko M, Kurosaka D. Photopic negative response of focal electroretinograms in glaucomatous eyes. Invest Ophthalmol Vis Sci. 2008;49:5636–44.
pubmed: 18641287
Kurimoto Y, Kondo M, Ueno S, Sakai T, Machida S, Terasaki H. Asymmetry of focal macular photopic negative responses (PhNRs) in monkeys. Exp Eye Res. 2009;88:92–8.
pubmed: 18996372
Nakamura H, Hangai M, Mori S, Hirose F, Yoshimura N. Hemispherical focal macular photopic negative response and macular inner retinal thickness in open-angle glaucoma. Am J Ophthalmol. 2011;151:494–506.
pubmed: 21236410
Tamada K, Machida S, Oikawa T, Miyamoto H, Nishimura T, Kurosaka D. Correlation between photopic negative response of focal electroretinograms and local loss of retinal neurons in glaucoma. Curr Eye Res. 2010;35:155–64.
pubmed: 20136426
Machida S, Kaneko M, Kurosaka D. Regional variations in correlation between photopic negative response of focal electroretinograms and ganglion cell complex in glaucoma. Curr Eye Res. 2015;40:439–49.
pubmed: 24871085
Kaneko M, Machida S, Hoshi Y, Kurosaka D. Alterations of photopic negative response of multifocal electroretinogram in patients with glaucoma. Curr Eye Res. 2015;40:77–86.
pubmed: 24832792
Quigley HA, Green WR. The histology of human glaucoma cupping and optic nerve damage: clinicopathologic correlation in 21 eyes. Ophthalmology. 1979;86:1803–30.
pubmed: 553256
Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol. 1989;107:453–64.
pubmed: 2712129
Colotto A, Falsini B, Salgarello T, Iarossi G, Galan ME, Scullica L. Photopic negative response of the human ERG: losses associated with glaucomatous damage. Invest Ophthalmol Vis Sci. 2000;41:2205–11.
pubmed: 10892864
Machida S, Tamada K, Oikawa T, Yokoyama D, Kaneko M, Kurosaka D. Sensitivity and specificity of photopic negative response of focal electoretinogram to detect glaucomatous eyes. Br J Ophthalmol. 2010;94:202–8.
pubmed: 19692386
Machida S, Tamada K, Oikawa T, Gotoh Y, Nishimura T, Kaneko M, et al. Comparison of photopic negative response of full-field and focal electroretinograms in detecting glaucomatous eyes. J Ophthalmol. 2011;2011:564131.
pubmed: 20936059
Rao HL, Januwada M, Hussain RS, Pillutla LN, Begum VU, Chaitanya A, et al. Comparing the structure-function relationship at the macula with standard automated perimetry and microperimetry. Invest Ophthalmol Vis Sci. 2015;56:8063–8.
pubmed: 26720457
Harwerth RS, Carter-Dawson L, Shen F, Smith EL 3rd, Crawford ML. Ganglion cell losses underlying visual field defects from experimental glaucoma. Invest Ophthalmol Vis Sci. 1999;40:2242–50.
pubmed: 10476789
Harwerth RS, Carter-Dawson L, Smith EL 3rd, Barnes G, Holt WF, Crawford ML. Neural losses correlated with visual losses in clinical perimetry. Invest Ophthalmol Vis Sci. 2004;45:3152–60.
pubmed: 15326134
Harwerth RS, Quigley HA. Visual field defects and retinal ganglion cell losses in patients with glaucoma. Arch Ophthalmol. 2006;124:853–9.
pubmed: 16769839
pmcid: 2265071
Harwerth RS, Vilupuru AS, Rangaswamy NV, Smith EL 3rd. The relationship between nerve fiber layer and perimetry measurements. Invest Ophthalmol Vis Sci. 2007;48:763–73.
pubmed: 17251476
Hood DC, Greenstein VC, Odel JG, Zhang X, Ritch R, Liebmann JM, et al. Visual field defects and multifocal visual evoked potentials: evidence of a linear relationship. Arch Ophthalmol. 2002;120:1672–81.
pubmed: 12470141
Hood DC, Anderson SC, Wall M, Kardon RH. Structure versus function in glaucoma: an application of a linear model. Invest Ophthalmol Vis Sci. 2007;48:3662–8.
pubmed: 17652736
Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res. 2007;26:688–710.
pubmed: 17889587
pmcid: 2110881
Scuderi G, Fragiotta S, Scuderi L, Iodice CM, Perdicchi A. Ganglion cell complex analysis in glaucoma patients: what can it tell us? Eye Brain. 2020;12:33–44.
pubmed: 32099501
pmcid: 6999543
Frishman LJ. Origin of the electroretinogram. In: Heckenlively JR, Arden GB, editors. Principles and practice of clinical electrophysiology of vision. 2nd ed. Cambridge: Massachusetts Institute of Technology; 2006. p. 139–83.
Viswanathan S, Frishman LJ. Evidence that negative potentials in the photopic electroretinograms of cats and primates depend upon spiking activity of retinal ganglion cell axons. Soc Neurosci Abstr. 1997;23:1024.
Tanihara H, Hangai M, Sawaguchi S, Abe H, Kageyama M, Nakazawa F, et al. Up-regulation of glial fibrillary acidic protein in the retina of primate eyes with experimental glaucoma. Arch Ophthalmol. 1997;115:752–6.
pubmed: 9194727
Machida S, Kondo M, Jamison JA, Khan NW, Kononen LT, Sugawara T, et al. P23H rhodopsin transgenic rat: correlation of retinal function with histopathology. Invest Ophthalmol Vis Sci. 2000;41:3200–9.
pubmed: 10967084
Hood DC, Benimoff NI, Greenstein VC. The response range of the blue-cone pathways: a source of vulnerability to disease. Invest Ophthalmol Vis Sci. 1984;25:864–7.
pubmed: 6735651
Raza AS, Cho J, de Moraes CG, Wang M, Zhang X, Kardon RH, et al. Retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma. Arch Ophthalmol. 2011;129:1529–36.
pubmed: 22159673
pmcid: 4331118
Hood DC, Raza AS, de Moraes CG, Odel JG, Greenstein VC, Liebmann JM, et al. Initial arcuate defects within the central 10 degrees in glaucoma. Invest Ophthalmol Vis Sci. 2011;52:940–6.
pubmed: 20881293
pmcid: 3053114
Turpin A, Chen S, Sepulveda JA, McKendrick AM. Customizing structure-function displacements in the macula for individual differences. Invest Ophthalmol Vis Sci. 2015;56:5984–9.
pubmed: 26393464
Frishman L, Sustar M, Kremers J, McAnany JJ, Sarossy M, Tzekov R, et al. ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram. Doc Ophthalmol. 2018;136:207–11.
pubmed: 29855761
pmcid: 6061118