A metabolomics approach identified toxins associated with uremic symptoms in advanced chronic kidney disease.
chronic kidney disease
metabolomics
uremia
uremic symptoms
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
08
03
2021
revised:
27
09
2021
accepted:
01
10
2021
pubmed:
30
11
2021
medline:
12
3
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
Uremic symptoms are common in patients with advanced chronic kidney disease, but the toxins that cause these symptoms are unknown. To evaluate this, we performed a cross-sectional study of the 12 month post-randomization follow-up visit of Modification of Diet in Renal Disease (MDRD) participants reporting uremic symptoms who also had available stored serum. We quantified 1,163 metabolites by liquid chromatography-tandem mass spectrometry. For each uremic symptom, we calculated a score as the severity multiplied by the number of days the symptom was experienced. We analyzed the associations of the individual symptom scores with metabolites using linear models with empirical Bayesian inference, adjusted for multiple comparisons. Among 695 participants, the mean measured glomerular filtration rate (mGFR) was 28 mL/min/1.73 m
Identifiants
pubmed: 34843755
pii: S0085-2538(21)01076-0
doi: 10.1016/j.kint.2021.10.035
pmc: PMC8792216
mid: NIHMS1766195
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-378Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL132372
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR017399
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085689
Pays : United States
Informations de copyright
Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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