First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Cell Line, Tumor
Cell Proliferation
/ drug effects
Crystallization
Dioxygenases
/ antagonists & inhibitors
Enzyme Inhibitors
/ metabolism
Histone Demethylases
/ antagonists & inhibitors
Humans
Models, Molecular
Nuclear Proteins
/ antagonists & inhibitors
Protein Conformation
Ribosomes
/ enzymology
Substrate Specificity
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
09 12 2021
09 12 2021
Historique:
pubmed:
30
11
2021
medline:
22
1
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
MINA53 is a JmjC domain 2-oxoglutarate-dependent oxygenase that catalyzes ribosomal hydroxylation and is a target of the oncogenic transcription factor
Identifiants
pubmed: 34843649
doi: 10.1021/acs.jmedchem.1c00605
pmc: PMC8667043
doi:
Substances chimiques
Enzyme Inhibitors
0
Nuclear Proteins
0
Dioxygenases
EC 1.13.11.-
Histone Demethylases
EC 1.14.11.-
RIOX2 protein, human
EC 1.14.11.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17031-17050Subventions
Organisme : Cancer Research UK
ID : C8717/A18245
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106244/Z/14/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A23900
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N021053/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L009846/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C33483/A25674
Pays : United Kingdom
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