Salivary parameters and their correlation with neutrophil counts in children with acute lymphoblastic leukemia.
Absolute neutrophil count
Chemotherapy
Leukemia
Salivary parameters
Journal
European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
ISSN: 1996-9805
Titre abrégé: Eur Arch Paediatr Dent
Pays: England
ID NLM: 101277157
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
24
03
2021
accepted:
23
10
2021
pubmed:
30
11
2021
medline:
13
4
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
Chemotherapy for Acute Lymphoblastic Leukemia (ALL) is known to render children immuno-deficient. A concomitant suppression of local defence mechanisms, such as saliva may further aggravate the adverse consequences of chemotherapy. The present study was conducted to evaluate alterations in salivary flow rate, pH and buffering capacity and to correlate these parameters with Absolute Neutrophil Counts (ANC). A cohort of 43 patients, aged 3-12 years were evaluated for the aforementioned parameters at baseline, post-induction and post-consolidation phases. Salivary collection was done and ANC was measured from routine haematological reports. A decrease in the salivary parameters was observed at the end of Induction phase as compared to baseline, with a statistically significant decrease in unstimulated salivary flow rates (p < 0.01). Statistically significant positive correlations were found between ANC and salivary flow rate (p = 0.005), pH (p < 0.00) and buffering capacity (p < 0.00). On testing the significance of these correlations, all the values for these parameters were found to be statistically significant. Salivary parameters showed derangements over the phases of chemotherapy, with maximum decrease at the end of induction phase. The positive correlations of salivary parameters with ANC of the subjects may be considered indicative of a concomitant immunological compromise in these children.
Sections du résumé
BACKGROUND
BACKGROUND
Chemotherapy for Acute Lymphoblastic Leukemia (ALL) is known to render children immuno-deficient. A concomitant suppression of local defence mechanisms, such as saliva may further aggravate the adverse consequences of chemotherapy. The present study was conducted to evaluate alterations in salivary flow rate, pH and buffering capacity and to correlate these parameters with Absolute Neutrophil Counts (ANC).
METHODS
METHODS
A cohort of 43 patients, aged 3-12 years were evaluated for the aforementioned parameters at baseline, post-induction and post-consolidation phases. Salivary collection was done and ANC was measured from routine haematological reports.
RESULTS
RESULTS
A decrease in the salivary parameters was observed at the end of Induction phase as compared to baseline, with a statistically significant decrease in unstimulated salivary flow rates (p < 0.01). Statistically significant positive correlations were found between ANC and salivary flow rate (p = 0.005), pH (p < 0.00) and buffering capacity (p < 0.00). On testing the significance of these correlations, all the values for these parameters were found to be statistically significant.
CONCLUSION
CONCLUSIONS
Salivary parameters showed derangements over the phases of chemotherapy, with maximum decrease at the end of induction phase. The positive correlations of salivary parameters with ANC of the subjects may be considered indicative of a concomitant immunological compromise in these children.
Identifiants
pubmed: 34843095
doi: 10.1007/s40368-021-00679-2
pii: 10.1007/s40368-021-00679-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
281-287Informations de copyright
© 2021. European Academy of Paediatric Dentistry.
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